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Patent Agency Ranking
公开(公告)号：KR1020140066674A
公开(公告)日：2014-06-02
申请号：KR1020140035617
申请日：2014-03-26
Applicant: 서강대학교산학협력단
IPC: G01N33/573 , C12Q1/26 , C12Q1/68
Abstract: The present invention relates to a sensor for detecting tyrosine hydroxylase comprising; (a) a magnetic particle in which a first antibody for the tyrosine hydroxylase is conjugated; and (b) a gold nanoparticle in which a second antibody for the tyrosine hydroxylase and first oligonucleotide are conjugated and a barcode DNA having a complementary sequence with the first oligonucleotide is hybridized with the first oligonucleotide. According to the present invention, the sensor for detecting the tyrosine hydroxylase is a sensor for detecting the initial neurotransmission-related enzyme and provides high sensitivity to detect less than 0.2 ng/ml of the tyrosine hydroxylase. Therefore, the sensor for detecting the tyrosine hydroxylase of the present invention easily and rapidly detects the tyrosine hydroxylase and diagnoses nerve disorders such as Parkinson′s disease at an early stage.
Abstract translation: 本发明涉及一种检测酪氨酸羟化酶的传感器，包括： （a）其中结合有酪氨酸羟化酶的第一抗体的磁性颗粒; 和（b）金纳米颗粒，其中将酪氨酸羟化酶和第一寡核苷酸的第二抗体缀合，并且与第一寡核苷酸具有互补序列的条形码DNA与第一寡核苷酸杂交。 根据本发明，用于检测酪氨酸羟化酶的传感器是用于检测初始神经传递相关酶的传感器，并且提供高灵敏度以检测小于0.2ng / ml的酪氨酸羟化酶。 因此，用于检测本发明的酪氨酸羟化酶的传感器容易且快速地检测酪氨酸羟化酶，并且在早期阶段诊断诸如帕金森病的神经障碍。
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公开(公告)号：KR1020130121550A
公开(公告)日：2013-11-06
申请号：KR1020120044853
申请日：2012-04-27
Applicant: 서강대학교산학협력단
IPC: G01N33/573 , C12Q1/26 , G01N33/551 , C12Q1/68
CPC classification number: G01N33/573 , C12Q1/26 , C12Q1/686 , C12Q2563/185 , G01N33/551
Abstract: The present invention relates to a sensor for detecting tyrosine hydrolase, comprising: a magnetic particle conjugated to a first antibody against tyrosine hydrolase; and gold nanoparticles which are conjugated to a second antibody against tyrosine hydrolase and a first oligonucleotide which is hybridized with a barcode DNA with a sequence complementary with the first oligonucleotide. According to the present invention, the sensor for detecting tyrosine hydrolase is used for detecting the first neurotransmission-related enzymes and has high sensitivity, capable of detecting 0.2 ng/ml or less of tyrosine hydrolase. Accordingly, the sensor quickly and easily detects tyrosine hydrolase, thereby early diagnosing neurological disorders such as Parkinson’s disease.
Abstract translation: 本发明涉及一种用于检测酪氨酸水解酶的传感器，包括：与抗酪氨酸水解酶的第一抗体缀合的磁性颗粒; 和与第二抗体相对抗酪氨酸水解酶的金纳米颗粒和第一寡核苷酸，其与条形码DNA与第一寡核苷酸互补的序列杂交。 根据本发明，用于检测酪氨酸水解酶的传感器用于检测第一神经传递相关酶，并且具有高灵敏度，能够检测0.2ng / ml或更少的酪氨酸水解酶。 因此，传感器快速且容易地检测酪氨酸水解酶，从而早期诊断诸如帕金森病的神经障碍。
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公开(公告)号：KR101360405B1
公开(公告)日：2014-02-11
申请号：KR1020120037370
申请日：2012-04-10
Applicant: 서강대학교산학협력단
Abstract: 본 발명은 신경전달-관련 물질 검출용 센서에 관한 것으로, (a) 신경전달-관련 물질에 대한 제1항체가 결합된 마이크로어레이 칩 판; (b) 상기 신경전달-관련 물질과 동일한 신경전달-관련 물질에 대한 제2항체 및 바코드 DNA가 결합된 금 나노입자; 및 (c) 상기 바코드 DNA에 상보적인 서열을 갖는 상보적 DNA가 표면 상에 고정화 된 금속 나노 패턴을 갖는 금속 나노 기판을 포함하는 신경전달-관련 물질 검출용 센서를 제공한다.
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公开(公告)号：KR101408305B1
公开(公告)日：2014-06-18
申请号：KR1020140035617
申请日：2014-03-26
Applicant: 서강대학교산학협력단
IPC: G01N33/573 , C12Q1/26 , C12Q1/68
Abstract: 본 발명은 (a) 티로신 수산화효소에 대한 제1항체가 결합된 자성입자; 및 (b) 상기 티로신 수산화효소에 대한 제2항체 및 제1올리고뉴클레오타이드가 결합되어 있고 상기 제1올리고뉴클레오타이드에 상보적인 서열을 갖는 바코드 DNA가 상기 제1올리고뉴클레오타이드에 혼성화 되어 있는 금 나노입자를 포함하는 티로신 수산화효소 검출용 센서에 관한 것이다. 본 발명에 따르면, 본 발명은 티로신 수산화효소 검출용 센서는 최초의 신경전달-관련 효소 검출용 센서이이며, 0.2 ng/㎖ 미만의 티로신 수산화효소도 검출할 수 있는 고도의 민감성을 제공한다. 따라서, 본 발명의 티로신 수산화효소 검출용 센서는 신속하고 용이하게 티로신 수산화효소를 검출하여 파킨슨씨 질병과 같은 신경질환을 조기에 진단할 수 있다.
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公开(公告)号：KR1020130114932A
公开(公告)日：2013-10-21
申请号：KR1020120037370
申请日：2012-04-10
Applicant: 서강대학교산학협력단
Abstract: PURPOSE: A sensor for detecting neurotransmission-related substances is provided to have marked sensitivity in comparison with a conventional polymerase chain reaction (PCR) method. CONSTITUTION: A sensor for detecting neurotransmission-related substances comprises: a microarray chip board in which first antibodies against neurotransmission-related substances are combined; gold nanoparticles in which second antibodies against the neurotransmission-related substances and bar code DNA are combined; and a metal nano substrate including metal nano patterns in which complementary DNA (cDNA) having a sequence complementary to the bar code DNA is fixed on the surface.
Abstract translation: 目的：提供一种用于检测神经传递相关物质的传感器，与传统的聚合酶链反应（PCR）方法相比具有明显的灵敏度。 构成：用于检测神经传递相关物质的传感器包括：组合有针对神经传递相关物质的第一抗体的微阵列芯片板; 金纳米颗粒，其中针对神经传递相关物质和条形码DNA的第二抗体组合; 以及包含金属纳米图案的金属纳米基质，其中具有与条形码DNA互补的序列的互补DNA（cDNA）固定在表面上。
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