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    수-분산성 음이온 폴리머로 이루어진 나노캡슐, 이들의제조 방법, 및 이들을 함유하는 화장품 또는 피부과용조성물
    1.
    发明公开
    수-분산성 음이온 폴리머로 이루어진 나노캡슐, 이들의제조 방법, 및 이들을 함유하는 화장품 또는 피부과용조성물 失效
    包含水分散型阴离子聚合物的纳米颗粒，其制备方法和其包含的化妆品或其组合物

    公开(公告)号：KR1020000048451A

    公开(公告)日：2000-07-25

    申请号：KR1019990063481

    申请日：1999-12-28

    Applicant: 로레알

    Inventor： 리샤르파스칼 ,  시모네쟝-띠에리

    IPC: A61K9/51 ,  B82Y5/00

    CPC classification number: A61K9/5146 ,  A61K8/11 ,  A61K9/5153 ,  A61K2800/413 ,  A61Q19/00 ,  B01J13/04

    Abstract: PURPOSE: A nanocapsule comprising a water-dispersive anionic polymer which effectively protects an active ingredient and makes a manufacturing process of the nanocapsule easy, a method for preparing thereof and a cosmetics or a dermatological composition containing thereof are provided. CONSTITUTION: A nanocapsule comprises: (a) a lipidic core which forms or contains a lipophilic active component; and (b) a water-insoluble, continued polymer envelope, wherein the polymer envelope contains at least one synthetic water-dispersive anionic polymer which is selected from the group consisting of polyester containing a functional group of carboxylic acid and/or sulfonic acid, poly(ester amide), polyurethane and vinyl copolymer and/or a natural water-dispersive anionic polymer which is selected from the group consisting of shellac resin, sandarac gum and dammar resin. The cosmetics or dermatological composition include the nanocapsule in physiologically acceptable carrier. The nanocapsule is prepared by: (i) dissolving a lipidic phase which forms or contains the lipophilic active component and a selective coating agent in an adequate, non-toxic organic solvent having lower boiling point than water; (ii) preparing an aqueous dispersed solution of the water-dispersive anionic polymer; (iii) adding a hydrophilic surfactant to the aqueous dispersed solution of the anionic polymer; (iv) mixing the organic phase prepared from the step (i) with the aqueous phase prepared from the step (iii); and (v) preparing a condensed nanocapsule suspension by evaporating all organic phases and possible, a little aqueous phase.

    Abstract translation: 目的：提供一种纳米胶囊，其包含有效保护活性成分并使纳米胶囊制造过程容易的水分散性阴离子聚合物，其制备方法和含有其的化妆品或皮肤病学组合物。 构成：纳米胶囊包含：（a）形成或含有亲脂性活性成分的脂核; 和（b）水不溶性连续的聚合物包封，其中所述聚合物外壳包含至少一种合成水分散阴离子聚合物，其选自含有羧酸和/或磺酸官能团的聚酯，和 （酯酰胺），聚氨酯和乙烯基共聚物和/或天然水分散阴离子聚合物，其选自虫胶树脂，檀香胶和聚乙烯树脂。 化妆品或皮肤病学组合物包括生理上可接受的载体中的纳米胶囊。 纳米胶囊通过以下制备：（i）将形成或含有亲脂性活性成分和选择性涂层剂的脂质相溶解在沸点低于水的适当的无毒有机溶剂中; （ii）制备水分散性阴离子聚合物的水分散溶液; （iii）向阴离子聚合物的分散水溶液中加入亲水性表面活性剂; （iv）将由步骤（i）制备的有机相与步骤（iii）制备的水相混合; 和（v）通过蒸发所有有机相和可能的少量水相来制备缩合的纳米胶囊悬浮液。

    수-분산성 음이온 폴리머로 이루어진 나노캡슐, 이들의제조 방법, 및 이들을 함유하는 화장품 또는 피부과용조성물
    5.
    发明授权
    수-분산성 음이온 폴리머로 이루어진 나노캡슐, 이들의제조 방법, 및 이들을 함유하는 화장품 또는 피부과용조성물 失效
    수분산온온온로로캡슐캡슐캡슐캡슐캡슐캡슐및및및및및및및및및및및화화화화화화화화화물물물물물물물물물물물물물물물물물물물물물

    公开(公告)号：KR100374421B1

    公开(公告)日：2003-03-04

    申请号：KR1019990063481

    申请日：1999-12-28

    Applicant: 로레알

    Inventor： 리샤르파스칼 ,  시모네쟝-띠에리

    IPC: A61K9/51 ,  B82Y5/00

    CPC classification number: A61K9/5146 ,  A61K8/11 ,  A61K9/5153 ,  A61K2800/413 ,  A61Q19/00 ,  B01J13/04

    Abstract: Nanocapsules comprising the following components are new: (a) a lipid core comprising a lipophilic active ingredient (I); and (b) a water-insoluble shell comprising a water-dispersible anionic polymer (II) selected from polyesters, poly(ester amides), polyurethanes, vinyl copolymers, shellac, sandarac gum and dammars. Independent claims are also included for the following: (1) a cosmetic or dermatological composition containing the nanocapsules in a carrier; (2) a process for producing the nanocapsules, comprising: (i) dissolving a lipid phase comprising (I) and optionally a coating agent in a nontoxic organic solvent having a lower boiling point than water; (ii) preparing an aqueous dispersion of (II); (iii) adding a hydrophilic surfactant to the dispersion; (iv) combining the organic phase of (i) with the organic phase of (iii); and (v) evaporating the organic solvent and optionally part of the aqueous phase; (3) a process for producing the nanocapsules, comprising: (i) dissolving (II), a lipid phase comprising (I) and optionally a coating agent in a water-miscible organic solvent; (ii) pouring the solution into an aqueous surfactant solution; and (iii) evaporating the organic solvent and optionally part of the aqueous phase.

    Abstract translation: 包含以下组分的纳米胶囊是新的：（a）包含亲脂性活性成分（I）的脂质核; 和（b）水不溶性壳，其包含选自聚酯，聚（酯酰胺），聚氨酯，乙烯基共聚物，虫胶，砂糖树胶和阻尼剂的水分散性阴离子聚合物（II）。 独立权利要求还包括以下内容：（1）在载体中含有纳米胶囊的化妆品或皮肤病学组合物; （2）制备纳米胶囊的方法，其包括：（i）将包含（I）和任选的涂布剂的脂质相溶解在沸点低于水的无毒有机溶剂中; （ii）制备（II）的水分散体; （iii）向分散体中加入亲水性表面活性剂; （iv）将（i）的有机相与（iii）的有机相合并; 和（v）蒸发有机溶剂和任选的部分水相; （3）制备纳米胶囊的方法，其包括：（i）将（II），包含（I）和任选的涂布剂的脂质相溶解在可与水混溶的有机溶剂中; （ii）将该溶液倒入表面活性剂水溶液中; 和（iii）蒸发有机溶剂和任选的部分水相。

    폴리(알킬렌 아디페이트)로 이루어진 나노캡슐, 이들의제조 방법, 및 이들을 함유하는 화장품 또는 피부과용조성물
    6.
    发明公开
    폴리(알킬렌 아디페이트)로 이루어진 나노캡슐, 이들의제조 방법, 및 이들을 함유하는 화장품 또는 피부과용조성물 失效
    包含聚（亚烷基二醇）的纳米油墨，其制备方法和包含其的化妆品或其组合物

    公开(公告)号：KR1020000048452A

    公开(公告)日：2000-07-25

    申请号：KR1019990063482

    申请日：1999-12-28

    Applicant: 로레알

    Inventor： 시모네쟝-띠에리 ,  리샤르파스칼 ,  비아뜨리브루노

    IPC: A61K9/51 ,  B82Y5/00

    CPC classification number: A61K9/5146 ,  A61K8/11 ,  A61K9/5153 ,  A61K9/5161 ,  A61K2800/413 ,  A61Q19/00 ,  B01J13/04 ,  Y10S977/727 ,  Y10S977/797 ,  Y10S977/896 ,  Y10S977/915 ,  Y10S977/926

    Abstract: PURPOSE: A nanocapsule comprising poly(alkylene adipate) which effectively protects an active ingredient and makes a manufacturing process of the nanocapsule easy, a method for preparing thereof and a cosmetics or a dermatological composition containing thereof are provided. CONSTITUTION: A nanocapsule comprises: (a) a lipidic core which forms or contains a lipophilic active component; and (b) a water-insoluble, continued polymer envelope, wherein the polymer envelope contains at least one linear or branched polyester of poly(alkylene adipate) including an unit derived from an adipic acid and an unit derived from more than one alkane-diol and/or more than one ether-diol and/or more than one triol. The cosmetics or dermatological composition include the nanocapsule of poly(alkylene adipate) in physiologically acceptable carrier. The nanocapsule is prepared by: (i) dissolving poly(alkylene adipate), lipidic phase which forms or contains lipophilic active component and an optional coating agent in an adequate, water-miscible organic solvent; (ii) preparing an aqueous solution of an adequate surfactant; (iii) adding the organic phase prepared from the step (i) to the aqueous phase prepared from the step (ii) with stirring at a proper speed; and (iv) evaporating all organic phases and possible, a little aqueous phase.

    Abstract translation: 目的：提供一种包含聚（亚烷基己二酸酯）的纳米胶囊，其有效保护活性成分并使纳米胶囊的制造过程容易，其制备方法和含有其的化妆品或皮肤病学组合物。 构成：纳米胶囊包含：（a）形成或含有亲脂性活性成分的脂核; 和（b）水不溶性连续的聚合物外壳，其中聚合物外壳包含至少一种包含衍生自己二酸的单元的聚（亚烷基己二酸酯）的直链或支链聚酯和衍生自多于一种烷烃二醇的单元 和/或多于一种醚 - 二醇和/或多于一种三醇。 化妆品或皮肤病学组合物包括在生理上可接受的载体中的聚（亚烷基己二酸酯）的纳米胶囊。 纳米胶囊通过以下方法制备：（i）将聚（亚烷基己二酸酯），形成或含有亲脂性活性成分的脂质相和任选的涂布剂溶解在足够的与水混溶的有机溶剂中; （ii）制备足够表面活性剂的水溶液; （iii）将以步骤（i）制备的有机相以适当速度搅拌加入到由步骤（ii）制备的水相中; 和（iv）蒸发所有有机相和可能的少量水相。

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