公开(公告)号：KR1020130009416A

公开(公告)日：2013-01-23

申请号：KR1020110070521

申请日：2011-07-15

Applicant: 성균관대학교산학협력단

Inventor： 박은석 ,  박천웅 ,  안수현 ,  김주영 ,  하정명 ,  이윤석 ,  오택운

IPC: A61K31/428 ,  A61K31/425 ,  A61K9/16 ,  A61K9/22

CPC classification number: A61K31/428 ,  A61K9/16 ,  A61K9/20 ,  A61K47/38

Abstract: PURPOSE: A sustained release microparticle containing pramipexole and ethyl cellulose and an orally fast disintegrating tablet containing the same are provided to maintain effective blood concentration and to improve drug compliance. CONSTITUTION: A sustained release microparticle of pramipexole contains 1 part by weight of pramipexole or a salt thereof and 13-33 parts by weight of ethyl cellulose. The salt is pramipexole hydrochloride. The viscosity of ethyl cellulose is 6-22 cp. An orally fast disintegrating tablet contains the sustained release granules, sugar alcohol, and a disintegrant. The orally fast disintegrating tablet contains 50-55 parts by weight of sugar alcohol based on 100 parts by weight of the sustained release granules. The orally fast disintegrating tablet additionally contains an excipient. [Reference numerals] (AA) Elution rate; (BB) Time(hour); (CC) Embodiment 3-1; (DD) Embodiment 3-2; (EE) Embodiment 3-3; (FF) Embodiment 3-4

Abstract translation: 目的：提供含有普拉克索和乙基纤维素的持续释放微粒和含有它的口服快速崩解片，以保持有效的血液浓度并改善药物依从性。 构成：普拉克索的缓释微粒含有1重量份的普拉克索或其盐和13-33重量份的乙基纤维素。 盐是普拉克索盐酸盐。 乙基纤维素的粘度为6-22厘泊。 口服快速崩解片含有缓释颗粒，糖醇和崩解剂。 口服快速崩解片剂基于100重量份的缓释颗粒含有50-55重量份的糖醇。 口服快速崩解片还含有赋形剂。 （附图标记）（AA）洗脱率; （BB）时间（小时）; （CC）实施例3-1; （DD）实施例3-2; （EE）实施例3-3; （FF）实施例3-4

公开(公告)号：KR1020130037802A

公开(公告)日：2013-04-17

申请号：KR1020110102243

申请日：2011-10-07

Applicant: 성균관대학교산학협력단

Inventor： 박은석 ,  이윤석 ,  김주영 ,  오택운 ,  하정명 ,  안수현

IPC: A61K9/28 ,  A61K31/428 ,  A61K47/38

CPC classification number: A61K9/28 ,  A61K9/2866 ,  A61K31/428 ,  A61K47/38

Abstract: PURPOSE: A sustained release fine particle containing pramipexole and a composition containing the same are provided to ensure a release-controlling effect by additional coating of ethyl cellulose. CONSTITUTION: A composition is a release-controlled formulation which is prepared by coating a sustained release fine particle containing pramipexole or a salt thereof with a coating solution containing ethyl cellulose. The sustained release fine particle contains pramipezole or a salt thereof and hydroxypropyl methylcellulose. [Reference numerals] (AA) Elution rate(%); (BB) Time(h); (CC) Bead weight ratio of before coating : after coating = 1 : 1.5; (DD) Bead weight ratio of before coating : after coating = 1 : 1.3;

Abstract translation: 目的：提供含有普拉克索的缓释微粒和含有它们的组合物，以通过额外涂布乙基纤维素来确保释放控制效果。 构成：组合物是通过用含有乙基纤维素的涂布溶液涂布含有普拉克索或其盐的缓释微粒制备的释放控制制剂。 持续释放的微粒含有丙胺嘧啶或其盐和羟丙基甲基纤维素。 （AA）洗脱率（％） （BB）时间（h）; （CC）涂布前的珠重比：涂布后= 1：1.5; （DD）涂布前的珠重比：涂布后= 1：1.3;

公开(公告)号：KR1020110104374A

公开(公告)日：2011-09-22

申请号：KR1020100023482

申请日：2010-03-16

Applicant: 성균관대학교산학협력단

Inventor： 박은석 ,  박천웅 ,  이윤석 ,  오택운 ,  김주영 ,  안수현

IPC: A61K9/16 ,  A61K9/32 ,  A61K47/36 ,  A61K31/425

CPC classification number: A61K9/1652 ,  A61K9/1658 ,  A61K9/167 ,  A61K9/1682 ,  A61K31/428 ,  Y10S514/97

Abstract: 본 발명은 저장 안정성이 높은 프라미펙솔 디하이드로클로라이드(pramipexole dihydrochloride) 정제 및 이의 제조방법을 제공하기 위한 것이다.