公开(公告)号：KR1020110069395A

公开(公告)日：2011-06-23

申请号：KR1020090126110

申请日：2009-12-17

Applicant: 서울대학교산학협력단

Inventor： 김용식 ,  안용민 ,  이규영 ,  김세현

IPC: C12N15/11 ,  C12Q1/68

CPC classification number: C12Q1/6827 ,  C12Q1/6837

Abstract: PURPOSE: A SNP(single nucleotide polymorphism) of DUSP6 gene related to bipolar disorder is provided to screen a therapeutic agent for bipolar disorder. CONSTITUTION: A SNP(single nucleotide polymorphism) is a polynucleotide having 10 or more serial DNA sequence derived from DNA sequence of sequence number 1 containing 1524th base which is G; and a polynucleotide having 10 or more serial DNA sequence derived from the DNA sequence of sequence number 1 containing 2683th base which is C; or a complementary polynucleotide thereof. A probe for diagnosing bipolar disorder contains the polynucleotide. A microarray for diagnosing bipolar disorder contains the probe. A kit for diagnosing bipolar disorder contains the polynuelcotide. A method for diagnosing bipolar disorder comprises: a step of preparing a nucleic acid sample from a test sample; and a step of determining nucleotide sequence of SNP.

Abstract translation: 目的：提供与双相障碍相关的DUSP6基因的SNP（单核苷酸多态性）筛选双相型精神障碍的治疗剂。 构成：SNP（单核苷酸多态性）是具有来源于序列号1的DNA序列的10个以上的连续DNA序列的多核苷酸，其含有第1524位碱基，为G; 以及衍生自序列号1的DNA序列的10个以上的连续DNA序列的多核苷酸，其含有第2683位碱基，为C; 或其互补多核苷酸。 用于诊断双相障碍的探针含有多核苷酸。 用于诊断双相障碍的微阵列包含探针。 用于诊断双相障碍的试剂盒含有多核苷酸。 诊断双相障碍的方法包括：从测试样品制备核酸样品的步骤; 以及确定SNP的核苷酸序列的步骤。

公开(公告)号：KR101148755B1

公开(公告)日：2012-05-22

申请号：KR1020090126110

申请日：2009-12-17

Applicant: 서울대학교산학협력단

Inventor： 김용식 ,  안용민 ,  이규영 ,  김세현

IPC: C12N15/11 ,  C12Q1/68

Abstract: PURPOSE: A SNP(single nucleotide polymorphism) of DUSP6 gene related to bipolar disorder is provided to screen a therapeutic agent for bipolar disorder. CONSTITUTION: A SNP(single nucleotide polymorphism) is a polynucleotide having 10 or more serial DNA sequence derived from DNA sequence of sequence number 1 containing 1524th base which is G; and a polynucleotide having 10 or more serial DNA sequence derived from the DNA sequence of sequence number 1 containing 2683th base which is C; or a complementary polynucleotide thereof. A probe for diagnosing bipolar disorder contains the polynucleotide. A microarray for diagnosing bipolar disorder contains the probe. A kit for diagnosing bipolar disorder contains the polynuelcotide. A method for diagnosing bipolar disorder comprises: a step of preparing a nucleic acid sample from a test sample; and a step of determining nucleotide sequence of SNP.