公开(公告)号：KR101276306B1

公开(公告)日：2013-06-18

申请号：KR1020120087736

申请日：2012-08-10

Applicant: 서울대학교산학협력단

Inventor： 이기원 ,  강남주 ,  김영아 ,  김지혜 ,  임순성

IPC: A61K31/352 ,  A61K31/35 ,  A61K8/49 ,  A61P17/00

Abstract: PURPOSE: A composition containing dehydroglyasperin C, dehydroglyasperin D, or isoangustone A as an active ingredient for skin whitening is provided to suppress tyrosinase activity and melanogenesis, and to ensure excellent skin whitening effect. CONSTITUTION: A cosmetic composition for skin whitening contains dehydroglyasperin C of chemical formula 1 as an active ingredient. The cosmetic composition contains dehydroglyasperin D of chemical formula 2 as an active ingredient. The cosmetic composition for skin whitening contains isoangustone A of chemical formula 3 as an active ingredient. The compounds are derived from Glycyrrhizae radix.

Abstract translation: 目的：提供含有脱氢甘油蛋白C，脱氢甘油三酯D或异黄酮A作为皮肤美白活性成分的组合物，以抑制酪氨酸酶活性和黑素生成，并确保优异的皮肤美白效果。 构成：用于皮肤美白的化妆品组合物含有化学式1的脱氢甘油三酯C作为活性成分。 化妆品组合物含有化学式2的脱氢甘油三酯D作为活性成分。 用于皮肤美白的化妆品组合物含有化学式3的异恶唑酮A作为活性成分。 该化合物衍生自甘草（Glycyrrhizae radix）。

公开(公告)号：KR1020140054536A

公开(公告)日：2014-05-09

申请号：KR1020120120124

申请日：2012-10-29

Applicant: 서울대학교산학협력단

Inventor： 이기원 ,  이형주 ,  강남주 ,  백소희 ,  정성근

IPC: A61K31/352 ,  A61K31/35 ,  A61K31/351 ,  A61P17/00

Abstract: The present invention relates to a pharmaceutical composition comprising quercetagetin as an active ingredient for preventing and treating skin diseases or a food composition for alleviating skin diseases. Since the composition comprises quercetagetin, as an active ingredient, which inhibits phosphorylation of JNK and PI3K signaling proteins by combining with JNK-1 and PI3K which are important signaling proteins for regulating inflammatory responses and shows an effect of suppressing the activity of AP-1 and NF-κB which are indicators of inflammation, the composition has an excellent effect for preventing or treating skin diseases such as skin inflammation and skin cancer.

Abstract translation: 本发明涉及包含槲皮素作为预防和治疗皮肤病的活性成分的药物组合物或用于缓解皮肤病的食品组合物。 由于组合物包含槲皮素作为活性成分，其通过与作为调节炎症反应的重要信号蛋白的JNK-1和PI3K结合来抑制JNK和PI3K信号蛋白的磷酸化，并且显示出抑制AP-1的活性和 作为炎症指标的NF-κB，该组合物对预防或治疗皮肤疾病如皮肤炎症和皮肤癌具有优异的效果。