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公开(公告)号：KR20210030540A
公开(公告)日：2021-03-18
申请号：KR1020190111584A
申请日：2019-09-09
Applicant: 동국대학교 산학협력단 , 서울대학교산학협력단
IPC: C07D307/60 , A61K31/341 , A61P3/00
CPC classification number: C07D307/60 , A61K31/341 , A61P3/00
Abstract: 본 발명은 신규한 부타놀리드 이량체 화합물 및 이를 유효성분으로 함유하는 아디포넥틴 분비 촉진용 조성물에 관한 것으로, 보다 상세하게는 약한 PPARγ 결합 활성을 나타내는 마리올라이드 유도체 두 분자를 신규한 형태로 연결한 부타놀리드 이량체 화합물은 hBM-MSCs 지방분화 모델에서 PPARγ 완전 효능제로 작용하여 우수한 PPARγ 결합 활성을 나타내었으며, 이를 통하여 아디포넥틴 분비 촉진효과를 나타내는 것으로 확인됨에 따라, 상기 부타놀리드 이량체 화합물은 PPARγ 활성화제, 아디포넥틴 분비 촉진제 및 아디포넥틴 분비 조절 장애에 의해 유발되는 대사성 질환 치료용 조성물로 제공될 수 있다.
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公开(公告)号：KR1020140002516A
公开(公告)日：2014-01-08
申请号：KR1020130073746
申请日：2013-06-26
Applicant: 동국대학교 산학협력단
CPC classification number: C12Q1/6881 , C12Q2600/142 , C12Q2600/158 , G01N33/6893 , G01N2333/46 , G01N2800/40
Abstract: The invention provides a composition for a diagnosis of melanocyte cytotoxicity which includes materials for measuring mRNA or protein level of S100B gene. The expression of S100B according to the invention is increased by stimulation to the skin and especially the expression is significantly increased only in melanocytes. Therefore, the invention has an excellent effect to diagnose stimulation by skin specifically to melanocytes so that the invention is useful for the diagnosis of melanocyte cytotoxicity.
Abstract translation: 本发明提供了用于诊断黑素细胞细胞毒性的组合物，其包括用于测量S100B基因的mRNA或蛋白质水平的材料。 根据本发明的S100B的表达通过刺激皮肤而增加，特别是仅在黑素细胞中表达显着增加。 因此，本发明对于诊断特定于黑素细胞的皮肤刺激具有极好的效果，因此本发明可用于诊断黑素细胞的细胞毒性。
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公开(公告)号：KR1020140123437A
公开(公告)日：2014-10-22
申请号：KR1020140043178
申请日：2014-04-10
Applicant: 동국대학교 산학협력단
CPC classification number: C12Q1/6811 , C12N15/11 , G01N33/53
Abstract: 본 발명은 피부 자극 물질 스크리 닝용 조성물 및 이를 이용한 피부 자극 물질의 스크리닝 방법에 관한 것이다. 본 발명의 PI3, CEBPA, SERP INB3, HOPX, SPRR1A, NOD2, LCE3D, CNFN, TMTC1, KRTDAP, ANKRD35, SBSN, BPIL2, RDH12, FLG, H19, FLG2, LOR, IVL, NLRX1, ALDH1A3, DSC2, RHCG, SCEL, IL20, S100A8, S100A9, S100A12, BNIPL, SPRR3, TMEM79, FAM84A, GRHL1, SGPP2, AADACL2, TPRG1, PPP2R2C, SPINK5, ATP10B, GPR110, IL20RA, DEFB1, SLC28A3, AIF1L, CLIC3, NEBL, CARD18, PLBD1, GLTP, TGM1, ZNF750, DSC1, SERPINB13, EMR2, KLK10, COX7A1, SULT2B1 및 KLK7 유전자는 피부자극 물질로 일반적인 하이드로퀴논, 레티노산 또는 SLS를 처리하는 경우, 발현양이 증가하거나 감소함으로써, 상기 유전자를 이용하여 유해한 피부 자극 물질을 스크리닝할 수 있다. 따라서, 화장품 원료 물질의 동물실험이 금지되어 이를 대체할 수 있는 피부 자극 물질을 스크링하는 방법으로 유용하게 사용할 수 있다.
Abstract translation: 本发明涉及一种用于筛选皮肤刺激物的组合物和使用该组合物筛选皮肤刺激物的方法。 当PI3，CEBPA，SERP INB3，HOPX，SPRR1A，NOD2，LCE3D，CNFN，TMTC1，KRTDAP，ANKRD35，SBSN，BPIL2，RDH12，FLG，H19，FLG2，LOR，IVL，NLRX1，ALDH1A3，DSC2，RHCG，SCEL， IL20，S100A8，S100A9，S100A12，BNIPL，SPRR3，TMEM79，FAM84A，GRHL1，SGPP2，AADACL2，TPRG1，PPP2R2C，SPINK5，ATP10B，GPR110，IL20RA，DEFB1，SLC28A3，AIF1L，CLIC3，NEBL，CARD18，PLBD1，GLTP， 本发明的TGM1，ZNF750，DSC1，SERPINB13，EMR2，KLK10，COX7A1，SULT2B1和KLK7基因均被普通对苯二酚，视黄酸或SLS作为皮肤刺激剂加工，表达量增加或降低; 从而筛选使用该基因的有害皮肤刺激物。 因此，本发明可以用作筛选皮肤刺激剂而不是化妆品原料的禁止动物实验的方法。
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公开(公告)号：KR101511021B1
公开(公告)日：2015-04-10
申请号：KR1020130073746
申请日：2013-06-26
Applicant: 동국대학교 산학협력단
Abstract: 본발명은 S100B 유전자의 mRNA 또는단백질수준을측정하는제제를포함하는멜라닌세포의세포독성진단용조성물을제공한다. 본발명에따른 S100B는피부자극에의하여발현이증가되며, 특히멜라닌세포에서만유의적으로발현이증가하여, 멜라닌세포에특이적으로피부자극을진단할수 있는효과가우수하므로, 멜라닌세포의세포독성진단에유용하게이용될수 있다.
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Patent Agency Ranking
公开(公告)号：KR1020120112189A
公开(公告)日：2012-10-11
申请号：KR1020120032475
申请日：2012-03-29
Applicant: 동국대학교 산학협력단
CPC classification number: A61K8/64 , A61K2800/782 , A61Q19/00
Abstract: PURPOSE: A cosmetic composition containing PDZK1 expression or activation inhibitor is provided to suppress calcium ion inflow into keratinocytes and to prevent or relieve melasma. CONSTITUTION: A cosmetic composition for preventing or treating melasma contain PDZK1(PDZ domain containing 1) expression or activation inhibitors as an active ingredient. The PDZK1 expression inhibitor is an antisense nucleotide, siRNA, or shRNA. The PDZK1 activation inhibitor is compounds which complementarily bind to the protein, peptides, peptide mimetics, aptamers, or antibodies.
Abstract translation: 目的：提供含有PDZK1表达或活化抑制剂的化妆品组合物，以抑制钙离子流入角质形成细胞并预防或缓解黑斑病。 构成：用于预防或治疗黑斑病的化妆品组合物含有PDZK1（含有1个PDZ结构域）表达或活化抑制剂作为活性成分。 PDZK1表达抑制剂是反义核苷酸，siRNA或shRNA。 PDZK1激活抑制剂是与蛋白质，肽，肽模拟物，适配体或抗体互补结合的化合物。
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公开(公告)号：KR102083438B1
公开(公告)日：2020-03-03
申请号：KR1020110114689
申请日：2011-11-04
Applicant: (주)아모레퍼시픽 , 동국대학교 산학협력단
IPC: C12N15/63 , C12N15/861 , C12Q1/68 , G01N33/53
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公开(公告)号：KR101618950B1
公开(公告)日：2016-05-09
申请号：KR1020140043178
申请日：2014-04-10
Applicant: 동국대학교 산학협력단
Abstract: 본발명은피부자극물질스크리닝용조성물및 이를이용한피부자극물질의스크리닝방법에관한것이다. 본발명의 PI3, CEBPA, SERP INB3, HOPX, SPRR1A, NOD2, LCE3D, CNFN, TMTC1, KRTDAP, ANKRD35, SBSN, BPIL2, RDH12, FLG, H19, FLG2, LOR, IVL, NLRX1, ALDH1A3, DSC2, RHCG, SCEL, IL20, S100A8, S100A9, S100A12, BNIPL, SPRR3, TMEM79, FAM84A, GRHL1, SGPP2, AADACL2, TPRG1, PPP2R2C, SPINK5, ATP10B, GPR110, IL20RA, DEFB1, SLC28A3, AIF1L, CLIC3, NEBL, CARD18, PLBD1, GLTP, TGM1, ZNF750, DSC1, SERPINB13, EMR2, KLK10, COX7A1, SULT2B1 및 KLK7 유전자는피부자극물질로일반적인하이드로퀴논, 레티노산또는 SLS를처리하는경우, 발현양이증가하거나감소함으로써, 상기유전자를이용하여유해한피부자극물질을스크리닝할수 있다. 따라서, 화장품원료물질의동물실험이금지되어이를대체할수 있는피부자극물질을스크링하는방법으로유용하게사용할수 있다.
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公开(公告)号：KR1020140002142A
公开(公告)日：2014-01-08
申请号：KR1020120069739
申请日：2012-06-28
Applicant: 동국대학교 산학협력단
CPC classification number: G01N33/6803 , C12Q1/6883 , C12Q2600/158 , G01N33/5302 , G01N33/5308 , G01N33/6881 , G01N2800/20
Abstract: The invention provides a diagnostic composition of melanocyte-specific retinoic acid stimulation, which includes materials for measuring the level of mRNA or protein of PDZRN3 gene. The expression of PDZRN3 according to the present invention is increased by retinoic acid stimulation and the increase of expression by retinoic acid stimulation does not appear in an independent culture of keratinocytes, but the expression is significantly increased only in melanocytes. Therefore, the invention has an excellent effect to diagnose melanocyte-specific retinoic acid stimulation and is useful for diagnosis of the same.
Abstract translation: 本发明提供黑素细胞特异性视黄酸刺激的诊断组合物，其包括用于测量PDZRN3基因mRNA或蛋白质水平的材料。 根据本发明的PDZRN3的表达通过视黄酸刺激而增加，并且在角质形成细胞的独立培养中不出现视黄酸刺激的表达增加，但是仅在黑素细胞中表达显着增加。 因此，本发明对于诊断黑素细胞特异性视黄酸刺激具有优异的效果，对于诊断为其有用。
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公开(公告)号：KR1020130049589A
公开(公告)日：2013-05-14
申请号：KR1020110114689
申请日：2011-11-04
Applicant: (주)아모레퍼시픽 , 동국대학교 산학협력단
IPC: C12N15/63 , C12N15/861 , C12Q1/68 , G01N33/53
CPC classification number: C12N15/635 , C12N15/861 , C12Q1/6883 , C12Q2600/148 , C12Q2600/158 , G01N33/5023 , G01N33/5302 , G01N33/6881
Abstract: PURPOSE: A method for screening a material which enhances a skin barrier function is provided to effectively screening the material, and to diagnose diseases related to the skin barrier function. CONSTITUTION: A method for screening a material which enhances a skin barrier function comprises a step of determining a material which suppresses the expression of PDZK1 genes as the material which enhances the skin barrier function by screening the material which suppresses the expression of the PDZK1 genes. The method comprises a step of treating a nucleic acid molecule of PDZK1 with a candidate material, and a step of detecting expression change. The treatment with the candidate material comprises a step of treating a skin cell which is transformed with a vector containing the nucleic acid molecule with the candidate material. The skin cell is keratinocyte. The vector is adenovirus. A composition for enhancing the skin barrier function contains the material which suppresses the expression of the PDZK1 genes as an active ingredient. [Reference numerals] (AA) Comparative example 1; (BB) Example 1
Abstract translation: 目的：提供一种筛选增强皮肤屏障功能的材料的方法，以有效筛选材料，并诊断与皮肤屏障功能相关的疾病。 构成：用于筛选增强皮肤屏障功能的材料的方法包括测定通过筛选抑制PDZK1基因表达的材料来抑制PDZK1基因表达的材料作为增强皮肤屏障功能的材料的步骤。 该方法包括用候选物质处理PDZK1的核酸分子的步骤和检测表达变化的步骤。 用候选材料的处理包括用候选材料处理用含有核酸分子的载体转化的皮肤细胞的步骤。 皮肤细胞是角质形成细胞。 载体是腺病毒。 用于增强皮肤屏障功能的组合物含有抑制作为活性成分的PDZK1基因表达的材料。 （附图标记）（AA）比较例1; （BB）实施例1
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