公开(公告)号：KR100679166B1

公开(公告)日：2007-02-06

申请号：KR1020050093008

申请日：2005-10-04

Applicant: 신풍제약주식회사

Inventor： 박우일 ,  노정열 ,  김우경 ,  구민수 ,  장석영

IPC: A61K9/16 ,  A61K31/403

Abstract: A pharmaceutical composition comprising ramipril is provided to show excellent stability against mechanical stress by granulation with mannitol solution. And a method for preparing a pharmaceutical formulation comprising stabilized ramipril is provided to simplify the preparation process, thereby obtaining the ramipril containing formulation within short period of time and maintaining the stability of the formulation for a long time. The pharmaceutical composition is characterized in that ramipril as an active ingredient is granulated with mannitol solution. In the composition, the weight ratio of the ramipril to mannitol is 1:0.25-1. The pharmaceutical oral formulation comprises the pharmaceutical composition and a pharmaceutically acceptable excipient.

Abstract translation: 提供包含雷米普利的药物组合物，以通过用甘露糖醇溶液造粒显示优异的抗机械应激稳定性。 并且提供了一种用于制备包含稳定的雷米普利的药物制剂的方法，以简化制备过程，从而在短时间内获得含有雷米普利的制剂并长时间保持制剂的稳定性。 该药物组合物的特征在于作为活性成分的雷米普利与甘露醇溶液一起造粒。 在该组合物中，雷米普利与甘露糖醇的重量比为1:0.25-1。 药物口服制剂包含药物组合物和药学上可接受的赋形剂。