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公开(公告)号：WO2016204407A1
公开(公告)日：2016-12-22
申请号：PCT/KR2016/004959
申请日：2016-05-12
Applicant: 서강대학교산학협력단
IPC: C02F3/10 , C02F1/62 , C02F3/34 , C02F101/20 , C02F103/08
Abstract: 본 발명은 해양 중금속 제거용 미생물담체를 이용하여 해수 퇴적 오염물로부터 중금속을 제거하는 생물학적 피복 정화 방법에 관한 것이다. 본 발명은 해수 중금속 제거용 미생물담체를 이용하여 현장에서 바로 오염 퇴적물을 정화할 수 있는 현장 정화 기술(on-situ)을 제공할 수 있다. 본 발명의 해양 오염 퇴적물 처리 방법은 화학적 방법을 통한 공정을 거치지 않아 2차 오염의 우려가 없고 해양 생태계 교란을 방지할 수 있다. 본 발명의 해양 오염 퇴적물 처리 방법은 저비용 고효율의 환경 친화적 방법으로서 준설공법을 대체할 수 있을 것으로 예상된다.
Abstract translation: 本发明涉及通过使用微生物培养基去除海洋重金属从海洋沉积物中的污染物中除去重金属的生物覆盖物净化方法。 本发明可以提供一种能够通过使用微生物介质去除海洋重金属而在现场净化污染沉积物的原位净化技术。 本发明的海洋污染沉积物处理方法对二次污染没有担心，可以防止海洋生态系统的干扰，因为该方法不能用化学方法进行处理。 本发明的海洋污染沉积物的处理方法是低成本，高效，环保的方法，因此可以取代疏浚方法。
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公开(公告)号：KR101622477B1
公开(公告)日：2016-05-31
申请号：KR1020140141432
申请日：2014-10-20
Applicant: 서강대학교산학협력단
IPC: G01N33/573 , G01N33/543
Abstract: 본발명은간편하고신속하게타겟물질을고감도로감지할수 있는효소면역측정용효소볼 및이의제조방법에관한것이다. 본발명에따른효소면역측정용효소볼은내부에많은양의효소를캡슐화하고있고, 또한내부로기질이유입될수 있어많은양의효소가기질과반응할수 있으므로항원검출의감도를높일수 있다. 또한, 본발명의효소볼은생분해성이고, 탈용매법으로쉽게제조할수 있고, 또한, 효소볼은항체, 약물, 형광물질과같은다양한물질과효과적으로결합될수 있으므로적용범위가매우광범위하다.
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Patent Agency Ranking
公开(公告)号：KR1020150145191A
公开(公告)日：2015-12-29
申请号：KR1020150085001
申请日：2015-06-16
Applicant: 서강대학교산학협력단
IPC: C02F3/10 , C02F1/62 , C02F3/34 , C02F101/20 , C02F103/08
Abstract: 본발명은해양중금속제거용미생물담체를이용하여해수퇴적오염물로부터중금속을제거하는생물학적피복정화방법에관한것이다. 본발명은해수중금속제거용미생물담체를이용하여현장에서바로오염퇴적물을정화할수 있는현장정화기술(on-situ)을제공할수 있다. 본발명의해양오염퇴적물처리방법은화학적방법을통한공정을거치지않아 2차오염의우려가없고해양생태계교란을방지할수 있다. 본발명의해양오염퇴적물처리방법은저비용고효율의환경친화적방법으로서준설공법을대체할수 있을것으로예상된다.
Abstract translation: 本发明涉及使用微生物载体去除海洋重金属从海水沉积污染中去除重金属的生物覆盖物净化方法。 本发明提供了一种能够使用微生物载体净化田间污染的沉积物以去除海洋重金属的原位净化技术。 海洋污染沉积物的处理方法由于不通过化学方法的过程而不会发生二次污染，可以防止海洋生态系统的干扰。 此外，海洋污染的沉积物的处理方法预计能够以低成本，高效率的环保方式代替疏浚方法。
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公开(公告)号：KR1020140066674A
公开(公告)日：2014-06-02
申请号：KR1020140035617
申请日：2014-03-26
Applicant: 서강대학교산학협력단
IPC: G01N33/573 , C12Q1/26 , C12Q1/68
Abstract: The present invention relates to a sensor for detecting tyrosine hydroxylase comprising; (a) a magnetic particle in which a first antibody for the tyrosine hydroxylase is conjugated; and (b) a gold nanoparticle in which a second antibody for the tyrosine hydroxylase and first oligonucleotide are conjugated and a barcode DNA having a complementary sequence with the first oligonucleotide is hybridized with the first oligonucleotide. According to the present invention, the sensor for detecting the tyrosine hydroxylase is a sensor for detecting the initial neurotransmission-related enzyme and provides high sensitivity to detect less than 0.2 ng/ml of the tyrosine hydroxylase. Therefore, the sensor for detecting the tyrosine hydroxylase of the present invention easily and rapidly detects the tyrosine hydroxylase and diagnoses nerve disorders such as Parkinson′s disease at an early stage.
Abstract translation: 本发明涉及一种检测酪氨酸羟化酶的传感器，包括： （a）其中结合有酪氨酸羟化酶的第一抗体的磁性颗粒; 和（b）金纳米颗粒，其中将酪氨酸羟化酶和第一寡核苷酸的第二抗体缀合，并且与第一寡核苷酸具有互补序列的条形码DNA与第一寡核苷酸杂交。 根据本发明，用于检测酪氨酸羟化酶的传感器是用于检测初始神经传递相关酶的传感器，并且提供高灵敏度以检测小于0.2ng / ml的酪氨酸羟化酶。 因此，用于检测本发明的酪氨酸羟化酶的传感器容易且快速地检测酪氨酸羟化酶，并且在早期阶段诊断诸如帕金森病的神经障碍。
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公开(公告)号：KR1020130121550A
公开(公告)日：2013-11-06
申请号：KR1020120044853
申请日：2012-04-27
Applicant: 서강대학교산학협력단
IPC: G01N33/573 , C12Q1/26 , G01N33/551 , C12Q1/68
CPC classification number: G01N33/573 , C12Q1/26 , C12Q1/686 , C12Q2563/185 , G01N33/551
Abstract: The present invention relates to a sensor for detecting tyrosine hydrolase, comprising: a magnetic particle conjugated to a first antibody against tyrosine hydrolase; and gold nanoparticles which are conjugated to a second antibody against tyrosine hydrolase and a first oligonucleotide which is hybridized with a barcode DNA with a sequence complementary with the first oligonucleotide. According to the present invention, the sensor for detecting tyrosine hydrolase is used for detecting the first neurotransmission-related enzymes and has high sensitivity, capable of detecting 0.2 ng/ml or less of tyrosine hydrolase. Accordingly, the sensor quickly and easily detects tyrosine hydrolase, thereby early diagnosing neurological disorders such as Parkinson’s disease.
Abstract translation: 本发明涉及一种用于检测酪氨酸水解酶的传感器，包括：与抗酪氨酸水解酶的第一抗体缀合的磁性颗粒; 和与第二抗体相对抗酪氨酸水解酶的金纳米颗粒和第一寡核苷酸，其与条形码DNA与第一寡核苷酸互补的序列杂交。 根据本发明，用于检测酪氨酸水解酶的传感器用于检测第一神经传递相关酶，并且具有高灵敏度，能够检测0.2ng / ml或更少的酪氨酸水解酶。 因此，传感器快速且容易地检测酪氨酸水解酶，从而早期诊断诸如帕金森病的神经障碍。
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公开(公告)号：KR1020090072356A
公开(公告)日：2009-07-02
申请号：KR1020070140445
申请日：2007-12-28
Applicant: 서강대학교산학협력단
CPC classification number: G01Q60/14 , G01N33/54346 , G01N33/5438 , G01N33/553 , G01N33/585
Abstract: A method for electrically detecting the interaction between bio molecular using a scanning tunneling microscope is provided to analysis nano-sized array and to detect a plurality of analyzing object with one measuring system. A method for electrically detecting the interaction between bio molecular comprises: a step of fixating a first bio molecular on a metallic board; a step of inducing interaction between a second bio molecular and the first bio molecular by applying the second bio molecular on the metallic board; and a step of determining the bond between the first and second bio molecular according to an electric signal measured after the metallic board is scanned by a STM(Scanning Tunneling Microscope). The first bio molecular and the second bio molecular are DNA, RNA, and protein or carbohydrate. The metallic board is a gold substrate.
Abstract translation: 提供了使用扫描隧道显微镜电学检测生物分子之间的相互作用的方法来分析纳米尺寸阵列并且利用一个测量系统检测多个分析对象。 用于电检测生物分子之间的相互作用的方法包括：将第一生物分子固定在金属板上的步骤; 通过在金属板上施加第二生物分子来诱导第二生物分子与第一生物分子之间的相互作用的步骤; 以及根据在通过STM（扫描隧道显微镜）扫描金属板之后测量的电信号来确定第一和第二生物分子之间的键的步骤。 第一个生物分子和第二个生物分子是DNA，RNA和蛋白质或碳水化合物。 金属板是金基板。
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公开(公告)号：KR101613020B1
公开(公告)日：2016-04-18
申请号：KR1020140141430
申请日：2014-10-20
Applicant: 서강대학교산학협력단
IPC: G01N33/53 , C12N15/115 , C12Q1/68
CPC classification number: G01N33/53 , C12N15/115 , C12Q1/68 , G01N33/54326
Abstract: 본발명은 F와특이적으로결합하는앱타머와 RT-PCR 기술을사용하여고감도로표적물질을감지할수 있는표적항원검출용복합체및 이의제조방법에관한것이다. 본발명의표적항원검출용복합체는나노입자와항체를연결하는앱타머를구비하는데, 이러한앱타머는항체의 Fc부분과선택적으로결합하므로항체의활성영역(Fab)을노출시켜표적항원과의반응율을높이며, 또한, RT-PCR로기하급수적으로증폭되므로고감도로표적물질을검출할수 있다.
Abstract translation: 本发明涉及用于检测靶抗原的复合物及其制造方法。 用于检测靶抗原的复合物能够通过使用RT-PCR技术和与Fc特异性结合的适体而具有高灵敏度的靶材料。 用于检测本发明的靶抗原的复合物配备有用于将纳米颗粒连接到抗体的适体。 将适体选择性地结合到抗体的Fc部分，并通过暴露抗体的活性区（Fab）来增加与靶抗原的反应速率。 另外，通过用RT-PCR进行几何放大可以高灵敏度地检测靶物质。
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