公开(公告)号：KR1020140093901A

公开(公告)日：2014-07-29

申请号：KR1020140006081

申请日：2014-01-17

Applicant: 서울대학교산학협력단

Inventor： 송영욱 ,  강재승 ,  배세연 ,  이왕재

IPC: G01N33/68 ,  G01N33/53 ,  G01N33/50

Abstract: The present invention relates to a biomarker for diagnosing rheumatoid arthritis and the use thereof. The marker of the present invention is specifically increased in patients with rheumatoid arthritis. When antibodies or plasminogen are combined with the marker, production of inflammatory cytokines is stimulated. Accordingly, the condition of patients with rheumatoid arthritis is worsened. When the marker of the present invention is used, accurate diagnosis of rheumatoid arthritis can be performed. Also, a prognosis for patients with rheumatoid arthritis can be accurately assessed. When a screening method of the present invention is used, a medicine for preventing and treating rheumatoid arthritis can be quickly and effectively screened.

Abstract translation: 本发明涉及用于诊断类风湿性关节炎的生物标志物及其用途。 本发明的标记物在患有类风湿性关节炎的患者中特别增加。 当抗体或纤溶酶原与标记物组合时，刺激炎性细胞因子的产生。 因此，类风湿关节炎患者的病情恶化。 当使用本发明的标记物时，可以进行类风湿性关节炎的准确诊断。 此外，可以准确评估类风湿关节炎患者的预后。 当使用本发明的筛选方法时，可以快速有效地筛选用于预防和治疗类风湿性关节炎的药物。

公开(公告)号：KR1020100132181A

公开(公告)日：2010-12-17

申请号：KR1020090050865

申请日：2009-06-09

Applicant: 서울대학교산학협력단

Inventor： 이왕재 ,  염수청

IPC: C12N15/09 ,  C12Q1/68 ,  A01K67/027

CPC classification number: C12N15/09 ,  A01K67/0275 ,  C12Q1/6844

Abstract: PURPOSE: A SLA(swine leukocyte antigen) homozygote pig and primer set and method for SLA typing are provided to use SLA pig line as an experimental animal. CONSTITUTION: A SLA(swine leukocyte antigen) homozygote pig has SLA class I Hp-3.0 and class II Hp-0.3. The SLA homozygote pig is obtained by sib mating. A composition for SLA typing comprises a primer set for SLA typing. The SLA typing is performed by confirming PCR product.

Abstract translation: 目的：提供SLA（猪白细胞抗原）纯合子猪和SLA分型的引物组和方法，以SLA猪线作为实验动物。 构成：SLA（猪白细胞抗原）纯合子猪具有SLA I类Hp-3.0和II类Hp-0.3。 SLA纯合子猪通过同胞交配获得。 用于SLA分型的组合物包括用于SLA分型的引物组。 通过确认PCR产物进行SLA分型。