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公开(公告)号：WO2023075062A1
公开(公告)日：2023-05-04
申请号：PCT/KR2022/008067
申请日：2022-06-08
Applicant: 동국대학교 산학협력단
IPC: A61K31/495 , A61P35/00 , A61P35/04 , A23L33/10
Abstract: 본 발명의 화학식 1로 표기되는 화합물을 포함하는 흑색종 예방 또는 치료용 조성물에 대한 것으로, 본 발명은 흑색종 세포주에서 독성을 유발하며, 흑색종의 크기를 감소시키고, 흑색종 내 CD8양성 세포독성 T 세포의 침윤을 증가시키며, 흑색종의 전이를 억제시키는 효과를 확인하였으며 이를 이용하여 흑색종 또는 흑색종전이의 예방, 개선 및 치료에 활용할 수 있다.
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公开(公告)号：KR1020140123437A
公开(公告)日：2014-10-22
申请号：KR1020140043178
申请日：2014-04-10
Applicant: 동국대학교 산학협력단
CPC classification number: C12Q1/6811 , C12N15/11 , G01N33/53
Abstract: 본 발명은 피부 자극 물질 스크리 닝용 조성물 및 이를 이용한 피부 자극 물질의 스크리닝 방법에 관한 것이다. 본 발명의 PI3, CEBPA, SERP INB3, HOPX, SPRR1A, NOD2, LCE3D, CNFN, TMTC1, KRTDAP, ANKRD35, SBSN, BPIL2, RDH12, FLG, H19, FLG2, LOR, IVL, NLRX1, ALDH1A3, DSC2, RHCG, SCEL, IL20, S100A8, S100A9, S100A12, BNIPL, SPRR3, TMEM79, FAM84A, GRHL1, SGPP2, AADACL2, TPRG1, PPP2R2C, SPINK5, ATP10B, GPR110, IL20RA, DEFB1, SLC28A3, AIF1L, CLIC3, NEBL, CARD18, PLBD1, GLTP, TGM1, ZNF750, DSC1, SERPINB13, EMR2, KLK10, COX7A1, SULT2B1 및 KLK7 유전자는 피부자극 물질로 일반적인 하이드로퀴논, 레티노산 또는 SLS를 처리하는 경우, 발현양이 증가하거나 감소함으로써, 상기 유전자를 이용하여 유해한 피부 자극 물질을 스크리닝할 수 있다. 따라서, 화장품 원료 물질의 동물실험이 금지되어 이를 대체할 수 있는 피부 자극 물질을 스크링하는 방법으로 유용하게 사용할 수 있다.
Abstract translation: 本发明涉及一种用于筛选皮肤刺激物的组合物和使用该组合物筛选皮肤刺激物的方法。 当PI3，CEBPA，SERP INB3，HOPX，SPRR1A，NOD2，LCE3D，CNFN，TMTC1，KRTDAP，ANKRD35，SBSN，BPIL2，RDH12，FLG，H19，FLG2，LOR，IVL，NLRX1，ALDH1A3，DSC2，RHCG，SCEL， IL20，S100A8，S100A9，S100A12，BNIPL，SPRR3，TMEM79，FAM84A，GRHL1，SGPP2，AADACL2，TPRG1，PPP2R2C，SPINK5，ATP10B，GPR110，IL20RA，DEFB1，SLC28A3，AIF1L，CLIC3，NEBL，CARD18，PLBD1，GLTP， 本发明的TGM1，ZNF750，DSC1，SERPINB13，EMR2，KLK10，COX7A1，SULT2B1和KLK7基因均被普通对苯二酚，视黄酸或SLS作为皮肤刺激剂加工，表达量增加或降低; 从而筛选使用该基因的有害皮肤刺激物。 因此，本发明可以用作筛选皮肤刺激剂而不是化妆品原料的禁止动物实验的方法。
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公开(公告)号：KR101511021B1
公开(公告)日：2015-04-10
申请号：KR1020130073746
申请日：2013-06-26
Applicant: 동국대학교 산학협력단
Abstract: 본발명은 S100B 유전자의 mRNA 또는단백질수준을측정하는제제를포함하는멜라닌세포의세포독성진단용조성물을제공한다. 본발명에따른 S100B는피부자극에의하여발현이증가되며, 특히멜라닌세포에서만유의적으로발현이증가하여, 멜라닌세포에특이적으로피부자극을진단할수 있는효과가우수하므로, 멜라닌세포의세포독성진단에유용하게이용될수 있다.
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公开(公告)号：KR1020140002516A
公开(公告)日：2014-01-08
申请号：KR1020130073746
申请日：2013-06-26
Applicant: 동국대학교 산학협력단
CPC classification number: C12Q1/6881 , C12Q2600/142 , C12Q2600/158 , G01N33/6893 , G01N2333/46 , G01N2800/40
Abstract: The invention provides a composition for a diagnosis of melanocyte cytotoxicity which includes materials for measuring mRNA or protein level of S100B gene. The expression of S100B according to the invention is increased by stimulation to the skin and especially the expression is significantly increased only in melanocytes. Therefore, the invention has an excellent effect to diagnose stimulation by skin specifically to melanocytes so that the invention is useful for the diagnosis of melanocyte cytotoxicity.
Abstract translation: 本发明提供了用于诊断黑素细胞细胞毒性的组合物，其包括用于测量S100B基因的mRNA或蛋白质水平的材料。 根据本发明的S100B的表达通过刺激皮肤而增加，特别是仅在黑素细胞中表达显着增加。 因此，本发明对于诊断特定于黑素细胞的皮肤刺激具有极好的效果，因此本发明可用于诊断黑素细胞的细胞毒性。
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Patent Agency Ranking
公开(公告)号：KR1020120091957A
公开(公告)日：2012-08-20
申请号：KR1020110012090
申请日：2011-02-10
Applicant: 동국대학교 산학협력단
Abstract: PURPOSE: An immunity control method using a light emitting diode is provided to emit light from the light emitting diode having the specific wavelength to objects. CONSTITUTION: An immunity control method using a light emitting diode includes a step of emitting light from the light emitting diode having the wavelength selected from the range from 600 to 1,000nm to objects. The selected wavelength for the emitted light is 850nm, and the light is emitted in the quantity of 5-200J per square centimeter.
Abstract translation: 目的：提供使用发光二极管的免疫控制方法，从具有特定波长的发光二极管发光到物体。 构成：使用发光二极管的免疫控制方法包括从具有选自600〜1000nm范围的波长的发光二极管发光的物体的步骤。 发射光的选定波长为850nm，发光量为每平方厘米5-200J。
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公开(公告)号：KR100951446B1
公开(公告)日：2010-04-07
申请号：KR1020090006366
申请日：2009-01-23
Applicant: 동국대학교 산학협력단
CPC classification number: C12N15/11 , C12Q1/6827 , C12Q2600/156 , C12Q2600/158
Abstract: PURPOSE: A TSLP(Thymic stromal lymphopoietin) for diagnosing vitiligo is provided to simply and quickly diagnose vitiligo and enhance treatment effect of vitiligo. CONSTITUTION: A marker for diagnosing sensitivity to vitiligo is a polynucleotide comprising sequence number 1](rs3806933). The site of SNP(single nucleotide polymorphism) of the polynucleotide is 27th base, C or T. A method for providing information for diagnosing sensitivity to vitiligo comprises a step of extracting nucleic acid from a test object and a step of analyzing nucleic acid sequence and detecting the -874th base from a transcription initiation site of TSLP gene. The -874th base is C or T. The sequence analysis is performed through HRM(high resolution melting).
Abstract translation: 目的：提供用于诊断白癜风的TSLP（Thymic基质淋巴细胞生成素），以简单快速地诊断白癜风并增强白癜风的治疗效果。 构成：用于诊断对白癜风敏感性的标记物是包含序列号1]（rs3806933）的多核苷酸。 多核苷酸的SNP位点（单核苷酸多态性）是第27碱基，C或T.提供用于诊断对白癜风敏感性的信息的方法包括从测试对象中提取核酸的步骤和分析核酸序列和 从TSLP基因的转录起始位点检测-874位碱基。 第874个碱基是C或T.序列分析通过HRM（高分辨率熔解）进行。
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公开(公告)号：KR101618950B1
公开(公告)日：2016-05-09
申请号：KR1020140043178
申请日：2014-04-10
Applicant: 동국대학교 산학협력단
Abstract: 본발명은피부자극물질스크리닝용조성물및 이를이용한피부자극물질의스크리닝방법에관한것이다. 본발명의 PI3, CEBPA, SERP INB3, HOPX, SPRR1A, NOD2, LCE3D, CNFN, TMTC1, KRTDAP, ANKRD35, SBSN, BPIL2, RDH12, FLG, H19, FLG2, LOR, IVL, NLRX1, ALDH1A3, DSC2, RHCG, SCEL, IL20, S100A8, S100A9, S100A12, BNIPL, SPRR3, TMEM79, FAM84A, GRHL1, SGPP2, AADACL2, TPRG1, PPP2R2C, SPINK5, ATP10B, GPR110, IL20RA, DEFB1, SLC28A3, AIF1L, CLIC3, NEBL, CARD18, PLBD1, GLTP, TGM1, ZNF750, DSC1, SERPINB13, EMR2, KLK10, COX7A1, SULT2B1 및 KLK7 유전자는피부자극물질로일반적인하이드로퀴논, 레티노산또는 SLS를처리하는경우, 발현양이증가하거나감소함으로써, 상기유전자를이용하여유해한피부자극물질을스크리닝할수 있다. 따라서, 화장품원료물질의동물실험이금지되어이를대체할수 있는피부자극물질을스크링하는방법으로유용하게사용할수 있다.
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公开(公告)号：KR1020140002142A
公开(公告)日：2014-01-08
申请号：KR1020120069739
申请日：2012-06-28
Applicant: 동국대학교 산학협력단
CPC classification number: G01N33/6803 , C12Q1/6883 , C12Q2600/158 , G01N33/5302 , G01N33/5308 , G01N33/6881 , G01N2800/20
Abstract: The invention provides a diagnostic composition of melanocyte-specific retinoic acid stimulation, which includes materials for measuring the level of mRNA or protein of PDZRN3 gene. The expression of PDZRN3 according to the present invention is increased by retinoic acid stimulation and the increase of expression by retinoic acid stimulation does not appear in an independent culture of keratinocytes, but the expression is significantly increased only in melanocytes. Therefore, the invention has an excellent effect to diagnose melanocyte-specific retinoic acid stimulation and is useful for diagnosis of the same.
Abstract translation: 本发明提供黑素细胞特异性视黄酸刺激的诊断组合物，其包括用于测量PDZRN3基因mRNA或蛋白质水平的材料。 根据本发明的PDZRN3的表达通过视黄酸刺激而增加，并且在角质形成细胞的独立培养中不出现视黄酸刺激的表达增加，但是仅在黑素细胞中表达显着增加。 因此，本发明对于诊断黑素细胞特异性视黄酸刺激具有优异的效果，对于诊断为其有用。
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