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    항고지혈, 항산화 및 항바이러스 활성을 갖는 참취 추출물및 그로부터 분리된 화합물
    7.
    发明授权
    항고지혈, 항산화 및 항바이러스 활성을 갖는 참취 추출물및 그로부터 분리된 화합물 失效
    Chamchi Aster刺骨提取物和具有降胆固醇，抗氧化和抗病毒活性的化合物

    公开(公告)号：KR100831645B1

    公开(公告)日：2008-05-22

    申请号：KR1020000046816

    申请日：2000-08-12

    Applicant: 성균관대학교산학협력단

    Inventor： 이강노 ,  정칠만 ,  권학철 ,  이강춘 ,  손미원

    IPC: A61K36/28 ,  A61P3/06 ,  A61P31/12 ,  A61P31/18

    Abstract: 본 발명은 항고지혈(抗高脂血), 항산화(抗酸化) 및 항바이러스 활성을 갖는 참취(
    Aster scaber ) 추출물; 상기 추출물로부터 분리된 신규 화합물인 (3S)-3,7-디메틸-옥타-1,5-디엔-7-하이드로페록시-3-Ο-(3
    ' ,4
    ' -디안젤로일)-β-D-글로코피라노시드[(3S)-3,7-dimethyl-octa-1,5-diene-7-hydroperoxy-3-O-(3
    ' ,4
    ' -diangeloyl)-β-D-glucopyranoside], (3
    S )-3,7-디메틸-옥타-1,7-디엔-6-하이드로페록시-3-
    O - (3
    ' ,4
    ' -디안젤로일)-β-D-글루코피라노시드[(3
    S )-3,7-dimethyl-octa-1,7-diene-6-hydroperoxy-3-
    O -(3
    ' ,4
    ' -diangeloyl)-β-D-glucopyranoside], 메틸-3,5-디카페오일
    -뮤코-퀴닉산(methyl-3,5-dicaffeoyl-
    muco -quinic acid), (-) 3,5-디카페오일-뮤코-퀴닉산[(-) 3,5-dicaffeoyl-
    muco -quinic acid], (-) 4-카페오일-뮤코-퀴닉산[(-) 4-caffeoyl-muco-quinic acid], 이들의 제조방법 및 이들의 항고지혈제, 항산화제 및 항바이러스제로서의 용도; 및 상기 참취 추출물로부터 분리된 α-스피나스테롤(α-spinasterol), 게르마크라트리엔 1-올(germacratriene 1-ol), 7δ-메톡시-4(14)-오포지텐-1-올[7δ-methoxy-4(14)-oppositen-1-ol], 7δ-메톡시-4(15)-유데스만-1-올[7δ-methoxy-4(15)-eudesmann-1-ol], α-스피나스테롤-3-Ο-β-D-글루코피라노오스(α-spinasterol-3-O-β-D-glucopyranose), 3,5-디카페오일 퀴닉산(3,5-dicaffeoyl quinic acid), 4,5-디카페오일퀴닉산(4,5-dicaffeoyl quinic acid), 5-카페오일퀴닉산(클로로제닉산)[5-caffeoylquinic acid (chlorogenic acid)]의 항고지혈제, 항산화제 및 항바이러스제로서의 용도에 관한 것이다.

    백강잠 101Ａ로부터 분리, 정제한 뇌신경성장 촉진물질(4Ｅ, 6Ｅ, 2Ｓ,3Ｒ)-2-Ｎ-도코사노일-4,6-테트라데카스핀가디에닌
    8.
    发明公开
    백강잠 101Ａ로부터 분리, 정제한 뇌신경성장 촉진물질(4Ｅ, 6Ｅ, 2Ｓ,3Ｒ)-2-Ｎ-도코사노일-4,6-테트라데카스핀가디에닌 有权
    （4E，6E，2S，3R）-2-N-DOCOSANOY-4,6-TETRADECASPHINGADIENINE从BEAUVERIA BASSIANA 101A分离和纯化

    公开(公告)号：KR1020040012398A

    公开(公告)日：2004-02-11

    申请号：KR1020020045968

    申请日：2002-08-03

    Applicant: 대한민국(농촌진흥청장) ,  성균관대학교산학협력단

    Inventor： 조세연 ,  정이연 ,  이강노 ,  권학철 ,  김선녀

    IPC: C07C233/05

    Abstract: PURPOSE: Provided is new sphingolipid, (4E, 6E, 2S, 3R)-2-N-Docosanoyl-4,6-tetradecasphingadienine which is isolated and purified from Beauveria bassiana 101A and has prevention and treatment effects on degenerative brain diseases. CONSTITUTION: New sphingolipid, (4E, 6E, 2S, 3R)-2-N-Docosanoyl-4,6-tetradecasphingadienine is isolated and purified from Beauveria bassiana 101A and has prevention and treatment effects on degenerative brain diseases. It is characteristically represented by the formula(1). A pharmaceutical preparation for prevention and treatment of brain diseases characteristically contains (4E, 6E, 2S, 3R)-2-N-Docosanoyl-4,6-tetradecasphingadienine as an active ingredient.

    Abstract translation: 目的：提供从Beauveria bassiana 101A分离纯化的新型鞘脂（4E，6E，2S，3R）-2-N-二十二烷基-4,6-十四碳环糊精，并对退行性脑病具有预防和治疗作用。 构成：新型鞘脂（4E，6E，2S，3R）-2-N-二十二烷基-4,6-十四碳二烯雌酚从白僵菌101A中分离纯化，对退行性脑病具有预防和治疗作用。 它由式（1）表征。 用于预防和治疗脑疾病的药物制剂特征性地含有（4E，6E，2S，3R）-2-N-二十一烷酰基-4,6-十四碳环糊精作为活性成分。

    항고지혈, 항산화 및 항바이러스 활성을 갖는 참취추출물로부터 분리된 화합물
    10.
    发明公开
    항고지혈, 항산화 및 항바이러스 활성을 갖는 참취추출물로부터 분리된 화합물 失效
    与HYPOCHESTEROLEMIC，抗氧化和抗病活性相关的CHAMCHI（ASTER SCABER）提取物分离出的具有高磷脂酰肌醇，抗氧化活性和抗病毒活性的化合物

    公开(公告)号：KR1020080015769A

    公开(公告)日：2008-02-20

    申请号：KR1020070137246

    申请日：2007-12-26

    Applicant: 성균관대학교산학협력단

    Inventor： 이강노 ,  정칠만 ,  권학철 ,  이강춘 ,  손미원

    IPC: C07C62/04 ,  C07C59/48

    Abstract: A compound isolated from Aster scaber extracts is provided to ensure excellent hypocholesterolemic, antioxidative, and antiviral actions and be useful for preventing or treating cardiovascular diseases caused by hyperlipidemia and various diseases caused by oxidative stress. A compound isolated from Aster scaber extracts has a structure represented by the following formula 3, 4, or 5. In the formula 3, R is a methyl group, R1 and R3 are caffeoyl groups, and R2 is hydrogen. In the formula 4, R1 and R3 are caffeoyl groups and R2 is hydrogen. In the formula 5, R1 and R3 are hydrogen and R2 is a caffeoyl group. The Aster scaber extracts are obtained by extracting Aster scaber with lower alcohol, and extracting the obtained extract with an organic solvent again. The organic solvent is methanol, methylene chloride, ethylacetate, butanol, or a mixture thereof.

    Abstract translation: 提供从Aster scaber提取物分离的化合物，以确保优异的低胆固醇血症，抗氧化和抗病毒作用，并且可用于预防或治疗由高脂血症和由氧化应激引起的各种疾病引起的心血管疾病。 从Aster scaber提取物中分离的化合物具有由下式3,4或5表示的结构。在式3中，R为甲基，R 1和R 3为咖啡酰基，R 2为氢。 在式4中，R1和R3是咖啡酰基，R2是氢。 式5中，R 1和R 3为氢，R 2为咖啡酰基。 通过用低级醇萃取Aster scaber获得Aster scaber提取物，并再次用有机溶剂萃取所得提取物。 有机溶剂是甲醇，二氯甲烷，乙酸乙酯，丁醇或其混合物。

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