公开(公告)号：KR100416120B1

公开(公告)日：2004-05-07

申请号：KR1019970060255

申请日：1997-11-15

Applicant: 동화약품주식회사

Inventor： 윤성준 ,  임영희 ,  신동혁 ,  임문정 ,  이덕근

IPC: C07D493/04

Abstract: PURPOSE: An anti-tumor lignan compound isolated from Anthriscus sylvestris HOFFMANN(Umbelliferae) is provided, which compound has similar or improved anti-tumor activity to the prior anti-tumor compounds and no toxicity. CONSTITUTION: The anti-tumor lignan compound isolated from Anthriscus sylvestris HOFFMANN(Umbelliferae) represented by formula (1) is provided. The method for isolating the Anti-tumor lignan compound isolated from Anthriscus sylvestris HOFFMANN(Umbelliferae) of formula (1) comprises the steps of: cutting roots of Anthriscus sylvestris HOFFMANN(Umbelliferae); extracting the cut roots of Anthriscus sylvestris HOFFMANN(Umbelliferae) with methanol in 5 times; fractioning the methanol extract of Anthriscus sylvestris HOFFMANN(Umbelliferae) with solvent of hexane, chloroform, acetic acid ethyl, butanol and water to obtain an active fraction; subjecting the active fraction to silica gel, Sephadex and RP-18 chromatography to obtain anti-tumor compounds; and isolating and purifying an anti-tumor compound, Angeloyl podophyllotoxin, by subjecting the anti-tumor compounds to prep HPLC.

公开(公告)号：KR1019990039985A

公开(公告)日：1999-06-05

申请号：KR1019970060255

申请日：1997-11-15

Applicant: 동화약품주식회사

Inventor： 윤성준 ,  임영희 ,  신동혁 ,  임문정 ,  이덕근

IPC: C07D493/04

Abstract: 본 발명은 전호(
Anthriscus sylvetris HOFFMANN, Umbelliferae)에서 분리한 리그난 계통의 신규 화합물로서 항종양 활성이 우수한 다음 화학식 1의 안젤로일 포도필로톡신(Angeloyl podophyllotoxin) 및 그 추출방법에 관한 것이다.
[화학식 1]