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    양친성 접착제로 제작된 약물 전달 시스템
    2.
    发明公开
    양친성 접착제로 제작된 약물 전달 시스템 有权
    药物输送系统用AMPHIPHILIC粘合剂制备

    公开(公告)号：KR1020130084200A

    公开(公告)日：2013-07-24

    申请号：KR1020120033523

    申请日：2012-03-30

    Applicant: 서울대학교산학협력단

    Inventor： 조동일 ,  유형정 ,  이상민 ,  안재현 ,  홍석준 ,  박종오 ,  박석호 ,  박성준

    IPC: A61K9/16 ,  A61K9/14 ,  A61K47/30 ,  A61K9/22

    CPC classification number: Y02A50/475 ,  Y02A50/481 ,  A61K47/30 ,  A61K35/74

    Abstract: PURPOSE: A drug delivery system is provided to selectively and easily allow bacteria to adhere onto a specific layer by comprising a hydrophilic biodegradable polymer layer and a hydrophobic biodegradable polymer layer. CONSTITUTION: A drug delivery system comprises a hydrophilic biodegradable polymer layer (100) and a hydrophobic biodegradable polymer layer (111). Bacteria adhere onto the surface of one layer among the biodegradable polymer layers. A drug is contained in the biodegradable polymer layer in which bacteria did not adhere. The hydrophilic biodegradable polymer contains one or more ingredients selected from alginate or a derivative thereof, chitosan or a derivative thereof, hyaluronic acid or a derivative thereof, gelatin, collagen, polyethylene glycol (PEG), and polyvinylpyrrolidone (PVP). The hydrophobic biodegradable polymer contains one or more ingredients selected from poly-caprolactone, L-poly-lactides (LPLA), poly-glycolic acid (PGA), poly-D-lactide (PDLA), poly-lactic acid (PLA), and poly-lactic-co-glycolic acid (PLGA). [Reference numerals] (100) Hydrophobic polymer layer; (110) Amphiphilic adhesive material; (111) Hydrophilic polymer layer containing a drug

    Abstract translation: 目的：提供药物递送系统以选择性且容易地通过包括亲水性可生物降解的聚合物层和疏水的可生物降解的聚合物层使细菌粘附在特定的层上。 构成：药物递送系统包括亲水性可生物降解聚合物层（100）和疏水性可生物降解聚合物层（111）。 细菌粘附在可生物降解的聚合物层中的一层的表面上。 药物包含在细菌不粘附的生物可降解聚合物层中。 亲水性生物可降解聚合物含有选自藻酸盐或其衍生物，壳聚糖或其衍生物，透明质酸或其衍生物，明胶，胶原，聚乙二醇（PEG）和聚乙烯吡咯烷酮（PVP））中的一种或多种成分。 疏水性生物降解性聚合物含有选自聚己内酯，L-聚丙交酯（LPLA），聚乙醇酸（PGA），聚-D-丙交酯（PDLA），聚乳酸（PLA）和 聚乳酸 - 共 - 乙醇酸（PLGA）。 （附图标记）（100）疏水性聚合物层; （110）两亲性粘合剂材料; （111）含有药物的亲水性聚合物层

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