公开(公告)号：KR1020120065115A

公开(公告)日：2012-06-20

申请号：KR1020100126456

申请日：2010-12-10

Applicant: 서울대학교산학협력단

Inventor： 박형근 ,  주상섭 ,  홍석창 ,  이지혜

IPC: C07C67/343 ,  C07C69/38 ,  B01J31/02

CPC classification number: C07C67/343 ,  B01J31/02 ,  C07C69/38

Abstract: PURPOSE: A manufacturing method of optically pure alpha-dialkyl malonate is provided to manufacture asymmetric malonate having desired substituent through successive dialkylation. CONSTITUTION: A manufacturing method of optically pure alpha-dialkyl malonate which is represented by chemical formula 2 comprises the following steps: mixing a compound which is represented by chemical formula 1 and solvent with alkyl halide R-X under existence of (S,S)-NAS which is represented by chemical formula 4; and cooling the mixture down to -100-10 deg/ Celsius; and adding base to the frozen mixture. In the chemical formula 1 and 2, A and A' can be identical different, and are selected from phenyl radical, cyclohexyl group, and cyclopentyl group. The phenyl radical, cyclohexyl group, and cyclopentyl group can be substituted with a substituent which is selected from alkyl group having 1-10 carbons, phenyl radical, benzyl radical, allyl group, alkoxy radical, halogen, alkylester having 1-10 carbons, phenylester, and benzylester group. B is selected from hydrogen, alkyl group having 1-10 carbons, phenyl radical, allyl group, benzyl radical, and halogen. R is selected from alkyl group having 1-10 carbons, phenyl radical, allyl group, and benzyl radical.

Abstract translation: 目的：提供光学纯的丙二酸二烷基酯的制备方法，以通过连续二烷基化制备具有所需取代基的不对称丙二酸酯。 构成：由化学式2表示的光学纯的α-二烷基丙二酸酯的制造方法包括以下步骤：将由（S，S）-NAS存在的化学式1表示的化合物与溶剂与烷基卤RX混合 其由化学式4表示; 并将混合物冷却至-100-10℃/摄氏度; 并向冷冻混合物中加入碱。 在化学式1和化学式2中，A和A'可以相同，选自苯基，环己基和环戊基。 苯基，环己基和环戊基可以被选自具有1-10个碳的烷基，苯基，苄基，烯丙基，烷氧基，卤素，具有1-10个碳的烷基酯，苯基酯 ，和苄基酯基。 B选自氢，具有1-10个碳的烷基，苯基，烯丙基，苄基和卤素。 R选自具有1-10个碳的烷基，苯基，烯丙基和苄基。

公开(公告)号：KR1020140141904A

公开(公告)日：2014-12-11

申请号：KR1020130063220

申请日：2013-06-03

Applicant: 서울대학교산학협력단

Inventor： 박형근 ,  신종헌 ,  오기봉 ,  이상국 ,  홍석창 ,  하민우 ,  정명기 ,  오형찬 ,  방순호 ,  김철우

IPC: C07C323/25 ,  C07C323/29 ,  A61K31/16 ,  A61P35/00

Abstract: 본 발명은 암세포 성장억제 효능이 있는 하기 화학식의 신규한 화합물 또는 그의 염에 관한 것이다. 구체적으로 본 발명은 사마필린A 를 선도 물질로 하는 신규한 화합물 또는 이의 약제학적으로 허용 가능한 염을 제공한다. 본 발명은 항암 치료에 적용될 수 있을 것으로 기대된다.

Abstract translation: 本发明涉及：具有抑制癌细胞生长的作用的化合物及其化学式表示的化合物或其盐。 更具体地说，本发明提供了一种新型化合物，其中帕马林A是铅物质及其药学上可接受的盐。 新化合物可以预期用于癌症治疗。

公开(公告)号：KR1020120130678A

公开(公告)日：2012-12-03

申请号：KR1020110128903

申请日：2011-12-05

Applicant: 서울대학교산학협력단

Inventor： 이미옥 ,  박형근 ,  김은진 ,  손호영 ,  정효준 ,  홍석창

IPC: C07C335/12 ,  A61K31/17 ,  A61P3/00 ,  A61P29/00

Abstract: PURPOSE: A compound is provided to prevent and treat inflammatory diseases and metabolic disease through various biofunctions, being especially useful for preventing and treating liver ailments by controlling cholesterol homeostasis and suppressing the synthesis of lipids. CONSTITUTION: A compound is indicated in chemical formula 1. In chemical formula 1, R1 is hydrogen or a C1-3 alkyl, each of R2 and R3 is hydrogen, or a C1-3 alkyl, alkoxy, hydroxy, nitro, hydroxy or phenoxy group. R4 is hydrogen, a halogen, or a C1-3 alkyl, alkoxy, nitro, hydroxy, cyano, dimethylamino, methylsulfonylamide, trifluoromethyl, vinyl benzene, phenoxy, benzoxy, aryl or phnylamine group, R5 is hydrogen, halogen, or a C1-3 alkyl, alkoxy, nitro, hydroxy or phenoxy group.

Abstract translation: 目的：提供一种化合物，通过各种生物功能预防和治疗炎症性疾病和代谢疾病，特别适用于通过控制胆固醇体内平衡和抑制脂质合成来预防和治疗肝脏疾病。 化学式为化学式1中，R1为氢或C1-3烷基，R2和R3分别为氢或C1-3烷基，烷氧基，羟基，硝基，羟基或苯氧基 组。 R4是氢，卤素或C1-3烷基，烷氧基，硝基，羟基，氰基，二甲基氨基，甲基磺酰胺，三氟甲基，乙烯基苯，苯氧基，苯氧基，芳基或芳基，R5是氢，卤素或C1- 3烷基，烷氧基，硝基，羟基或苯氧基。

公开(公告)号：KR101450960B1

公开(公告)日：2014-10-22

申请号：KR1020120054540

申请日：2012-05-23

Applicant: 서울대학교산학협력단

Inventor： 이미옥 ,  박형근 ,  김은진 ,  손호영 ,  정효준 ,  홍석창 ,  나태영

IPC: C07C335/12 ,  A61K31/145 ,  A61P3/06 ,  A61P1/16

CPC classification number: C07C335/12

Abstract: 본 발명은 RORα 유전자를 활성화시키는 신규한 화합물 또는 그의 염에 관한 것이다. 구체적으로 본 발명은 thiazolidinedione의 하나인 CGP52608을 선도 물질로 하는 신규한 JC1 화합물 또는 이의 약제학적으로 허용가능한 염을 제공한다. 또한, 본 발명은 유효성분으로 상기 신규한 화합물을 포함하는 지질 축적 억제제를 제공한다. 본 발명은 대사성 질환 또는 염증성 질환 치료에 적용될 수 있을 것으로 기대된다.

公开(公告)号：KR1020120130733A

公开(公告)日：2012-12-03

申请号：KR1020120054540

申请日：2012-05-23

Applicant: 서울대학교산학협력단

Inventor： 이미옥 ,  박형근 ,  김은진 ,  손호영 ,  정효준 ,  홍석창 ,  나태영

IPC: C07C335/12 ,  A61K31/145 ,  A61P3/06 ,  A61P1/16

CPC classification number: C07C335/12

Abstract: PURPOSE: A compound is provided to treat and prevent metabolic diseases and inflammatory diseases through various biofunctions of RORα, being especially useful for preventing and treating liver aliments by controlling cholesterol homeostasis and suppression of lipids. CONSTITUTION: A compound is represented by chemical formula 1. In chemical formula 1, R is hydrogen or a C1-3 alkyl group, R2 is hydrogen, a halogen, a C1-3 alkyl, a C1-3 alkoxy, a nitro group, a hydroxyl group, or a phenoxy group, R3 is hydrogen, a halogen, a C1-3 alkyl group, a C1-3 alkoxy group, a nitro group, a hydroxy group, or a phenoxy group, R4 is hydrogen, a halogen, a C1-3 alkyl group, a C1-3 alkoxy group, a nitro group, a hydroxy group, a cyano group, a dimethylamino group, a methylsulfonylamide group, a trifluoromethyl group, a binylbenzene group, a phenoxy group, a benzoxy group, a aryl group, or a phenylamine group, R5 is hydrogen, a halogen, a C1-3 alkyl group, a C1-3 alkoxy group, a nitro group, a hydroxy group, or aphenoxy group.

Abstract translation: 目的：提供一种化合物，通过RORα的各种生物功能治疗和预防代谢疾病和炎症疾病，特别适用于通过控制胆固醇体内平衡和抑制脂质来预防和治疗肝脏营养。 化学式为化学式1中，R为氢或C 1-3烷基，R 2为氢，卤素，C 1-3烷基，C 1-3烷氧基，硝基， 羟基或苯氧基，R3是氢，卤素，C1-3烷基，C1-3烷氧基，硝基，羟基或苯氧基，R4是氢，卤素， C 1-3烷基，C 1-3烷氧基，硝基，羟基，氰基，二甲基氨基，甲基磺酰胺基，三氟甲基，乙烯基苯基，苯氧基，苯氧基， 芳基或苯胺基，R 5为氢，卤素，C 1-3烷基，C 1-3烷氧基，硝基，羟基或苯氧基。