公开(公告)号：KR100399195B1

公开(公告)日：2003-09-26

申请号：KR1020010013859

申请日：2001-03-17

Applicant: 신풍제약주식회사

Inventor： 이성태 ,  한신 ,  박우일 ,  김형태

IPC: C07D501/12

Abstract: PURPOSE: Provided is a process for preparing amorphous form of cefuroxime axetil, thereby producing amorphous form of cefuroxime axetil, which is excellent in elution in a living body and has stability, in high yield and purity. CONSTITUTION: The amorphous cefuroxime axetil represented by the formula(1) is manufactured by the steps of: dissolving cefuroxime axetil in a polar organic solvent; passing CO2 gas therethrough; and adding a water soluble solution containing inorganic salts to precipitate amorphous cefuroxime axetil.

Abstract translation: 用途：提供一种制备无定形头孢呋辛酯的方法，由此制得无定形形式的头孢呋辛酯，其在生物体中洗脱性能优异，并且具有稳定性，高产率和纯度。 构成：由式（1）表示的无定形头孢呋辛酯通过以下步骤制备：将头孢呋辛酯溶解在极性有机溶剂中; 通过二氧化碳气体; 并加入含有无机盐的水溶性溶液以沉淀无定形头孢呋辛酯。

公开(公告)号：KR1020020073918A

公开(公告)日：2002-09-28

申请号：KR1020010013859

申请日：2001-03-17

Applicant: 신풍제약주식회사

Inventor： 이성태 ,  한신 ,  박우일 ,  김형태

IPC: C07D501/12

Abstract: PURPOSE: Provided is a process for preparing amorphous form of cefuroxime axetil, thereby producing amorphous form of cefuroxime axetil, which is excellent in elution in a living body and has stability, in high yield and purity. CONSTITUTION: The amorphous cefuroxime axetil represented by the formula(1) is manufactured by the steps of: dissolving cefuroxime axetil in a polar organic solvent; passing CO2 gas therethrough; and adding a water soluble solution containing inorganic salts to precipitate amorphous cefuroxime axetil.

Abstract translation: 目的：提供头孢呋辛酯无定形形式的方法，由此生产无机形式的头孢呋辛酯，其在生物体中的洗脱性优异且稳定性高，产率高，纯度高。 构成：由式（1）表示的无定形头孢呋辛酯通过以下步骤制造：将头孢呋辛酯在极性有机溶剂中溶解; 使二氧化碳气体通过; 并加入含有无机盐的水溶性溶液以沉淀无定形头孢呋辛酯。