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    포유류 질병에 관여하는 신장 특이적 유전자 ＨＭＭ02
    2.
    发明公开
    포유류 질병에 관여하는 신장 특이적 유전자 ＨＭＭ02 有权
    KIDNEY特异基因HMM02与KIDNEY CYST的发展相关

    公开(公告)号：KR1020080078230A

    公开(公告)日：2008-08-27

    申请号：KR1020070018049

    申请日：2007-02-22

    Applicant: 숙명여자대학교산학협력단

    Inventor： 박종훈 ,  허철구 ,  문제선 ,  최서희 ,  박소영 ,  노승재 ,  김정선 ,  백효정 ,  최준경 ,  권석윤

    IPC: C07K14/47 ,  C12N15/66

    Abstract: An HMM02 gene involving with an attack of renal cyst is provided to be specifically expressed in kidney tissues, thereby decreasing false positive during the study of cyst symptoms, diagnosing the renal cyst easily and treating the renal cyst in early stage. An HMM02 protein consists of an amino acid sequence of SEQ ID : NO. 2, wherein the protein is derived from mammal. A gene encoding the HMM02 protein consists of a sequence of SEQ ID : NO. 1. A transformant is transformed by a recombinant vector including the gene. A marker for diagnosing the attack of the renal cyst comprises the sequence of SEQ ID : NO. 1. A microarray for diagnosing the attack of the renal cyst comprises the sequence of SEQ ID : NO. 1 or an antibody against the protein. A method for treating the renal cyst of a test animal comprises a step of inhibiting the expression of the gene in the test animal. Further, the test animal is a pet such as dog or cat, a domestic animal such as pig or caw, mouse, zebrafish or Drosophila.

    Abstract translation: 提供涉及肾囊肿攻击的HMM02基因在肾组织中特异性表达，从而在囊肿症状研究期间容易地减少假阳性，容易诊断肾囊肿，并在早期治疗肾囊肿。 HMM02蛋白由SEQ ID NO：1的氨基酸序列组成。 2，其中所述蛋白质衍生自哺乳动物。 编码HMM02蛋白的基因由SEQ ID NO： 转化体由包含该基因的重组载体转化。 用于诊断肾囊肿发作的标记物包含SEQ ID NO： 用于诊断肾囊肿发作的微阵列包含SEQ ID NO：1的序列。 1或针对蛋白质的抗体。 用于治疗测试动物的肾囊肿的方法包括抑制测试动物中基因表达的步骤。 此外，试验动物是宠物如狗或猫，家畜如猪或爪，小鼠，斑马鱼或果蝇。

    포유류 질병에 관여하는 신장 특이적 유전자 ＨＭＭ03
    4.
    发明公开
    포유류 질병에 관여하는 신장 특이적 유전자 ＨＭＭ03 有权
    KIDNEY特异基因HMM03与KIDNEY CYST的发展相关

    公开(公告)号：KR1020080078231A

    公开(公告)日：2008-08-27

    申请号：KR1020070018051

    申请日：2007-02-22

    Applicant: 숙명여자대학교산학협력단

    Inventor： 박종훈 ,  허철구 ,  문제선 ,  최서희 ,  박소영 ,  노승재 ,  김정선 ,  백효정 ,  최준경 ,  권석윤

    IPC: C07K14/47 ,  C12N15/66

    Abstract: An HMM03 gene is provided to be involved with an attack of renal cyst and be specifically expressed in kidney tissues, thereby decreasing false positive during the study of cyst symptoms, being used as a marker for diagnosing the renal cyst attack and treating the renal cyst rapidly in early stage by reducing a drug target to a protein regarding the HMM03. An HMM03 protein specifically expressed in kidney tissues consists of an amino acid sequence of SEQ ID : NO. 2 and is used as a target of a therapeutic drug of renal cyst, wherein the protein is derived from mammal. A gene encoding the HMM03 protein consists of a sequence of SEQ ID : NO. 1. A marker or a microarray for diagnosing the attack of the renal cyst comprises the sequence of SEQ ID : NO. 1. To treat the renal cyst of a test animal, which is a non-human animal such as dog, cat, pig, cow, mouse, zebrafish and drosophila, the expression of the gene in the test animal is inhibited.

    Abstract translation: 提供HMM03基因涉及肾囊肿的攻击，并在肾组织中特异性表达，从而在研究囊肿症状期间减少假阳性，用作诊断肾囊肿发作和快速治疗肾囊肿的标志物 在早期阶段通过将药物靶标减少到关于HMM03的蛋白质。 在肾组织中特异性表达的HMM03蛋白由SEQ ID NO：1的氨基酸序列组成。 2并用作肾囊肿治疗药物的靶标，其中蛋白质衍生自哺乳动物。 编码HMM03蛋白的基因由SEQ ID NO： 用于诊断肾囊肿发作的标记物或微阵列包含SEQ ID NO：1的序列。 1.为了治疗作为非人动物如狗，猫，猪，牛，小鼠，斑马鱼和果蝇的测试动物的肾囊肿，该受试动物中基因的表达被抑制。

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