公开(公告)号：KR1020130073280A

公开(公告)日：2013-07-03

申请号：KR1020110141045

申请日：2011-12-23

Applicant: 삼육대학교산학협력단

Inventor： 하남주 ,  이강오

IPC: A61K35/74 ,  A61P31/12

Abstract: PURPOSE: Bifidobacterium adolescentis SPM 1005-A and Bifidobacterium pseudocatenulatum SPM 1204, and a composition using the same for preventing or treating human pailloma virus (HPV) infectious diseases are provided to suppress the activity of HPV type 16, to enhance cross-presentation of dendritic cells, to induce NO and TNF-alpha production, and to effectively suppress uterine cervix cancer. CONSTITUTION: A composition for preventing or treating HPV infectious diseases contains Bifidobacterium adolescentis SPM1005-A, Bifidobacterium pseudocatenulatum SPM 1204, or a culture thereof as an active ingredient. Bifidobacterium adolescentis SPM1005-A and Bifidobacterium pseudocatenulatum SPM 1204 are mixed in a weight ratio of 1:0.5-0.7. Bifidobacterium adolescentis SPM1005-A, Bifidobacterium pseudocatenulatum SPM 1204 are probiotics, killed bacteria, or a combination thereof. The composition is a pharmaceutical composition, a food composition, or a quasi drug composition.

Abstract translation: 目的：提供双歧杆菌青少年SPM 1005-A和假双孢杆菌SPM 1204，以及使用该组合物预防或治疗人类白斑病毒（HPV）感染性疾病的组合物，以抑制HPV16型的活性，增强树突状细胞的交叉表现 细胞，诱导NO和TNF-α产生，并有效抑制子宫颈癌。 构成：用于预防或治疗HPV感染性疾病的组合物含有青春双歧杆菌SPM1005-A，假双孢杆菌SPM 1204或其培养物作为活性成分。 双歧杆菌青少年SPM1005-A和假双孢杆菌SPM 1204以1:0.5-0.7的重量比混合。 双歧杆菌青少年SPM1005-A，假双孢杆菌SPM 1204是益生菌，杀死细菌或其组合。 组合物是药物组合物，食物组合物或准药物组合物。

公开(公告)号：KR1020130070963A

公开(公告)日：2013-06-28

申请号：KR1020110138244

申请日：2011-12-20

Applicant: 삼육대학교산학협력단

Inventor： 하남주 ,  이강오

IPC: A61K35/74 ,  A61K35/76 ,  A61P31/12

Abstract: PURPOSE: A composition for suppressing HSV(Herpes Simplex Virus) is provided to effectively suppress HSV by enhancing immunity of Bifidobacterium adolescentis SPM 0214 and Bifidobacterium pseudocatenulatum SPM 1204. CONSTITUTION: A composition for suppressing HSV contains Bifidobacterium adolescentis SPM 0214(KCTC 11668BP) and Bifidobacterium pseudocatenulatum SPM 1204(deposit number KCTC 10616BP) which are mixed in a ratio of 1: 0.2 to 1:0.5. Bifidobacterium adolescentis SPM 0214 hardly affects cell survival.

Abstract translation: 目的：提供一种用于抑制HSV（单纯疱疹病毒）的组合物，通过增强青春双歧杆菌SPM 0214和假双孢杆菌SPM 1204的免疫力来有效抑制HSV。构成：用于抑制HSV的组合物含有青春双歧杆菌SPM 0214（KCTC 11668BP）和双歧杆菌 假单胞菌属SPM 1204（保藏号KCTC 10616BP）以1:0.2至1:0.5的比例混合。 双歧杆菌青春期SPM 0214几乎不影响细胞存活。

公开(公告)号：KR101062779B1

公开(公告)日：2011-09-06

申请号：KR1020100039553

申请日：2010-04-28

Applicant: 삼육대학교산학협력단

Inventor： 하남주 ,  이강오

IPC: C12N1/20 ,  A61K35/74 ,  A23L1/30

CPC classification number: C12N1/20 ,  A23L33/10 ,  A23L33/135 ,  A61K35/74

Abstract: 본 발명은 충치 유발 세균의 성장 억제 활성을 나타내는 신규한 비피도박테리움 아돌레센티스(
Bifidobacterium adolescentis ) SPM1005 (기탁번호 :KCTC 11670BP)균주 및 상기 SPM1005 또는 이의 배양물을 유효성분으로 하는 충치 예방용 조성물에 관한 것이다.
본 발명의 비피도박테리움 아돌레센티스(
Bifidobacterium adolescentis ) SPM1005 (기탁번호 :KCTC 11670BP) 균주 및 상기 SPM1005 균주 또는 이의 배양물을 유효 성분으로 하는 충치 예방용 조성물은, 충치 유발 세균에 대해 특이적이고 우수한 생육 억제 활성을 보이기 때문에, 이를 충치 치료에 활용할 경우 종래 충치의 치료에 있어 항생제 처리 등에 의해 발생하는 문제점과 부작용을 최소화할 수 있을 뿐만 아니라, 건강 보조 식품, 식품, 또는 식품 이외에도 발효 제품, 의약품 및 의약외품 등에 응용이 가능하다.

公开(公告)号：KR1020110065128A

公开(公告)日：2011-06-15

申请号：KR1020090121995

申请日：2009-12-09

Applicant: 삼육대학교산학협력단

Inventor： 하남주 ,  이강오 ,  이도경 ,  장석 ,  안향미 ,  백은혜 ,  김미진 ,  김정래

IPC: C12N1/20 ,  A01N63/02

Abstract: PURPOSE: A probiotic composition containing Bifidobacterium pseudocatenulatum SPM1204 Lactobacillus or culture thereof is provided to promote livestock growth and to be used in manufacturing foods. CONSTITUTION: A probiotic composition for livestock contains Bifidobacterium pseudocatenulatum SPM12-4 Lactobacillus(deposit number: KCTC 10616BP) or culture thereof as an active ingredient. The probiotic composition contains Lactobacillus of Lactobacillus acidophilus or Pediococcus pentosaceus or culture thereof. The probiotic composition has an effect of cleaning intestine against Salmonella gallinarum, Salmonella enteritidis, Salmonella typhimurium, Staphylococcus aureus, E. coli, Listeria monocytogenes, Campylobacter jejuni, and Clostridium perfringens. The livestock is calf.

Abstract translation: 目的：提供含有假双孢杆菌SPM1204的益生菌组合物乳杆菌或其培养物以促进家畜生长并用于制造食品。 构成：家禽用益生菌组合物含有假双孢杆菌SPM12-4乳杆菌（保藏号：KCTC 10616BP）或其培养物作为活性成分。 益生菌组合物含有嗜酸乳杆菌或戊糖片球菌的乳杆菌或其培养物。 益生菌组合物具有清除肠对沙门氏菌，肠炎沙门氏菌，鼠伤寒沙门氏菌，金黄色葡萄球菌，大肠杆菌，单核细胞增多性李斯特菌，空肠弯曲杆菌和产气荚膜梭菌的肠的作用。 家畜是小牛。

公开(公告)号：KR1020130040675A

公开(公告)日：2013-04-24

申请号：KR1020110105707

申请日：2011-10-17

Applicant: 삼육대학교산학협력단

Inventor： 하남주 ,  이강오

IPC: C12N1/20 ,  A61K35/74 ,  A61P31/12

Abstract: PURPOSE: A composition containing Bifidobacterium adolesentis SPM 1005-A or a culture thereof for preventing or treating human papilloma virus(HPV) infection by effectively suppressing HPV. CONSTITUTION: Bifidobacterium adolesentis SPM 1005-A(KCTC 12014BP) suppresses HPV type 16. The strain also suppresses expression of HPV E6 and E7 proteins. A composition for preventing or treating HPV infection contains the strain or a culture thereof as an active ingredient. The composition suppresses HPV type 16 and expression of HPV E6 and E7. The composition is a pharmaceutical composition or a quasi-drug composition.

Abstract translation: 目的：含有双歧杆菌SPM 1005-A或其有效抑制HPV的预防或治疗人乳头状瘤病毒（HPV）感染的培养物的组合物。 构成：双歧杆菌SPM 1005-A（KCTC 12014BP）抑制HPV16型。该菌株还抑制HPV E6和E7蛋白的表达。 用于预防或治疗HPV感染的组合物含有作为活性成分的菌株或其培养物。 该组合物抑制HPV 16型和HPV E6和E7的表达。 组合物是药物组合物或准药物组合物。

公开(公告)号：KR101068079B1

公开(公告)日：2011-09-28

申请号：KR1020100066785

申请日：2010-07-12

Applicant: 삼육대학교산학협력단

Inventor： 하남주 ,  이강오

IPC: C12N1/20 ,  A61K35/74 ,  A61K35/745 ,  C12R1/01

CPC classification number: C12N1/20 ,  A61K35/74 ,  A61K35/745 ,  C12R1/01

Abstract: 본 발명은 단순포진바이러스에 대한 항바이러스 활성을 나타내는 유산균 SPM 0214 (KCTC 11668 BP) 및 상기 유산균 SPM 0214 (KCTC 11668 BP) 또는 이의 배양물을 유효 성분으로 함유하는 단순 포진 바이러스 감염의 예방 또는 치료용 조성물에 관한 것이다.

公开(公告)号：KR1020100011813A

公开(公告)日：2010-02-03

申请号：KR1020080073186

申请日：2008-07-25

Applicant: 삼육대학교산학협력단

Inventor： 하남주 ,  이강오 ,  이도경 ,  양환진 ,  장석 ,  안향미 ,  백은혜

IPC: A61K35/744 ,  A61K35/745 ,  A61K35/747 ,  A23L33/00

CPC classification number: A61K35/744 ,  A23L33/00 ,  A61K35/745 ,  A61K35/747

Abstract: PURPOSE: A lactobacillus composition having effect of preventing and treating constipation is provided to suppress harmful enzyme inside intestine and improve defecation form. CONSTITUTION: A lactobacillus composition is produced by culturing lactobacillus of Bifidobacterium longum SPM1205(KCTC 10630BP), Lactobacillus acidophilus and Pediococcus pentosaceus, pulverizing the culture liquid and mixing lactobacillus of powder form. The lactobacillus composition has an effect of preventing and treating constipation by suppressing activation of harmful enzyme inside intestine. The harmful enzyme is beta-glucosidase, beta-glucuronidase, tryptopanase and urease. A composition for treating and preventing constipation contains the lactobacillus composition as an active ingredient.

Abstract translation: 目的：提供具有预防和治疗便秘作用的乳杆菌组合物，以抑制肠内的有害酶，改善排便形式。 构成：通过培养长双歧杆菌SPM1205（KCTC 10630BP），嗜酸乳杆菌和戊糖片球菌的乳杆菌来制备乳杆菌组合物，粉碎培养液并混合粉末形式的乳酸杆菌。 乳杆菌组合物通过抑制肠内有害酶的活化而具有预防和治疗便秘的作用。 有害的酶是β-葡糖苷酶，β-葡糖苷酸酶，曲妥坦酵素酶和尿素酶。 用于治疗和预防便秘的组合物含有乳杆菌组合物作为活性成分。

公开(公告)号：KR1020150009015A

公开(公告)日：2015-01-26

申请号：KR1020130079832

申请日：2013-07-08

Applicant: 삼육대학교산학협력단

Inventor： 하남주 ,  이강오 ,  김경제 ,  이도경

IPC: C12N1/20 ,  A61K35/74 ,  A61K35/745 ,  A23L1/30

CPC classification number: C12N1/20 ,  A23L33/135 ,  A61K35/74 ,  A61K35/745

Abstract: 본 발명은 콕사키바이러스에 대한 항바이러스 활성을 갖는 신규 유산균에 관한 것으로서, 보다 상세하게는 콕사키바이러스 B3(Coxsackie virus B3; CVB3)에 대해 항바이러스 활성을 나타내는 비피도박테리움 아돌레센티스 SPM 1605(
Bifidobacterium
adolescentis

SPM
1605)에 관한 것이다.
본 발명에 의한 비피도박테리움 아돌레센티스 SPM 1605(
Bifidobacterium
adolescentis
SPM
1605)은 장내에서 분리된 유산균이면서도 콕사키바이러스 B3에 대해 우수한 항바이러스 활성을 나타냄에 따라 프로바이오틱스 등의 항바이러스 조성물에 응용할 수 있다.

Abstract translation: 本发明涉及对柯萨奇病毒具有抗病毒活性的新型乳酸菌，更具体地说涉及对柯萨奇病毒B3（CVB3）具有抗病毒活性的青春双歧杆菌SPM 1605。 根据本发明的青春双歧杆菌SPM 1605是从肠中分离的乳酸菌，对CVB3显示出增强的抗病毒活性，从而适用于益生菌等抗病毒组合物。

公开(公告)号：KR101434220B1

公开(公告)日：2014-08-28

申请号：KR1020130031835

申请日：2013-03-26

Applicant: 삼육대학교산학협력단

Inventor： 하남주 ,  이강오 ,  김경제 ,  이도경

IPC: C12N1/20 ,  A61K39/02 ,  A61P31/04

Abstract: The present invention relates to a novel lactic acid bacteria having an inhibitory activity against a multidrug resistant bacteria and, more particularly, to a novel lactic acid bacteria of the Bifidobacterium pseudocatenulatum SPM 1309 having an inhibitory activity against the multidrug resistant bacteria of the Acinetobacter baumannii and the Pseudomonas aeruginosa.

Abstract translation: 本发明涉及对多药耐药细菌具有抑制活性的新型乳酸菌，更具体地说，涉及对鲍曼不动杆菌的多重耐药性细菌具有抑制活性的双歧杆菌假性囊杆菌SPM 1309的新型乳酸菌，以及 铜绿假单胞菌（Pseudomonas aeruginosa）。

公开(公告)号：KR1020130074825A

公开(公告)日：2013-07-05

申请号：KR1020110141285

申请日：2011-12-23

Applicant: 삼육대학교산학협력단

Inventor： 하남주 ,  이강오

IPC: A61K36/48 ,  A61P17/00

CPC classification number: Y02A50/473 ,  Y02A50/481 ,  A61K36/48 ,  A61K2236/19 ,  A61K2236/331 ,  A61K2236/333 ,  Y10S514/859

Abstract: PURPOSE: An anti-acne composition containing a germinated soybean extract and lactic acid bacteria which suppresses Propionibacterium acnes is provided to specifically suppress P. acnes which cause acne, to ensure antibacterial action against P. acne and harmful bacteria, and to prevent and treat acne diseases. CONSTITUTION: An anti-acne composition contains a germinated soybean extract and lactic acid bacteria which suppress Propionibacterium acnes. The extract is prepared using water, C1-C5 alcohols, propylene glycol, 1,3-butylene glycol, or a mixture thereof. The antibacterial composition has an antibacterial activity against one or more selected from the group consisting of E.coli, Salmonella typhimurium, Staphyllococcus aureus, Candida albican, Aspergillus niger, and Propionibacterium acnes. The lactic acid bacteria are Bipidobacterium lactobacillus SPM0308 (KCTC 11669BP). A drug, a health functional food, or a cosmetic composition contains the composition.

Abstract translation: 目的：提供含有发芽大豆提取物和抑制丙酸杆菌的乳酸菌的抗痤疮组合物，以特异性抑制引起痤疮的痤疮丙酸杆菌，以确保对痤疮粉刺和有害细菌的抗菌作用，并预防和治疗痤疮 疾病。 构成：抗痤疮组合物含有抑制丙酸杆菌的发芽大豆提取物和乳酸菌。 提取物是使用水，C1-C5醇，丙二醇，1,3-丁二醇或其混合物制备的。 所述抗菌组合物对选自大肠杆菌，鼠伤寒沙门氏菌，金黄色葡萄球菌，白念珠菌，黑曲霉和痤疮丙酸杆菌中的一种或多种具有抗菌活性。 乳酸菌是乳杆菌SPM0308（KCTC 11669BP）。 药物，保健功能食品或化妆品组合物含有该组合物。