公开(公告)号：KR1020090014428A

公开(公告)日：2009-02-11

申请号：KR1020070077882

申请日：2007-08-02

Applicant: 성균관대학교산학협력단

Inventor： 홍성렬 ,  권무식 ,  이충은 ,  조재열 ,  김서영

IPC: A61K38/08 ,  A61P35/00

CPC classification number: A61K38/12 ,  A61K9/0019 ,  A61K9/0053 ,  A61K9/08 ,  A61K9/10 ,  A61K9/14 ,  A61K9/20 ,  A61K9/48 ,  A61K2039/585

Abstract: An anti-cancer composition comprising surfactin is provided to inhibit the cell proliferation, and the proliferation of the human colon carcinoma cell by inducing pro-apoptotic activity and suppressing the differentiation and proliferation of LoVo cell by inhibiting cell cycle. The composition for treating cancer comprises surfactin and further comprises the pharmaceutically acceptable carrier selected from diluent, lubricant, binder, disintegrant, sweetener, stabilizer and antiseptic, and additive selected from perfume and vitamin B.

Abstract translation: 提供包含表面活化素的抗癌组合物，通过诱导促凋亡活性并通过抑制细胞周期抑制LoVo细胞的分化和增殖来抑制细胞增殖和人结肠癌细胞的增殖。 用于治疗癌症的组合物包括表面活性素，并且还包含选自稀释剂，润滑剂，粘合剂，崩解剂，甜味剂，稳定剂和防腐剂的药学上可接受的载体，以及选自香料和维生素B的添加剂。