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Patent Agency Ranking
公开(公告)号：KR101249635B1
公开(公告)日：2013-04-01
申请号：KR1020100100041
申请日：2010-10-13
Applicant: 서울대학교산학협력단
Abstract: 본 발명은 SNP를 포함하는 양극성 장애 진단용 폴리뉴클레오타이드와 이를 이용한 마이크로어레이 및 키트에 관한 것이다. 또한, 본 발명은 SNP를 이용한 양극성 장애 진단방법에 관한 것이다. 본 발명의 SNP를 이용한 진단방법은 양극성 장애의 발병 및 그 확률을 조기에 진단하여 양극성 장애 치료에 필요한 최적의 치료를 제공할 수 있으며, 유전자 지문 분석과 같은 양극성 장애와 관련된 용도로 사용할 수 있다. 또한, 본 발명의 양극성 장애와 관련된 SNP를 분석하면 양극성 장애의 위험도에 대한 기초적 정보를 제공할 수 있다.
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公开(公告)号：KR101148755B1
公开(公告)日：2012-05-22
申请号：KR1020090126110
申请日：2009-12-17
Applicant: 서울대학교산학협력단
Abstract: PURPOSE: A SNP(single nucleotide polymorphism) of DUSP6 gene related to bipolar disorder is provided to screen a therapeutic agent for bipolar disorder. CONSTITUTION: A SNP(single nucleotide polymorphism) is a polynucleotide having 10 or more serial DNA sequence derived from DNA sequence of sequence number 1 containing 1524th base which is G; and a polynucleotide having 10 or more serial DNA sequence derived from the DNA sequence of sequence number 1 containing 2683th base which is C; or a complementary polynucleotide thereof. A probe for diagnosing bipolar disorder contains the polynucleotide. A microarray for diagnosing bipolar disorder contains the probe. A kit for diagnosing bipolar disorder contains the polynuelcotide. A method for diagnosing bipolar disorder comprises: a step of preparing a nucleic acid sample from a test sample; and a step of determining nucleotide sequence of SNP.
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公开(公告)号：KR1020140078384A
公开(公告)日：2014-06-25
申请号：KR1020120147677
申请日：2012-12-17
Applicant: 서울대학교산학협력단
IPC: A61K31/4515 , A61P35/00
CPC classification number: A61K31/4515 , A23L33/10 , A23V2002/00 , A23V2200/308
Abstract: The present invention relates to a pharmaceutical anti-cancer composition comprising haloperidol as an active ingredient, and provides a composition for treating or preventing cancer using haloperidol. Further, functional health food comprising the haloperidol is provided. The haloperidol according to the present invention facilitates the demethylation of DUSP6 genes and has anti-cancer effects by promoting the transcription of the DUSP6 genes. Reliability of the haloperidol is ensured since the haloperidol has been used as antipsychotic drugs for a long time, thereby the haloperidol can be easily developed as a cancer medicine.
Abstract translation: 本发明涉及包含氟哌啶醇作为活性成分的药物抗癌组合物，并提供使用氟哌啶醇治疗或预防癌症的组合物。 此外，提供了包含氟哌啶醇的功能保健食品。 根据本发明的氟哌啶醇促进DUSP6基因的去甲基化，并通过促进DUSP6基因的转录而具有抗癌作用。 氟哌啶醇的可靠性得到确保，因为氟哌啶醇已被长时间用作抗精神病药物，因此氟哌啶醇可以容易地作为癌症药物开发。
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公开(公告)号：KR1020120038333A
公开(公告)日：2012-04-23
申请号：KR1020100100041
申请日：2010-10-13
Applicant: 서울대학교산학협력단
CPC classification number: C12Q1/6883 , C12Q1/6837 , C12Q2600/156
Abstract: PURPOSE: A polynucleotide for diagnosing bipolar disorders containing SNP is provided to early diagnose and to enable optimal treatment of the bipolar disorders. CONSTITUTION: A polynucleotide for diagnosing bipolar disorders contains or complementary polynucleotide thereof contains 10 or more serial bases having each 11th SNP in a polynucleotide of sequence number 1, 2, 3, or 4. A microarray for diagnosing bipolar disorders contains the polynucleotide, a polypeptide encoded by the polynucleotide, or cDNA thereof. A method for diagnosing the bipolar disorders comprises: a step of isolating nucleic acid sample containing a part of EGR2 gene from a test sample; and a step of determining the 11th base.
Abstract translation: 目的：提供用于诊断含有SNP的双相性精神障碍的多核苷酸，用于早期诊断并能够对双相性精神障碍进行最佳治疗。 构成：用于诊断双相性精神障碍的多核苷酸含有或互补的多核苷酸含有10个或更多个序列号1,2,3或4的多核苷酸中具有第11个SNP的连续碱基。用于诊断双相性精神障碍的微阵列含有多核苷酸，多肽 由多核苷酸编码，或其cDNA。 用于诊断双相性精神障碍的方法包括：从测试样品中分离含有一部分EGR2基因的核酸样品的步骤; 并确定第十一个基地的一个步骤。
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公开(公告)号：KR1020110069395A
公开(公告)日：2011-06-23
申请号：KR1020090126110
申请日：2009-12-17
Applicant: 서울대학교산학협력단
CPC classification number: C12Q1/6827 , C12Q1/6837
Abstract: PURPOSE: A SNP(single nucleotide polymorphism) of DUSP6 gene related to bipolar disorder is provided to screen a therapeutic agent for bipolar disorder. CONSTITUTION: A SNP(single nucleotide polymorphism) is a polynucleotide having 10 or more serial DNA sequence derived from DNA sequence of sequence number 1 containing 1524th base which is G; and a polynucleotide having 10 or more serial DNA sequence derived from the DNA sequence of sequence number 1 containing 2683th base which is C; or a complementary polynucleotide thereof. A probe for diagnosing bipolar disorder contains the polynucleotide. A microarray for diagnosing bipolar disorder contains the probe. A kit for diagnosing bipolar disorder contains the polynuelcotide. A method for diagnosing bipolar disorder comprises: a step of preparing a nucleic acid sample from a test sample; and a step of determining nucleotide sequence of SNP.
Abstract translation: 目的：提供与双相障碍相关的DUSP6基因的SNP（单核苷酸多态性）筛选双相型精神障碍的治疗剂。 构成：SNP（单核苷酸多态性）是具有来源于序列号1的DNA序列的10个以上的连续DNA序列的多核苷酸，其含有第1524位碱基，为G; 以及衍生自序列号1的DNA序列的10个以上的连续DNA序列的多核苷酸，其含有第2683位碱基，为C; 或其互补多核苷酸。 用于诊断双相障碍的探针含有多核苷酸。 用于诊断双相障碍的微阵列包含探针。 用于诊断双相障碍的试剂盒含有多核苷酸。 诊断双相障碍的方法包括：从测试样品制备核酸样品的步骤; 以及确定SNP的核苷酸序列的步骤。
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