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公开(公告)号：KR102137710B1
公开(公告)日：2020-07-28
申请号：KR1020180107960
申请日：2018-09-10
Applicant: 서울대학교산학협력단 , 고려대학교 산학협력단
IPC: C12Q1/6886
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公开(公告)号：KR1020110121492A
公开(公告)日：2011-11-07
申请号：KR1020100041102
申请日：2010-04-30
Applicant: 서울대학교산학협력단
IPC: A01N1/02 , C12N5/0735 , C12N5/07
CPC classification number: A01N1/0221 , C12N5/0657
Abstract: PURPOSE: A composition containing ROCK(Rho-associated kinase) inhibitors for cryopreservation of cardiac myocytes from human embryonic stem cells is provided to develop a cell therapeutic agent. CONSTITUTION: A composition for cryopreservation of cardiac myocytes differentiated from human embryonic stem cells contains ROCK(Rho-associated kinase) inhibitor. The human stem cells are human embryonic stem cells, human embryonic stem cell-derived embryoid body, or human pluripotent stem cells. The ROCK inhibitor is Y-27632, HA-1077, Y-39983, or Wf-536. A method for cryopreservation of differentiated cardiac myocytes comprise: a step of treating the composition to the differentiated cardiac myocytes for 0.25-5 hours; and a step of freezing.
Abstract translation: 目的：提供一种含有ROCK（Rho相关激酶）抑制剂的组合物，用于从人胚胎干细胞中冷冻保存心肌细胞，以开发细胞治疗剂。 构成：用于从人胚胎干细胞分化的心肌细胞的低温保存组合物含有ROCK（Rho-相关激酶）抑制剂。 人类干细胞是人类胚胎干细胞，人类胚胎干细胞衍生的胚状体，或人类多能干细胞。 ROCK抑制剂是Y-27632，HA-1077，Y-39983或Wf-536。 用于分化心肌细胞的低温保存方法包括：将组合物处理至分化心肌细胞0.25-5小时的步骤; 并冻结一步。
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Patent Agency Ranking
公开(公告)号：KR1020110088260A
公开(公告)日：2011-08-03
申请号：KR1020100008085
申请日：2010-01-28
Applicant: 서울대학교산학협력단
IPC: C12N5/077 , C12N5/0735 , C12N5/02
Abstract: PURPOSE: A method for inducing differentiation of human embryonic stem cells to cardiac myocytes is provided. CONSTITUTION: A method for inducing differentiation of human embryonic stem cells to cardiac myocytes comprises: a step of culturing the embryonic stem cells in a medium containing activin A for one day after differentiation; and a step of culturing the embryonic stem cells in a serum-free medium containing BMP2 for 1-5 days. The culture is performed by direct differentiation without formation of embryo bud. The concentrate of activin A is 50-100 ng/ml.
Abstract translation: 目的：提供一种诱导人胚胎干细胞分化为心肌细胞的方法。 构成：诱导人胚胎干细胞向心肌细胞分化的方法包括：在分化后一天培养含有激活素A的培养基中的胚胎干细胞的步骤; 以及在含有BMP2的无血清培养基中培养胚胎干细胞1-5天的步骤。 培养通过直接分化而不形成胚芽进行。 活化素A的浓缩物为50-100ng / ml。
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公开(公告)号：KR101802090B1
公开(公告)日：2017-11-27
申请号：KR1020160123350
申请日：2016-09-26
Applicant: 서울대학교산학협력단
Inventor： 구승엽
IPC: A61K35/48 , A61K31/728
CPC classification number: A61K31/728 , A61K35/48
Abstract: 본발명은탈락막자궁내막세포를포함하는자궁내막손상의치료용조성물에관한것으로, 구체적으로탈락막자궁내막세포및 히알루론산을포함하는자궁내막손상의치료용약학적조성물, 및이를이용한자궁내막손상의치료방법에관한것이다. 본발명의탈락막자궁내막세포및 히알루론산을포함하는조성물은자궁이손상된개체에투여되어손상된자궁을재생시키고, 나아가착상률및 착상된배아발달을개선시킬수 있는바, 자궁내막손상의치료용조성물로유용하게이용될수 있다.
Abstract translation: 本发明中，治疗性物质子宫内膜损伤的化学成分，包括专门消除子宫内膜细胞，并通过透明质酸膜，并使用相同的子宫内膜损伤涉及一种组合物用于子宫内膜损伤的包含子宫内膜细胞蜕膜治疗 本发明涉及的治疗。 包括子宫内膜细胞，并且本发明的透明质酸膜的消除组合物是用于子宫给药的治疗组合物是损坏的对象和播放受损子宫，进一步注入和概念棒可改善胚胎发育和子宫内膜损伤 可以有用地使用。
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公开(公告)号：KR101788968B1
公开(公告)日：2017-10-23
申请号：KR1020160045642
申请日：2016-04-14
Applicant: 서울대학교산학협력단
IPC: C12N5/071
Abstract: 본발명은안지오텐신Ⅱ 수용체작용제를이용한복수난포배양방법에관한것으로, 구체적으로, 분리된복수난포더미를배지에서배양하는제1배양단계및 상기배양단계에서배양된복수난포더미를안지오텐신Ⅱ 수용체작용제를포함하는배지에서배양하는제2배양단계를포함하는난포배양방법, 및안지오텐신Ⅱ 수용체작용제를포함하는복수난포더미배양용조성물에관한것이다. 본발명의복수난포더미배양방법을이용하면, 복수의난포배양이가능하여난자를대량으로생산할수 있으므로, 이로부터수득된난자는체외수정및 불임연구등에유용하게이용될수 있을것이다.
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公开(公告)号：KR101213279B1
公开(公告)日：2012-12-18
申请号：KR1020100041102
申请日：2010-04-30
Applicant: 서울대학교산학협력단
IPC: A01N1/02 , C12N5/0735 , C12N5/07
Abstract: 본발명은인간배아줄기세포로부터분화유도된심근세포동결보존용조성물에관한것으로, 구체적으로 ROCK(Rho-associated kinase 억제제) 억제제를포함하는, 인간배아줄기세포로부터분화유도된심근세포의동결보존용조성물, 인간배아줄기세포로부터유도된심근세포에상기조성물을처리하는단계를포함하는, 분화유도된심근세포를동결보존시키는방법에관한것이다.
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