公开(公告)号：KR101243696B1

公开(公告)日：2013-03-15

申请号：KR1020120054269

申请日：2012-05-22

Applicant: 서울대학교산학협력단 ,  세종대학교산학협력단 ,  한국생명공학연구원

Inventor： 최상호 ,  김병식 ,  김원빈 ,  임동렬 ,  김명희

IPC: A61K31/41 ,  A61K31/4155 ,  A61K31/381 ,  A61K31/18

CPC classification number: A61K31/4155 ,  A23K20/137 ,  A23L29/035 ,  A23L29/045 ,  A23L29/055

Abstract: PURPOSE: A quorum sensing inhibitor and an antibacterial composition using the same are provided to suppress quorum sensing between bacteria, and to prevent or treat infection or diseases. CONSTITUTION: An antibacterial composition using a quorum sensing inhibitor against a pathogenic microorganism contains 1-(5-bromothiophene-2-sulfonyl)-1H pyrazole of chemical formula 1 as an active ingredient. The antibacterial composition is a pharmaceutical composition, a feed composition, a food composition, and a food additive composition.

Abstract translation: 目的：提供一种群体感应抑制剂和使用其的抗菌组合物，以抑制细菌之间的群体感应，并预防或治疗感染或疾病。 构成：使用针对致病微生物的群体感应抑制剂的抗菌组合物含有化学式1的1-（5-溴噻吩-2-磺酰基）-1H-吡唑作为活性成分。 抗菌组合物是药物组合物，饲料组合物，食品组合物和食品添加剂组合物。

公开(公告)号：KR102171321B1

公开(公告)日：2020-10-28

申请号：KR1020180139927

申请日：2018-11-14

Applicant: 서울대학교산학협력단

Inventor： 최상호 ,  정낙신 ,  한호재 ,  하남출 ,  김병식 ,  장경구 ,  이지원

IPC: A61K31/381 ,  A23L33/10 ,  A61P31/00

公开(公告)号：KR101658050B1

公开(公告)日：2016-09-21

申请号：KR1020140076763

申请日：2014-06-23

Applicant: 서울대학교산학협력단 ,  한국생명공학연구원

Inventor： 최상호 ,  김병식 ,  김명희 ,  황중원

IPC: C07K1/02 ,  C07K14/28 ,  C12N15/09 ,  C12N15/31 ,  G01N33/68

CPC classification number: G01N33/56911 ,  C07K14/28 ,  G01N2400/00 ,  G01N2500/04

Abstract: 본발명은비브리오패혈증균의핵심병원성조절단백질인 NanR과 NanR 조절물질인 ManNA6P 결합체의결정화를통해발굴한결합체의입체구조에관한것이다. 또한, NanR 변형단백질, 이를코딩하는폴리뉴클레오티드, 이를포함하는벡터, 및상기벡터를포함한형질전환체에관한것이다. 아울러, 상기결합체의 3차입체구조를설계하여 NanR과 NanR이조절하는유전자들의클러스터인 nan 오페론의전사조절부위 DNA 간의결합을조절하는물질또는 NanR과 ManNAc-6P 간의결합을조절하는물질을스크리닝하는방법및 상기스크리닝된물질을포함하는항균용조성물에관한것이다.

公开(公告)号：KR1020150000436A

公开(公告)日：2015-01-02

申请号：KR1020140076763

申请日：2014-06-23

Applicant: 서울대학교산학협력단 ,  한국생명공학연구원

Inventor： 최상호 ,  김병식 ,  김명희 ,  황중원

IPC: C07K1/02 ,  C07K14/28 ,  C12N15/09 ,  C12N15/31 ,  G01N33/68

CPC classification number: G01N33/56911 ,  C07K14/28 ,  G01N2400/00 ,  G01N2500/04 ,  C07K1/02 ,  A61K38/16 ,  A61K38/17 ,  G01N33/68

Abstract: The present invention relates to stereostructure of a complex found through crystallization of NanR which is a core pathogenic regulatory protein of vibrio vulnificus sepsis and a ManNA6P complex which is a regulatory material of NanR. Also, the present invention relates to a NanR modified protein, polynucleotide coding the same, a vector including the same, and a transformant including the vector. Additionally, the present invention relates to a method for screening a material regulating combination between transcriptional regulatory part DNAs of NanR and nan operon which is a cluster of genes which NanR controls by designing three dimensional stereostructure of the complex, or a material regulating combination between NanR and ManNAc-6P, and to an antibacterial composition including the screened material.

Abstract translation: 本发明涉及通过作为创伤弧菌败血症的核心病原性调节蛋白NanR的结晶发现的复合物的立体结构和作为NanR调节材料的ManNA6P复合物。 此外，本发明涉及NanR修饰蛋白，编码它的多核苷酸，包含该多核苷酸的载体和包含该载体的转化体。 另外，本发明涉及一种筛选NanR转录调节部分DNA与Nan操纵子之间材料调节组合的方法，Nanon是通过设计复合物的三维立体结构NanR控制的基因簇，或NanR 和ManNAc-6P，以及包含筛选材料的抗菌组合物。