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公开(公告)号：WO2016093601A1
公开(公告)日：2016-06-16
申请号：PCT/KR2015/013405
申请日：2015-12-08
Applicant: 썬텍 주식회사
CPC classification number: A61F2/958 , A61F2/91 , A61F2002/9522 , A61F2210/0004 , A61F2210/0014 , A61L27/58 , A61L31/06 , A61L31/14 , A61L31/148 , A61L2400/16
Abstract: 본 출원은 생분해성 스텐트 및 이의 형상기억 확장방법에 관한 것이다. 본 출원의 일 실시상태에 따르면, 생분해성 스텐트의 형상기억 확장방법을 통해 생분해성 스텐트의 반지름방향 힘이 크게 증가하고, 크림핑 및 스텐트 전개 후 크랙의 수가 감소할 수 있다.
Abstract translation: 本申请涉及一种可生物降解支架及其形状记忆扩展方法。 根据本申请的一个实施例，可生物降解的支架的径向力可以通过生物可降解支架的形状记忆扩展方法大大增加，并且在压接和支架展开之后可以减少裂纹的数量。
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公开(公告)号：KR101682210B1
公开(公告)日：2016-12-02
申请号：KR1020150174466
申请日：2015-12-08
Applicant: 썬텍 주식회사
CPC classification number: A61F2/958 , A61F2/91 , A61F2002/9522 , A61F2210/0004 , A61F2210/0014 , A61L27/58 , A61L31/06 , A61L31/14 , A61L31/148 , A61L2400/16
Abstract: 본출원은생분해성스텐트및 이의형상기억확장방법에관한것이다. 본출원의일 실시상태에따르면, 생분해성스텐트의형상기억확장방법을통해생분해성스텐트의반지름방향힘이크게증가하고, 크림핑및 스텐트전개후 크랙의수가감소할수 있다.
Abstract translation: 本申请涉及一种可生物降解支架及其形状记忆扩展方法。 根据本申请的一个实施例，可生物降解的支架的径向力可以通过生物可降解支架的形状记忆扩展方法大大增加，并且在压接和支架展开之后可以减少裂纹的数量。
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公开(公告)号：KR101138294B1
公开(公告)日：2012-04-25
申请号：KR1020080093574
申请日：2008-09-24
CPC classification number: A61L31/041 , A61F2/82 , A61F2210/0004 , A61L27/14 , A61L27/26 , A61L27/507 , A61L31/148 , A61L2300/80 , C08L101/02 , C08L67/04
Abstract: A bioabsorbable blend comprising poly(L-lactide) (PLLA) and a phosphorylcholine group-containing copolymer (PPCP) capable of enduring the mechanical strength of blood vessel walls and applicable for fabricating cardiovascular devices was developed. The blend acts as a scaffold to support blood vessel walls during vascular healing and undergoes biodegradation in vivo after vascular healing is complete. Furthermore, the blend can prevent the formation and adsorption of thrombi.
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公开(公告)号：KR1020140011503A
公开(公告)日：2014-01-29
申请号：KR1020120065667
申请日：2012-06-19
Applicant: 썬텍 주식회사
IPC: A61F2/82 , A61L27/14 , A61L27/54 , C08L101/16
Abstract: The present invention relates to a method for manufacturing a biodegradable polymeric stent on which dual drug is coated which comprises: a first coating layer formation step which forms the first coating layer by spraying one surface of a cylinder formed with biodegradable polymers with a drug; a first dry step which dries the first coating layer formed in the first coating layer formation step; a second coating layer formation step which sprays the other surface of the cylinder with the drug after the first dry step; a second dry step which dries the second coating layer formed in the second coating layer formation step; and a laser processing step which removes a part of the cylinder by irradiating the cylinder with femtosecond laser after the second dry step. Therefore the present invention provides a technique which forms dual drug layers on the biodegradable polymeric stent. According to the present invention, the first and second coating layers are formed before the laser processing step so that each drug can be uniformly coated on the inner and outer circumferences of the cylinder which is formed with the biodegradable polymers, and heat loss is not generated around struts which form the stent so that a separate surface treatment is not required.
Abstract translation: 本发明涉及一种制造双重药物的可生物降解的聚合物支架的方法，其包括：第一涂层形成步骤，通过将形成有可生物降解的聚合物的圆筒的一个表面与药物喷射而形成第一涂层; 第一干燥步骤，其干燥在所述第一涂层形成步骤中形成的所述第一涂层; 第二涂层形成步骤，在所述第一干燥步骤之后，用所述药物喷射所述圆筒的另一个表面; 第二干燥步骤，其干燥在所述第二涂层形成步骤中形成的所述第二涂层; 以及激光加工步骤，通过在第二干燥步骤之后用飞秒激光照射圆筒来去除圆筒的一部分。 因此，本发明提供了一种在可生物降解的聚合物支架上形成双重药物层的技术。 根据本发明，在激光加工步骤之前形成第一和第二涂层，使得每种药物均匀地涂覆在由可生物降解的聚合物形成的圆筒的内周和外周上，并且不产生热损失 围绕形成支架的支柱，使得不需要单独的表面处理。
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公开(公告)号：KR1020130101673A
公开(公告)日：2013-09-16
申请号：KR1020120021414
申请日：2012-02-29
Applicant: 썬텍 주식회사
CPC classification number: A61F2/82 , A61F2002/826 , A61F2230/0082
Abstract: PURPOSE: A stent for treating stenosis is provided to effectively disperse pressure applied from the outside of the stent by deforming the stent into a hexagon form when the diameter of the stent is expanding. CONSTITUTION: A stent (10) for treating stenosis includes an upper curved unit, a lower curved unit, and plural supporting units. Plural curves are formed on the upper curved unit. The lower curved unit is separated from the upper curved unit to the longitudinal direction of the stent, and has a vertically symmetrical shape with the upper curved unit. The supporting units connect the upper and lower curved units. The upper and lower curved units form one cell by being connected by the supporting units. One cell shares the supporting units with another cell, and forms a successive cell form along the circumference direction of the stent.
Abstract translation: 目的：提供一种用于治疗狭窄的支架，用于当支架的直径扩大时，通过使支架变形为六边形，从而有效地分散从支架外部施加的压力。 构成：用于治疗狭窄的支架（10）包括上弯曲单元，下弯曲单元和多个支撑单元。 在上弯曲单元上形成多条曲线。 下弯曲单元与上弯曲单元相对于支架的纵向方向分离，并且具有与上弯曲单元垂直对称的形状。 支撑单元连接上下弯曲单元。 上下弯曲单元通过由支撑单元连接而形成一个单元。 一个细胞与另一个细胞共享支持单元，并且沿着支架的圆周方向形成连续的细胞形式。
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Patent Agency Ranking
公开(公告)号：KR1020130141805A
公开(公告)日：2013-12-27
申请号：KR1020120064788
申请日：2012-06-18
Applicant: 썬텍 주식회사
Abstract: Nanosized holes generated in electrospun nanofibers can supply oxygen, nutrients, growth factors etc. to the tissue. The present invention relates to an electrospun nanofiber structure of first poly(L-lactide-co-caprolactone-co-glycolide)(PLCG). PMB30W and rapamycin are contained, and mixed polymer soluble in water is added to PLCG after solvent mixing and electric spinning. The electrospun PLCG/PMB30W/rapamycin mixed fiber has a stable nanostructure without a chemical cross combination while being cultured in a buffer solution. The characteristic of the PMB30W and hydrophobic rapamycin natural material can stabilize the electrospun PLCG/PMB30W/rapamycin mixed fiber under physiological conditions. The electrospun PLCG/PMB30W/rapamycin mixed fiber might be better for artificial organs of tissue engineering.
Abstract translation: 在电纺丝纳米纤维中产生的纳米孔可以向组织中提供氧气，营养物质，生长因子等。 本发明涉及第一种聚（L-丙交酯 - 共 - 己内酯 - 共 - 乙交酯）（PLCG）的电纺丝纳米纤维结构。 含有PMB30W和雷帕霉素，溶剂混合和电纺后将可溶于水的混合聚合物加入到PLCG中。 电纺PLCG / PMB30W /雷帕霉素混合纤维在缓冲溶液中培养时具有稳定的纳米结构，无化学交叉组合。 PMB30W和疏水雷帕霉素天然材料的特点可以在生理条件下稳定电纺PLCG / PMB30W /雷帕霉素混合纤维。 电纺PLCG / PMB30W /雷帕霉素混合纤维对于组织工程的人造器官可能更好。
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公开(公告)号：KR1020130141260A
公开(公告)日：2013-12-26
申请号：KR1020120064537
申请日：2012-06-15
Applicant: 썬텍 주식회사
Abstract: The present invention relates to a biodegradable cardiovascular stent. The biodegradable cardiovascular stent comprises: a first curve part having at least four curves; and a second curve part connected to one side of the first curve part and having a left-right symmetric shape with the first curve part. The first curve part and the second curve part are connected to each other to form one cell. The cell is connected to another cell neighboring thereon in a horizontal direction. Multiple cells connected in the horizontal direction constitute a column, which is then wound to form a cylindrical body. This constitution enables a stent structure having excellent expansion force and flexibility. According to the present invention, since multiple curves are formed on the first curve part and the second curve part constituting each cell, the material density of the stent is increased. As the material density of the stent is increased, the stent inserted into the stenosed region is excellent in the degree of expansion in a hollow radial direction.
Abstract translation: 本发明涉及可生物降解的心血管支架。 可生物降解的心血管支架包括：具有至少四条曲线的第一曲线部分; 以及第二曲线部分，其连接到第一曲线部分的一侧，并且具有带有第一曲线部分的左右对称形状。 第一曲线部分和第二曲线部分彼此连接以形成一个单元。 单元在水平方向上连接到与其相邻的另一个单元。 在水平方向上连接的多个单元构成一列，然后将其卷绕形成圆柱体。 该结构能够实现具有优异的膨胀力和柔韧性的支架结构。 根据本发明，由于在构成每个电池单元的第一曲线部分和第二曲线部分上形成多个曲线，所以支架的材料密度增加。 随着支架的材料密度增加，插入狭窄区域的支架在中空径向膨胀的程度上是优异的。
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公开(公告)号：KR101336187B1
公开(公告)日：2013-12-05
申请号：KR1020130012877
申请日：2013-02-05
Applicant: 썬텍 주식회사
Inventor： 김형일
IPC: C08F230/02 , C08F220/10 , C08L43/02 , C08L101/02
CPC classification number: C08F220/36 , A61K47/32 , A61K47/34 , C08F2/38 , C08F30/02 , C08F220/18 , C08F230/02
Abstract: The present invention relates to a method for synthesizing a random copolymer including phosphorylcholine groups. When synthesizing, reaction mixture containing chain transfer agent (CTA), a solvent, a hydrophobic monomer, methacrylate, 2-acryloyloxyethyl meth phosphoryl choline (MPC) monomer and selectively initiator is used. The synthesis random copolymer produced by using the method has the ratio (Mw / Mn) of weight average molecular weight to the number average molecular weight of 1.3 or less and peak molecular weight (Mp) of 130,000 or less. The present invention also relates to, and a method for treating mammals by using a polymer blend including, the random copolymer, and medical devices.
Abstract translation: 本发明涉及一种合成含有磷酸胆碱基团的无规共聚物的方法。 当合成时，使用含有链转移剂（CTA），溶剂，疏水性单体，甲基丙烯酸酯，2-丙烯酰氧基乙基甲基磷酰胆碱（MPC）单体和选择性引发剂的反应混合物。 使用该方法制造的合成无规共聚物的重均分子量（Mw / Mn）与数均分子量的比值为1.3以下，峰值分子量（Mp）为13万以下。 本发明还涉及通过使用包含无规共聚物和医疗装置的聚合物共混物来治疗哺乳动物的方法和方法。
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