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公开(公告)号：KR101374221B1
公开(公告)日：2014-03-14
申请号：KR1020120037960
申请日：2012-04-12
Applicant: 숭실대학교산학협력단
Abstract: 본 발명은 TiO
2
나노 입자-안트라사이클린계 화합물의 복합체, 이를 포함하는 약물 전달 시스템에 관한 것이다. 본 발명에 따른 TiO
2
나노 입자-안트라사이클린계화합물의 복합체는 세포 또는 생체에서 안정성이 있어, 안트라사이클린계 화합물을 안전하게 세포 또는 생체에 약물을 전달하고, 방출시킬 수 있으며, 상기 복합체를 이용하여 약물의 전달 및 방출과정을 실시간으로 관찰할 수 있다.-
公开(公告)号：KR1020130115565A
公开(公告)日：2013-10-22
申请号：KR1020120037960
申请日：2012-04-12
Applicant: 숭실대학교산학협력단
CPC classification number: A61K47/52 , A61K47/183 , A61K2121/00
Abstract: PURPOSE: A composite of titanium dioxide nanoparticles and anthracycline-based compounds is provided to show stability in cells or organisms, thereby safely delivering and releasing a drug to the cells or the organisms. CONSTITUTION: A composite of titanium dioxide nanoparticles and anthracycline-based compounds is provided. A drug delivery system has the composite and glutathione. A method for delivering and releasing a drug comprises the steps of: binding the titanium dioxide nanoparticles and the anthracycline-based compounds and forming the composite; treating cells or organisms with the composite; treating the cells or organisms with glutathione; and separating the anthracycline-based compounds and the titanium dioxide nanoparticles and releasing the anthracycline-based compounds.
Abstract translation: 目的：提供二氧化钛纳米颗粒和蒽环类化合物的复合物，以显示细胞或生物体的稳定性，从而将药物安全地递送和释放到细胞或生物体中。 构成：提供二氧化钛纳米颗粒和蒽环类化合物的复合物。 药物输送系统具有复合物和谷胱甘肽。 用于递送和释放药物的方法包括以下步骤：结合二氧化钛纳米颗粒和基于蒽环类化合物并形成复合物; 用复合材料处理细胞或生物体; 用谷胱甘肽处理细胞或生物体; 并分离蒽环类化合物和二氧化钛纳米颗粒并释放蒽环类化合物。
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