公开(公告)号：KR100968080B1

公开(公告)日：2010-07-08

申请号：KR1020090071732

申请日：2009-08-04

Applicant: 서울대학교산학협력단

Inventor： 김평일 ,  김병기 ,  주황수 ,  성창민 ,  김은미

IPC: C12N1/20 ,  C07K14/00 ,  C12P21/02 ,  C12R1/44

Abstract: PURPOSE: A Staphylococcus hominis MBBL 2-9 strain is provided to ensure antibacterial activity to bacteria and to prevent gram positive/antibiotics resistant pathogen. CONSTITUTION: An antibacterial peptide hominicin which is isolated from Staphylococcus hominis MBBL 2-9 has an amino acid of sequence number 1. The antibacterial peptide is themal resistant, acid resistant, basic resistant, and non-cytotoxicity. The antibacterial peptide contains DmIle(N1, N1-dimethyl isoleucine), Dhb(dehydrobutyrine), and Dmp(N2, N2-dimethyl-1,2-propanediamine). A medicinal composition for preventing gram positive pathogen or antibiotics resistant pathogen contains the antibacterial peptide as an active ingredient.

Abstract translation: 目的：提供人类葡萄球菌MBBL 2-9菌株，以确保对细菌的抗菌活性，并防止革兰氏阳性/抗生素抗性病原体。 构成：从人类金黄色葡萄球菌MBBL 2-9中分离得到的抗菌肽人参皂苷具有序列号1的氨基酸。抗菌肽具有抗药性，耐酸碱性，无细胞毒性。 抗菌肽含有DmIle（N1，N1-二甲基异亮氨酸），Dhb（脱氢丁内酯）和Dmp（N 2，N 2 - 二甲基-1,2-丙二胺）。 用于预防革兰氏阳性病原体或抗生素抗性病原体的药物组合物含有抗菌肽作为活性成分。