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公开(公告)号：KR1020100104370A
公开(公告)日：2010-09-29
申请号：KR1020090022744
申请日：2009-03-17
Applicant: 성균관대학교산학협력단
IPC: G01N33/534 , G01N33/574
Abstract: PURPOSE: A tracer of quantum dot base for multi-mode imaging of epidermal growth factor receptor(EGFR) is provided to evaluate in vivo EGFR by optical imaging and radiation signal. CONSTITUTION: A tracer of quantum dot base comprises: a polyethylene glycol(PEG) which is connected with compatible substance; a EGF(epidermal growth factor) which is conjugated with polyethylene glycol at one end; and radioactive isotope which is labeled with a bio molecule. The quantum dot is obtained by coating ZnS shell to a Cd/Se core. A method for preparing the tracer comprises: a step of preparing the quantum dot coated with bio molecule; a step of conjugating the polyethylene glycol to one end of the EGF; a step of reacting coated bio molecule; and a step of labeling radioactive isotope.
Abstract translation: 目的：提供用于表皮生长因子受体（EGFR）的多模式成像的量子点基因的示踪剂，以通过光学成像和辐射信号评价体内EGFR。 构成：量子点基的示踪剂包括：与相容物质相连的聚乙二醇（PEG）; 在一端与聚乙二醇缀合的EGF（表皮生长因子）; 和用生物分子标记的放射性同位素。 通过将ZnS壳涂覆到Cd / Se芯上获得量子点。 制备示踪剂的方法包括：制备涂有生物分子的量子点的步骤; 将聚乙二醇与EGF的一端缀合的步骤; 涂层生物分子的反应步骤; 以及标记放射性同位素的步骤。
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公开(公告)号：KR101899209B1
公开(公告)日：2018-09-14
申请号：KR1020160086812
申请日：2016-07-08
Applicant: 성균관대학교산학협력단
Abstract: 본발명은 NIS(sodium/iodide symporter)와 mODC(mouse ornithine decarboxylase degradation domain)이결합된재조합융합단백질, 이를암호화하는재조합폴리뉴클레오타이드, 이를포함하는발현벡터, 및이를이용한세포영상화또는치료방법에관한것이다. 본발명에의하면, 생체내암줄기세포와프로테아좀활성이낮은세포, 프로테아좀억제제로치료를받은세포를실시간으로검출하고추적할수 있는새로운분자영상기술을제공할뿐만아니라, 치료용방사성요오드를이용함으로써표적세포를제거하는치료기술로도활용할수 있다.
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公开(公告)号：KR1020170007183A
公开(公告)日：2017-01-18
申请号：KR1020160086812
申请日：2016-07-08
Applicant: 성균관대학교산학협력단
Abstract: 본발명은 NIS(sodium/iodide symporter)와 mODC(mouse ornithine decarboxylase degradation domain)이결합된재조합융합단백질, 이를암호화하는재조합폴리뉴클레오타이드, 이를포함하는발현벡터, 및이를이용한세포영상화또는치료방법에관한것이다. 본발명에의하면, 생체내암줄기세포와프로테아좀활성이낮은세포, 프로테아좀억제제로치료를받은세포를실시간으로검출하고추적할수 있는새로운분자영상기술을제공할뿐만아니라, 치료용방사성요오드를이용함으로써표적세포를제거하는치료기술로도활용할수 있다.
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