公开(公告)号：KR100882194B1

公开(公告)日：2009-02-06

申请号：KR1020070137246

申请日：2007-12-26

Applicant: 성균관대학교산학협력단

Inventor： 이강노 ,  정칠만 ,  권학철 ,  이강춘 ,  손미원

IPC: C07C62/04 ,  C07C59/48

Abstract: 본 발명은 항고지혈(抗高脂血), 항산화(抗酸化) 및 항바이러스 활성을 갖는 참취(
Aster

scaber ) 추출물; 상기 추출물로부터 분리된 신규 화합물인 (3S)-3,7-디메틸-옥타-1,5-디엔-7-하이드로페록시-3-Ο-(3
' ,4
' -디안젤로일)-β-D-글로코피라노시드[(3S)-3,7-dimethyl-octa-1,5-diene-7-hydroperoxy-3-O-(3
' ,4
' -diangeloyl)-β-D-glucopyranoside], (3
S )-3,7-디메틸-옥타-1,7-디엔-6-하이드로페록시-3-
O - (3
' ,4
' -디안젤로일)-β-D-글루코피라노시드[(3
S )-3,7-dimethyl-octa-1,7-diene-6-hydroperoxy-3-
O -(3
' ,4
' -diangeloyl)-β-D-glucopyranoside], 메틸-3,5-디카페오일
-뮤코-퀴닉산(methyl-3,5-dicaffeoyl-
muco -quinic acid), (-) 3,5-디카페오일-뮤코-퀴닉산[(-) 3,5-dicaffeoyl-
muco -quinic acid], (-) 4-카페오일-뮤코-퀴닉산[(-) 4-caffeoyl-muco-quinic acid], 이들의 제조방법 및 이들의 항고지혈제, 항산화제 및 항바이러스제로서의 용도; 및 상기 참취 추출물로부터 분리된 α-스피나스테롤(α-spinasterol), 게르마크라트리엔 1-올(germacratriene 1-ol), 7δ-메톡시-4(14)-오포지텐-1-올[7δ-methoxy-4(14)-oppositen-1-ol], 7δ-메톡시-4(15)-유데스만-1-올[7δ-methoxy-4(15)-eudesmann-1-ol], α-스피나스테롤-3-Ο-β-D-글루코피라노오스(α-spinasterol-3-O-β-D-glucopyranose), 3,5-디카페오일 퀴닉산(3,5-dicaffeoyl quinic acid), 4,5-디카페오일퀴닉산(4,5-dicaffeoyl quinic acid), 5-카페오일퀴닉산(클로로제닉산)[5-caffeoylquinic acid (chlorogenic acid)]의 항고지혈제, 항산화제 및 항바이러스제로서의 용도에 관한 것이다.
참취(Aster scaber), 고지혈(抗高脂血), 항산화(抗酸化), 항바이러스

公开(公告)号：KR1020020013237A

公开(公告)日：2002-02-20

申请号：KR1020000046816

申请日：2000-08-12

Applicant: 성균관대학교산학협력단

Inventor： 이강노 ,  정칠만 ,  권학철 ,  이강춘 ,  손미원

IPC: A61K36/28 ,  A61P3/06 ,  A61P31/12 ,  A61P31/18

Abstract: PURPOSE: Provided are Aster scaber extract having anti-hyperlipemia, anti-oxidation and anti-virus activities and a novel compound separated therefrom. They are useful in manufacturing remedial compositions and food compositions which are used for the prevention and treatment of cardiovascular diseases caused by hyperlipemia and various diseases caused by oxidative stress. CONSTITUTION: The extract of Aster scaber is obtained by extracting Aster scaber with lower alcohol then drying the extract; and suspending the extract in water then adding an organic solvent thereto. The organic solvent is selected from the group consisting of methylene chloride, butanol, ethylacetate or their mixture. The novel compounds separated therefrom are as follows: (3S)-3,7-dimethyl-octa-1,5-diene-7-hydroperoxy-3-O-(3',4'-diangeloyl)-beta-D-glucopyranoside of the formula(1), (3S)-3,7-dimethyl-octa-1,7-diene-6-hydroperoxy-3-O-(3',4'-diangeloyl)-beta-D-glucopyranoside of the formula(2), methyl-3,5-dicaffeoyl-muco-quinic acid of the formula(3), (-) 3,5-dicaffeoyl-muco-quinic acid of the formula(4), and (-) 4-caffeoyl-muco-quinic acid of the formula(5).

Abstract translation: 目的：提供具有抗高脂血症，抗氧化和抗病毒活性的Aster scaber提取物和与其分离的新化合物。 它们可用于制造用于预防和治疗由高脂血症引起的心血管疾病和由氧化应激引起的各种疾病的补救组合物和食物组合物。 构成：通过用低级醇提取Aster scaber然后干燥提取物获得Aster scaber的提取物; 并将提取物悬浮在水中，然后向其中加入有机溶剂。 有机溶剂选自二氯甲烷，丁醇，乙酸乙酯或它们的混合物。 从其分离的新化合物如下：（3S）-3,7-二甲基 - 八氢-1,5-二烯-7-氢过氧-3-O-（3'，4'-二月桂酰基）-β-D-吡喃葡萄糖苷 的式（1），（3S）-3,7-二甲基 - 辛-1,7-二烯-6-氢过氧-3-O-（3'，4'-二月桂酰基）-β-D-吡喃葡萄糖苷 式（3）的（甲基-3,5-二脱氧尿基 - 粘 - 奎尼酸），式（4）的（ - ）3,5-二咖啡酰 - 粘 - 奎尼酸和（ - ）4- 式（5）的咖啡酰 - 粘 - 奎酸。

公开(公告)号：KR1020080015769A

公开(公告)日：2008-02-20

申请号：KR1020070137246

申请日：2007-12-26

Applicant: 성균관대학교산학협력단

Inventor： 이강노 ,  정칠만 ,  권학철 ,  이강춘 ,  손미원

IPC: C07C62/04 ,  C07C59/48

Abstract: A compound isolated from Aster scaber extracts is provided to ensure excellent hypocholesterolemic, antioxidative, and antiviral actions and be useful for preventing or treating cardiovascular diseases caused by hyperlipidemia and various diseases caused by oxidative stress. A compound isolated from Aster scaber extracts has a structure represented by the following formula 3, 4, or 5. In the formula 3, R is a methyl group, R1 and R3 are caffeoyl groups, and R2 is hydrogen. In the formula 4, R1 and R3 are caffeoyl groups and R2 is hydrogen. In the formula 5, R1 and R3 are hydrogen and R2 is a caffeoyl group. The Aster scaber extracts are obtained by extracting Aster scaber with lower alcohol, and extracting the obtained extract with an organic solvent again. The organic solvent is methanol, methylene chloride, ethylacetate, butanol, or a mixture thereof.

Abstract translation: 提供从Aster scaber提取物分离的化合物，以确保优异的低胆固醇血症，抗氧化和抗病毒作用，并且可用于预防或治疗由高脂血症和由氧化应激引起的各种疾病引起的心血管疾病。 从Aster scaber提取物中分离的化合物具有由下式3,4或5表示的结构。在式3中，R为甲基，R 1和R 3为咖啡酰基，R 2为氢。 在式4中，R1和R3是咖啡酰基，R2是氢。 式5中，R 1和R 3为氢，R 2为咖啡酰基。 通过用低级醇萃取Aster scaber获得Aster scaber提取物，并再次用有机溶剂萃取所得提取物。 有机溶剂是甲醇，二氯甲烷，乙酸乙酯，丁醇或其混合物。

公开(公告)号：KR100831645B1

公开(公告)日：2008-05-22

申请号：KR1020000046816

申请日：2000-08-12

Applicant: 성균관대학교산학협력단

Inventor： 이강노 ,  정칠만 ,  권학철 ,  이강춘 ,  손미원

IPC: A61K36/28 ,  A61P3/06 ,  A61P31/12 ,  A61P31/18

Abstract: 본 발명은 항고지혈(抗高脂血), 항산화(抗酸化) 및 항바이러스 활성을 갖는 참취(
Aster scaber ) 추출물; 상기 추출물로부터 분리된 신규 화합물인 (3S)-3,7-디메틸-옥타-1,5-디엔-7-하이드로페록시-3-Ο-(3
' ,4
' -디안젤로일)-β-D-글로코피라노시드[(3S)-3,7-dimethyl-octa-1,5-diene-7-hydroperoxy-3-O-(3
' ,4
' -diangeloyl)-β-D-glucopyranoside], (3
S )-3,7-디메틸-옥타-1,7-디엔-6-하이드로페록시-3-
O - (3
' ,4
' -디안젤로일)-β-D-글루코피라노시드[(3
S )-3,7-dimethyl-octa-1,7-diene-6-hydroperoxy-3-
O -(3
' ,4
' -diangeloyl)-β-D-glucopyranoside], 메틸-3,5-디카페오일
-뮤코-퀴닉산(methyl-3,5-dicaffeoyl-
muco -quinic acid), (-) 3,5-디카페오일-뮤코-퀴닉산[(-) 3,5-dicaffeoyl-
muco -quinic acid], (-) 4-카페오일-뮤코-퀴닉산[(-) 4-caffeoyl-muco-quinic acid], 이들의 제조방법 및 이들의 항고지혈제, 항산화제 및 항바이러스제로서의 용도; 및 상기 참취 추출물로부터 분리된 α-스피나스테롤(α-spinasterol), 게르마크라트리엔 1-올(germacratriene 1-ol), 7δ-메톡시-4(14)-오포지텐-1-올[7δ-methoxy-4(14)-oppositen-1-ol], 7δ-메톡시-4(15)-유데스만-1-올[7δ-methoxy-4(15)-eudesmann-1-ol], α-스피나스테롤-3-Ο-β-D-글루코피라노오스(α-spinasterol-3-O-β-D-glucopyranose), 3,5-디카페오일 퀴닉산(3,5-dicaffeoyl quinic acid), 4,5-디카페오일퀴닉산(4,5-dicaffeoyl quinic acid), 5-카페오일퀴닉산(클로로제닉산)[5-caffeoylquinic acid (chlorogenic acid)]의 항고지혈제, 항산화제 및 항바이러스제로서의 용도에 관한 것이다.