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公开(公告)号：KR101455901B1
公开(公告)日：2014-11-03
申请号：KR1020120047766
申请日：2012-05-04
Applicant: 성균관대학교산학협력단
IPC: A61K9/08 , A61K47/48 , A61K31/44 , A61K31/404
CPC classification number: A61K47/10 , A61K31/635 , A61K47/40
Abstract: 본 발명은 난용성 약물인 세레콕시브에 폴록사머를 첨가하여 공융 현상을 일으킴으로써, 용해도 및 생체이용률이 현저하게 증가된 세레콕시브를 제공하는 공융 혼합물에 관한 것이다.
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公开(公告)号：KR1020140075662A
公开(公告)日：2014-06-19
申请号：KR1020140063999
申请日：2014-05-27
Applicant: 성균관대학교산학협력단
CPC classification number: A61K47/34 , A61K31/635
Abstract: The present invention relates to a eutectic composition comprising celecoxib and poloxamer. The eutectic composition comprising celecoxib and poloxamer according to one embodiment of the present invention includes celecoxib or pharmaceutically acceptable salt and block copolymer of poly (polyoxyethylene) and poly (Polyoxypropylene) and is manufactured by thermal melting.
Abstract translation: 本发明涉及包含塞来昔布和泊洛沙姆的共晶组合物。 根据本发明一个实施方案的包含塞来昔布和泊洛沙姆的共晶组合物包括塞来昔布或其可药用盐和聚（聚氧乙烯）和聚（聚氧丙烯）的嵌段共聚物，并且通过热熔制造。
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公开(公告)号：KR1020130124113A
公开(公告)日：2013-11-13
申请号：KR1020120047766
申请日：2012-05-04
Applicant: 성균관대학교산학협력단
IPC: A61K9/08 , A61K47/48 , A61K31/44 , A61K31/404
CPC classification number: A61K47/10 , A61K31/635 , A61K47/40 , A61K9/08 , A61K31/404 , A61K31/44 , A61K47/50
Abstract: The present invention relates to an eutectic mixture having celecoxib with remarkably enhanced solubility and bioavailability through an eutetic reaction by adding poloxamer of chemical formula 2 to celecoxib of chemical formula 1 which is an insoluble drug. The weight ratio of poloxamer with respect to celecoxib is 3:7-6:4. More preferably, the eutectic mixture according to the present invention contains 1.5 parts by weight of poloxamer with respect to 1 part by weight of celecoxib. [Reference numerals] (AA) Temperature ;(BB) % celecoxib
Abstract translation: 本发明涉及一种具有塞来昔布的共晶混合物，其通过将化学式2的泊洛沙姆加入作为不溶性药物的化学式1的塞来昔布，通过可口反应显着提高溶解性和生物利用度。 泊洛沙姆相对于塞来昔布的重量比为3：7-6：4。 更优选地，根据本发明的共晶混合物相对于1重量份的塞来昔布含有1.5重量份泊洛沙姆。 （参考号）（AA）温度;（BB）％塞来昔布
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