公开(公告)号：KR1020140054536A

公开(公告)日：2014-05-09

申请号：KR1020120120124

申请日：2012-10-29

Applicant: 서울대학교산학협력단

Inventor： 이기원 ,  이형주 ,  강남주 ,  백소희 ,  정성근

IPC: A61K31/352 ,  A61K31/35 ,  A61K31/351 ,  A61P17/00

Abstract: The present invention relates to a pharmaceutical composition comprising quercetagetin as an active ingredient for preventing and treating skin diseases or a food composition for alleviating skin diseases. Since the composition comprises quercetagetin, as an active ingredient, which inhibits phosphorylation of JNK and PI3K signaling proteins by combining with JNK-1 and PI3K which are important signaling proteins for regulating inflammatory responses and shows an effect of suppressing the activity of AP-1 and NF-κB which are indicators of inflammation, the composition has an excellent effect for preventing or treating skin diseases such as skin inflammation and skin cancer.

Abstract translation: 本发明涉及包含槲皮素作为预防和治疗皮肤病的活性成分的药物组合物或用于缓解皮肤病的食品组合物。 由于组合物包含槲皮素作为活性成分，其通过与作为调节炎症反应的重要信号蛋白的JNK-1和PI3K结合来抑制JNK和PI3K信号蛋白的磷酸化，并且显示出抑制AP-1的活性和 作为炎症指标的NF-κB，该组合物对预防或治疗皮肤疾病如皮肤炎症和皮肤癌具有优异的效果。