公开(公告)号：KR1020090059017A

公开(公告)日：2009-06-10

申请号：KR1020080020870

申请日：2008-03-06

Applicant: 신풍제약주식회사

Inventor： 노정열 ,  강수현 ,  하경욱

IPC: A61K31/216 ,  A61K31/222 ,  A61K31/255

Abstract: A pharmaceutical composition for treating liver disease and improving liver function is provided to enhance the treatment effect of liver disease by mixing two kinds of antioxidant. A pharmaceutical composition for treating liver disease and improving liver function comprises biphenyl methyl dicarboxylate and arginine thiozolidine carboxylate in a weight ratio of 1-25:1-200 as active ingredients. The pharmaceutical composition contains 25mg of biphenyl methyl dicarboxylate and 200mg of arginine thiozolidine carboxylate. The pharmaceutical composition further comprises at least one of pharmaceutically allowable carrier. The composition is used in a form of tablet, capsule or suspension.

Abstract translation: 提供一种治疗肝脏疾病和改善肝功能的药物组合物，通过混合两种抗氧化剂来提高肝脏疾病的治疗效果。 用于治疗肝脏疾病和改善肝功能的药物组合物包括重量比为1-25：1-200的联苯甲基二羧酸酯和精氨酸硫唑烷羧酸盐作为活性成分。 药物组合物含有25mg联苯甲基二羧酸酯和200mg精氨酸硫唑烷羧酸盐。 药物组合物还包含药学上可允许的载体中的至少一种。 组合物以片剂，胶囊或悬浮液的形式使用。

公开(公告)号：KR100798730B1

公开(公告)日：2008-01-29

申请号：KR1020060052606

申请日：2006-06-12

Applicant: 신풍제약주식회사

Inventor： 김기원 ,  노정열 ,  임춘수 ,  김원준 ,  강수현

IPC: A61K9/28 ,  A61K9/22

Abstract: 본 발명은 활성성분으로서 록소프로펜, 잘토프로펜 또는 이들의 염을 각각 함유하는 서방출성 내부핵층 및 속방출성 외부코팅층을 동시에 포함하는 제어방출성 경구용 제제에 관한 것이다.
본 발명에 의해 약물의 체내 방출을 이중으로 제어하게 되면, 속방출성 외부코팅층에 함유된 활성약물이 신속하게 혈중농도를 높이고 서방출성 내부핵층에서 활성약물이 서서히 방출되어 장시간 치료적으로 유용한 혈중농도를 유지시키는 효과가 있다.
록소프로펜, 잘토프로펜, 서방출성, 속방출성

公开(公告)号：KR1020070118444A

公开(公告)日：2007-12-17

申请号：KR1020060052606

申请日：2006-06-12

Applicant: 신풍제약주식회사

Inventor： 김기원 ,  노정열 ,  임춘수 ,  김원준 ,  강수현

IPC: A61K9/28 ,  A61K9/22

CPC classification number: A61K9/2893 ,  A61K9/2853 ,  A61K9/286 ,  A61K9/2866 ,  A61K31/192 ,  A61K31/38

Abstract: A controlled-release formulation containing loxoprofen or zaltoprofen is provided to maintain effective concentration of drugs in blood for a long period of time by rapidly increasing blood concentration of active drug in an outer coating layer and slowly releasing the active drug in an inner core layer, thereby reducing an administration time. A controlled-release formulation contains a sustained-release inner core layer and a fast-release outer coating layer containing loxoprofen, zaltoprofen or its salts, respectively, wherein the sustained-release inner core layer contains an active ingredient and a matrix-forming agent and is coated by an enteric coating material, and the fast-release outer coating layer contains an active ingredient and strong disintegrant. The enteric coating material is cellulose ester derivatives, cellulose ether or acryl resin.

Abstract translation: 提供含有洛索洛芬或扎洛芬的控制释放制剂，以通过快速增加外部涂层中的活性药物的血液浓度并缓慢释放内核层中的活性药物来长时间维持药物在血液中的有效浓度， 从而减少给药时间。 缓释制剂包含分别含有洛索洛芬，唑洛芬或其盐的缓释内芯层和快速释放外涂层，其中缓释内芯层含有活性成分和基质形成剂， 被肠溶衣材料包覆，快速释放外涂层含有活性成分和强崩解剂。 肠溶衣材料是纤维素酯衍生物，纤维素醚或丙烯酸树脂。