염기를 고체 상태로 이용하는 불균일상 [18F]유기플루오로 화합물의 제조방법
    2.
    发明公开
    염기를 고체 상태로 이용하는 불균일상 [18F]유기플루오로 화합물의 제조방법 有权
    在固体状态下使用基础的[18 F]氟化有机化合物的异构体制备

    公开(公告)号:KR1020120084182A

    公开(公告)日:2012-07-27

    申请号:KR1020110005578

    申请日:2011-01-19

    Abstract: PURPOSE: A method for preparing [18F] organic fluoro compounds is provided to induce heterogenous nucleophilicity [18F] fluorination and to minimize base concentration in a solution. CONSTITUTION: A method for preparing [18F] organic fluoro compounds comprises nucleophilicity [18F] fluorination of reaction formula 1 using a base of chemical formula 1(M_nA_m) and deprotection process. A solvent of reaction formula 1 is acetone, tetrahydrofuran, 1,4-dioxane, 1,2-dimethoxy ethane, benzene, toluene, acetonitrile, dimethyl formamide, dimethyl acetamide, dimethyl sulfoxide, or alcohol solvent.

    Abstract translation: 目的:提供制备[18 F]有机氟化合物的方法,以诱导异质亲核性[18 F]氟化,并使溶液中的碱浓度降至最低。 构成:制备[18 F]有机氟化合物的方法包括使用化学式1(M_nA_m)的碱和脱保护过程的反应式1的亲核试剂[18 F]氟化。 反应式1的溶剂是丙酮,四氢呋喃,1,4-二恶烷,1,2-二甲氧基乙烷,苯,甲苯,乙腈,二甲基甲酰胺,二甲基乙酰胺,二甲基亚砜或醇溶剂。

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