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1.发明公开ＣＭＢＰ와 설폰아마이드 기를 갖는 아미노에탄올 유도체의 단일 단계 반응으로 ＣＨ２ＣＮ기가 도입된 Ｎ―（３－시아노프로필）설폰아마이드 계열의 유도체의 합성방법 无效N-3-氰基丙磺酰胺衍生物的制备方法在一步反应中使用CMBP将具有磺酰胺基团的氨基胆碱衍生物引入CH 2 CN
公开(公告)号：KR1020110047904A
公开(公告)日：2011-05-09
申请号：KR1020090104706
申请日：2009-10-31
Applicant: 서울대학교산학협력단
IPC: C07D277/64 , C07D277/74
Abstract: PURPOSE: A method for synthesizing CH_2CN group-introduced N-(3-cyanopropyl)sulfonamide derivatives is provided to ensure high reactivity and to easily convert into hydrophilic amine group. CONSTITUTION: A N-(3-cyanopropyl)benzothiazolesulfonamide which is used in synthesizing medical products, amino acids, and diamine derivatives has a structural formula 1. A N-(3-cyanopropyl)sulfonamide derivative is synthesized by reacting CMBP((Cyanomethylene)tri-n-butylphosphorane) with OH functional group of aminoethanol of structural formula 2. The synthesis is performed under the presence of benzene or toluene.
Abstract translation: 目的：提供一种合成CH_2CN基导入的N-（3-氰基丙基）磺酰胺衍生物的方法，以确保高反应性并容易地转化为亲水性胺基。 构成：用于合成医药产品，氨基酸和二胺衍生物的N-（3-氰基丙基）苯并噻唑磺酰胺具有结构式1. N-（3-氰基丙基）磺酰胺衍生物通过使CMBP（（氰基亚甲基） 三正丁基磷烷）与结构式2的氨基乙醇的OH官能团反应。合成在苯或甲苯的存在下进行。
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