公开(公告)号：KR1020120130678A

公开(公告)日：2012-12-03

申请号：KR1020110128903

申请日：2011-12-05

Applicant: 서울대학교산학협력단

Inventor： 이미옥 ,  박형근 ,  김은진 ,  손호영 ,  정효준 ,  홍석창

IPC: C07C335/12 ,  A61K31/17 ,  A61P3/00 ,  A61P29/00

Abstract: PURPOSE: A compound is provided to prevent and treat inflammatory diseases and metabolic disease through various biofunctions, being especially useful for preventing and treating liver ailments by controlling cholesterol homeostasis and suppressing the synthesis of lipids. CONSTITUTION: A compound is indicated in chemical formula 1. In chemical formula 1, R1 is hydrogen or a C1-3 alkyl, each of R2 and R3 is hydrogen, or a C1-3 alkyl, alkoxy, hydroxy, nitro, hydroxy or phenoxy group. R4 is hydrogen, a halogen, or a C1-3 alkyl, alkoxy, nitro, hydroxy, cyano, dimethylamino, methylsulfonylamide, trifluoromethyl, vinyl benzene, phenoxy, benzoxy, aryl or phnylamine group, R5 is hydrogen, halogen, or a C1-3 alkyl, alkoxy, nitro, hydroxy or phenoxy group.

Abstract translation: 目的：提供一种化合物，通过各种生物功能预防和治疗炎症性疾病和代谢疾病，特别适用于通过控制胆固醇体内平衡和抑制脂质合成来预防和治疗肝脏疾病。 化学式为化学式1中，R1为氢或C1-3烷基，R2和R3分别为氢或C1-3烷基，烷氧基，羟基，硝基，羟基或苯氧基 组。 R4是氢，卤素或C1-3烷基，烷氧基，硝基，羟基，氰基，二甲基氨基，甲基磺酰胺，三氟甲基，乙烯基苯，苯氧基，苯氧基，芳基或芳基，R5是氢，卤素或C1- 3烷基，烷氧基，硝基，羟基或苯氧基。

公开(公告)号：KR101450960B1

公开(公告)日：2014-10-22

申请号：KR1020120054540

申请日：2012-05-23

Applicant: 서울대학교산학협력단

Inventor： 이미옥 ,  박형근 ,  김은진 ,  손호영 ,  정효준 ,  홍석창 ,  나태영

IPC: C07C335/12 ,  A61K31/145 ,  A61P3/06 ,  A61P1/16

CPC classification number: C07C335/12

Abstract: 본 발명은 RORα 유전자를 활성화시키는 신규한 화합물 또는 그의 염에 관한 것이다. 구체적으로 본 발명은 thiazolidinedione의 하나인 CGP52608을 선도 물질로 하는 신규한 JC1 화합물 또는 이의 약제학적으로 허용가능한 염을 제공한다. 또한, 본 발명은 유효성분으로 상기 신규한 화합물을 포함하는 지질 축적 억제제를 제공한다. 본 발명은 대사성 질환 또는 염증성 질환 치료에 적용될 수 있을 것으로 기대된다.

公开(公告)号：KR1020120130733A

公开(公告)日：2012-12-03

申请号：KR1020120054540

申请日：2012-05-23

Applicant: 서울대학교산학협력단

Inventor： 이미옥 ,  박형근 ,  김은진 ,  손호영 ,  정효준 ,  홍석창 ,  나태영

IPC: C07C335/12 ,  A61K31/145 ,  A61P3/06 ,  A61P1/16

CPC classification number: C07C335/12

Abstract: PURPOSE: A compound is provided to treat and prevent metabolic diseases and inflammatory diseases through various biofunctions of RORα, being especially useful for preventing and treating liver aliments by controlling cholesterol homeostasis and suppression of lipids. CONSTITUTION: A compound is represented by chemical formula 1. In chemical formula 1, R is hydrogen or a C1-3 alkyl group, R2 is hydrogen, a halogen, a C1-3 alkyl, a C1-3 alkoxy, a nitro group, a hydroxyl group, or a phenoxy group, R3 is hydrogen, a halogen, a C1-3 alkyl group, a C1-3 alkoxy group, a nitro group, a hydroxy group, or a phenoxy group, R4 is hydrogen, a halogen, a C1-3 alkyl group, a C1-3 alkoxy group, a nitro group, a hydroxy group, a cyano group, a dimethylamino group, a methylsulfonylamide group, a trifluoromethyl group, a binylbenzene group, a phenoxy group, a benzoxy group, a aryl group, or a phenylamine group, R5 is hydrogen, a halogen, a C1-3 alkyl group, a C1-3 alkoxy group, a nitro group, a hydroxy group, or aphenoxy group.

Abstract translation: 目的：提供一种化合物，通过RORα的各种生物功能治疗和预防代谢疾病和炎症疾病，特别适用于通过控制胆固醇体内平衡和抑制脂质来预防和治疗肝脏营养。 化学式为化学式1中，R为氢或C 1-3烷基，R 2为氢，卤素，C 1-3烷基，C 1-3烷氧基，硝基， 羟基或苯氧基，R3是氢，卤素，C1-3烷基，C1-3烷氧基，硝基，羟基或苯氧基，R4是氢，卤素， C 1-3烷基，C 1-3烷氧基，硝基，羟基，氰基，二甲基氨基，甲基磺酰胺基，三氟甲基，乙烯基苯基，苯氧基，苯氧基， 芳基或苯胺基，R 5为氢，卤素，C 1-3烷基，C 1-3烷氧基，硝基，羟基或苯氧基。