公开(公告)号：KR100592920B1

公开(公告)日：2006-06-23

申请号：KR1020000008695

申请日：2000-02-23

Applicant: 동화약품주식회사

Inventor： 윤성준 ,  유제만 ,  정재희 ,  조수진

IPC: A61K31/196

Abstract: 본 발명은 디클로페낙나트륨 및 폴록사머 혼합물을 포함하고 폴리에틸렌옥사이드 또는 폴리비닐피롤리돈 중에서 선택되어진 1종 이상의 고분자를 포함하는 직장 투여용 조성물로서 직장 투여시 이물감이나 불편함이 없고 투약이 용이하며 투약 후 항문에서 빠져나오지 않고 대장말단으로 이행되지 않는 디클로페낙나트륨을 포함하는 직장 투여용 조성물에 관한 것이다.
직장 투여용 조성물, 디클로페낙나트륨, 폴록사머

公开(公告)号：KR1020010006677A

公开(公告)日：2001-01-26

申请号：KR1020000008695

申请日：2000-02-23

Applicant: 동화약품주식회사

Inventor： 윤성준 ,  유제만 ,  정재희 ,  조수진

IPC: A61K31/196

Abstract: PURPOSE: A composition for rectal administration which contains sodium diclopenac is provided, which is produced easily and cheaply, and has appropriate strength and excellent adhesion activity, so that it is readily administrated via rectum for anti-inflammation, alleviation of pain and removal of fever. CONSTITUTION: The composition comprises 1 to 5 wt.% of sodium diclopenac, 25 to 40 wt.% of two or more solid ploxamer mixture, and 0.1 to 1.0 wt.% of one or more polymer selected from polyethylene oxide and polyvinyl pyrrolidone, in which solid ploxamer mixture contains ploxamer 407 and ploxamer 188 in a weight ratio of 1:1-1.5. The composition optionally contains an antiseptic such as sodium benzoic acid, potassium sorbic acid and parabene, pH adjusting agent such as hydrochloric acid, citric acid, and sodium hydroxide, and stabilizer such as methionine.

Abstract translation: 目的：提供含有二氯代二钠的直肠给药用组合物，其容易且廉价地制造，具有适当的强度和优异的粘附活性，因此可以通过直肠给予，用于抗炎，缓解疼痛和除去发热 。 组成：该组合物包含1至5重量％的二头孢烯酸钠，25至40重量％的两种或更多种固体聚合物混合物和0.1至1.0重量％的一种或多种选自聚环氧乙烷和聚乙烯吡咯烷酮的聚合物， 该固体聚合物混合物含有重量比为1：1-1.5的泊洛沙姆407和泊洛沙姆188。 组合物任选地含有苯甲酸钠，山梨酸钾和对羟基苯甲酸酯等抗菌剂，盐酸，柠檬酸，氢氧化钠等pH调节剂，甲硫氨酸等稳定剂。