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    허혈성 조직 영상을 위한 플루오르―１８ 표지 트리아자노난 유도체 또는 이의 약학적으로 허용가능한 염
    2.
    发明公开
    허혈성 조직 영상을 위한 플루오르―１８ 표지 트리아자노난 유도체 또는 이의 약학적으로 허용가능한 염 有权
    F-18标记的三氮呋喃衍生物或药物组合物可用于高分子组织成像

    公开(公告)号：KR1020120135053A

    公开(公告)日：2012-12-12

    申请号：KR1020120056099

    申请日：2012-05-25

    Applicant: 서울대학교산학협력단

    Inventor： 정재민 ,  라티카호이게바자르 ,  이동수 ,  정준기 ,  이명철

    IPC: C07D403/06 ,  C07D255/02 ,  C07F5/06 ,  A61K51/04

    Abstract: PURPOSE: A fluorine-18 labeled triazanonane derivative for ischemic tissue imaging is provided to stably form a complex and to enable PET(Positron Emission Tomography) for determining stroma, cerebrovascular diseases, cancer, nervous diseases, and coronary artery diseases. CONSTITUTION: A triazanonane derivative is denoted by chemical formula 1. The derivative of chemical formula 1 forms a complex together with metals and fluoride. The metal includes aluminum, gallium, indium, thallium, yttrium, or ruthenium. A radiopharmaceutical product contains the derivative of chemical formula 1 and the complex of metals and fluoride as an active ingredient. A method for preparing the derivative of chemical formula 1 comprises: a step of dissolving NODA compounds of chemical formula 2 and a base in an organic solvent; a step of adding nitroimidazole or nitrotriazole compounds to prepare a compound of chemical formula 3; and a step of dissolving the compound of chemical formula 3 in the organic solvent and performing deprotection. [Reference numerals] (AA) Step 1; (BB) Step 2

    Abstract translation: 目的：提供用于缺血组织成像的氟-18标记的三氮代壬烷衍生物以稳定形成复合物并使PET（正电子发射断层扫描）能够测定基质，脑血管疾病，癌症，神经疾病和冠状动脉疾病。 构成：化学式1表示三氮杂壬烷衍生物。化学式1的衍生物与金属和氟化物一起形成络合物。 金属包括铝，镓，铟，铊，钇或钌。 放射性药物产品含有化学式1的衍生物和金属和氟化物的复合物作为活性成分。 制备化学式1的衍生物的方法包括：将化学式2的NODA化合物和碱溶解在有机溶剂中的步骤; 加入硝基咪唑或硝基三唑化合物制备化学式3的化合物的步骤; 将化学式3的化合物溶解在有机溶剂中并进行脱保护的工序。 （附图标记）（AA）步骤1; （BB）步骤2

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