公开(公告)号：KR1020150054728A

公开(公告)日：2015-05-20

申请号：KR1020150056693

申请日：2015-04-22

Applicant: 성균관대학교산학협력단

Inventor： 김경규 ,  이현숙 ,  데보죠티데

IPC: A61K31/55 ,  C12N5/07

Abstract: 본발명은세쿠리닌(securinine)을유효성분으로포함하는암 줄기세포분화유도용조성물및 이를이용한암 줄기세포분화유도방법에관한것으로, 구체적으로, 본발명은세쿠리닌(securinine)이암 줄기세포의분화를유도하고, 암세포내 암줄기세포를선택적으로사멸시킬수 있는효과가있음을밝히고이를통해본 발명의조성물이암 줄기세포의존재가알려진다양한암 종의분화유도에적용가능하고, 단독으로혹은기존의항암제와병행사용하여암의전이또는재발을효과적으로억제할수 있음을확인하였으며, 따라서암 질환에대한치료및 예방에유용하게이용될수 있다.

Abstract translation: 本发明涉及包含硫嘌呤作为诱导癌症干细胞分化的活性成分的组合物，以及使用该组合物诱导癌干细胞分化的方法。 更具体地说，本发明揭示了证实蛋白诱导癌症干细胞的分化，并且可以选择性地破坏癌细胞中的癌干细胞。 本发明的组合物可以用于诱导已知具有癌干细胞的各种癌症种类的分化，并且可以通过单独使用组合物或与常规抗癌剂组合来有效地抑制癌症的复发和转移，由此 可用于治疗和预防癌症疾病。

公开(公告)号：KR1020100135063A

公开(公告)日：2010-12-24

申请号：KR1020090053513

申请日：2009-06-16

Applicant: 성균관대학교산학협력단

Inventor： 박정민 ,  이은석 ,  민동욱 ,  고재헌 ,  김영덕 ,  서정범 ,  김훈기 ,  이현숙 ,  정석용

IPC: B25J9/16 ,  B25J19/06 ,  B25J9/22

Abstract: PURPOSE: A self-healing method of an intelligent robot, a recording media in which the self-healing method is recorded, and a self-healing system of an intelligent robot are provided to sense defined errors through monitoring and to correct the errors by itself based on a designed healing strategy. CONSTITUTION: A self-healing method of an intelligent robot is as follows. Errors which are likely to be generated are defined as an intelligent robot. A healing strategy about defined possible error is designed. The intelligent robot detects errors based on the defined possible errors and cures the error detected based on the designed healing strategy.

Abstract translation: 目的：提供智能机器人的自愈方法，记录自愈方法的记录介质和智能机器人的自我修复系统，以通过监控来感测定义的错误并自行纠正错误 基于设计的治疗策​​略。 构成：智能机器人的自愈方法如下。 可能产生的错误被定义为智能机器人。 设计了关于定义的可能错误的愈合策略。 智能机器人根据定义的可能的错误检测错误，并根据设计的治疗策​​略治愈检测到的错误。

公开(公告)号：KR101539205B1

公开(公告)日：2015-07-24

申请号：KR1020150056693

申请日：2015-04-22

Applicant: 성균관대학교산학협력단

Inventor： 김경규 ,  이현숙 ,  데보죠티데

IPC: A61K31/55 ,  C12N5/07

Abstract: 본발명은세쿠리닌(securinine)을유효성분으로포함하는암 줄기세포분화유도용조성물및 이를이용한암 줄기세포분화유도방법에관한것으로, 구체적으로, 본발명은세쿠리닌(securinine)이암 줄기세포의분화를유도하고, 암세포내 암줄기세포를선택적으로사멸시킬수 있는효과가있음을밝히고이를통해본 발명의조성물이암 줄기세포의존재가알려진다양한암 종의분화유도에적용가능하고, 단독으로혹은기존의항암제와병행사용하여암의전이또는재발을효과적으로억제할수 있음을확인하였으며, 따라서암 질환에대한치료및 예방에유용하게이용될수 있다.

公开(公告)号：KR1020140061277A

公开(公告)日：2014-05-21

申请号：KR1020130137240

申请日：2013-11-12

Applicant: 성균관대학교산학협력단

Inventor： 김경규 ,  이현숙 ,  데보죠티데

IPC: A61K31/55 ,  C12N5/095 ,  A61P35/00

CPC classification number: A61K31/55 ,  C12N5/06

Abstract: The present invention relates to a composition comprising securinine as an active ingredient for inducing differentiation of a cancer stem cell and a method for inducing differentiation of a cancer stem cell by using the same. More specifically, the present invention reveals that the securinine incudes differentiation of the cancer stem cell and can selectively destroy the cancer stem cell in cancer cells. The composition of the present invention can be applied for inducing differentiation of a variety of cancer species which is known to have cancer stem cells, and can effectively suppress recurrence and metastasis of cancer by using the composition alone or combined with a conventional anticancer agent; thereby can be used for treating and preventing cancer diseases.

Abstract translation: 本发明涉及一种组合物，其包含作为诱导癌症干细胞分化的活性成分的硫嘌呤，以及通过使用该组合物诱导癌症干细胞分化的方法。 更具体地，本发明揭示了证实蛋白质包括癌干细胞的分化，并且可以选择性地破坏癌细胞中的癌干细胞。 本发明的组合物可用于诱导已知具有癌症干细胞的各种癌症种类的分化，并且可以通过单独使用组合物或与常规抗癌剂组合来有效地抑制癌症的复发和转移; 从而可用于治疗和预防癌症疾病。

公开(公告)号：KR101543863B1

公开(公告)日：2015-08-11

申请号：KR1020130137240

申请日：2013-11-12

Applicant: 성균관대학교산학협력단

Inventor： 김경규 ,  이현숙 ,  데보죠티데

IPC: A61K31/55 ,  C12N5/095 ,  A61P35/00

Abstract: 본발명은세쿠리닌(securinine)을유효성분으로포함하는암 줄기세포분화유도용조성물및 이를이용한암 줄기세포분화유도방법에관한것으로, 구체적으로, 본발명은세쿠리닌(securinine)이암 줄기세포의분화를유도하고, 암세포내 암줄기세포를선택적으로사멸시킬수 있는효과가있음을밝히고이를통해본 발명의조성물이암 줄기세포의존재가알려진다양한암 종의분화유도에적용가능하고, 단독으로혹은기존의항암제와병행사용하여암의전이또는재발을효과적으로억제할수 있음을확인하였으며, 따라서암 질환에대한치료및 예방에유용하게이용될수 있다.