公开(公告)号：KR1020140011503A

公开(公告)日：2014-01-29

申请号：KR1020120065667

申请日：2012-06-19

Applicant: 썬텍 주식회사

Inventor： 김형일 ,  신일균 ,  조정애

IPC: A61F2/82 ,  A61L27/14 ,  A61L27/54 ,  C08L101/16

Abstract: The present invention relates to a method for manufacturing a biodegradable polymeric stent on which dual drug is coated which comprises: a first coating layer formation step which forms the first coating layer by spraying one surface of a cylinder formed with biodegradable polymers with a drug; a first dry step which dries the first coating layer formed in the first coating layer formation step; a second coating layer formation step which sprays the other surface of the cylinder with the drug after the first dry step; a second dry step which dries the second coating layer formed in the second coating layer formation step; and a laser processing step which removes a part of the cylinder by irradiating the cylinder with femtosecond laser after the second dry step. Therefore the present invention provides a technique which forms dual drug layers on the biodegradable polymeric stent. According to the present invention, the first and second coating layers are formed before the laser processing step so that each drug can be uniformly coated on the inner and outer circumferences of the cylinder which is formed with the biodegradable polymers, and heat loss is not generated around struts which form the stent so that a separate surface treatment is not required.

Abstract translation: 本发明涉及一种制造双重药物的可生物降解的聚合物支架的方法，其包括：第一涂层形成步骤，通过将形成有可生物降解的聚合物的圆筒的一个表面与药物喷射而形成第一涂层; 第一干燥步骤，其干燥在所述第一涂层形成步骤中形成的所述第一涂层; 第二涂层形成步骤，在所述第一干燥步骤之后，用所述药物喷射所述圆筒的另一个表面; 第二干燥步骤，其干燥在所述第二涂层形成步骤中形成的所述第二涂层; 以及激光加工步骤，通过在第二干燥步骤之后用飞秒激光照射圆筒来去除圆筒的一部分。 因此，本发明提供了一种在可生物降解的聚合物支架上形成双重药物层的技术。 根据本发明，在激光加工步骤之前形成第一和第二涂层，使得每种药物均匀地涂覆在由可生物降解的聚合物形成的圆筒的内周和外周上，并且不产生热损失 围绕形成支架的支柱，使得不需要单独的表面处理。

公开(公告)号：KR101296604B1

公开(公告)日：2013-08-14

申请号：KR1020120098247

申请日：2012-09-05

Applicant: 썬텍 주식회사 ,  부산대학교 산학협력단

Inventor： 김형일 ,  신일균 ,  김준홍

IPC: A61B17/00 ,  A61M25/09 ,  A61F2/24 ,  A61L27/14

CPC classification number: A61F2/2466 ,  A61F2/2451

Abstract: PURPOSE: A sheath for a mitral valve cerclage operation and a cerclage thread are provided to make an operation convenience by inserting the cerclage thread in which the stiffness is low into the sheath of a stretching state. CONSTITUTION: A guide wire (20) passes through a first lumen (12). A second lumen (14) comprises a cerclage thread (30). The cerclage thread is included within the second lumen. The second lumen is penetrated to an insertion end of a sheath. The second lumen is blocked in the insertion end of the sheath.

Abstract translation: 目的：提供用于二尖瓣结扎手术的护套和结扎线，以通过将刚度低的结扎线插入拉伸状态的护套来实现操作方便。 构成：导丝（20）穿过第一内腔（12）。 第二管腔（14）包括环形螺纹（30）。 环形螺纹包含在第二管腔内。 第二管腔穿透到鞘的插入端。 第二个内腔在护套的插入端被阻塞。

公开(公告)号：KR1020130141805A

公开(公告)日：2013-12-27

申请号：KR1020120064788

申请日：2012-06-18

Applicant: 썬텍 주식회사

Inventor： 김형일 ,  신일균 ,  조정애

IPC: D01F6/92 ,  D01D5/00 ,  A61L27/44 ,  D01F1/10

Abstract: Nanosized holes generated in electrospun nanofibers can supply oxygen, nutrients, growth factors etc. to the tissue. The present invention relates to an electrospun nanofiber structure of first poly(L-lactide-co-caprolactone-co-glycolide)(PLCG). PMB30W and rapamycin are contained, and mixed polymer soluble in water is added to PLCG after solvent mixing and electric spinning. The electrospun PLCG/PMB30W/rapamycin mixed fiber has a stable nanostructure without a chemical cross combination while being cultured in a buffer solution. The characteristic of the PMB30W and hydrophobic rapamycin natural material can stabilize the electrospun PLCG/PMB30W/rapamycin mixed fiber under physiological conditions. The electrospun PLCG/PMB30W/rapamycin mixed fiber might be better for artificial organs of tissue engineering.

Abstract translation: 在电纺丝纳米纤维中产生的纳米孔可以向组织中提供氧气，营养物质，生长因子等。 本发明涉及第一种聚（L-丙交酯 - 共 - 己内酯 - 共 - 乙交酯）（PLCG）的电纺丝纳米纤维结构。 含有PMB30W和雷帕霉素，溶剂混合和电纺后将可溶于水的混合聚合物加入到PLCG中。 电纺PLCG / PMB30W /雷帕霉素混合纤维在缓冲溶液中培养时具有稳定的纳米结构，无化学交叉组合。 PMB30W和疏水雷帕霉素天然材料的特点可以在生理条件下稳定电纺PLCG / PMB30W /雷帕霉素混合纤维。 电纺PLCG / PMB30W /雷帕霉素混合纤维对于组织工程的人造器官可能更好。

公开(公告)号：KR1020130141260A

公开(公告)日：2013-12-26

申请号：KR1020120064537

申请日：2012-06-15

Applicant: 썬텍 주식회사

Inventor： 김형일 ,  신일균 ,  조정애

IPC: A61F2/82 ,  A61F2/06

Abstract: The present invention relates to a biodegradable cardiovascular stent. The biodegradable cardiovascular stent comprises: a first curve part having at least four curves; and a second curve part connected to one side of the first curve part and having a left-right symmetric shape with the first curve part. The first curve part and the second curve part are connected to each other to form one cell. The cell is connected to another cell neighboring thereon in a horizontal direction. Multiple cells connected in the horizontal direction constitute a column, which is then wound to form a cylindrical body. This constitution enables a stent structure having excellent expansion force and flexibility. According to the present invention, since multiple curves are formed on the first curve part and the second curve part constituting each cell, the material density of the stent is increased. As the material density of the stent is increased, the stent inserted into the stenosed region is excellent in the degree of expansion in a hollow radial direction.

Abstract translation: 本发明涉及可生物降解的心血管支架。 可生物降解的心血管支架包括：具有至少四条曲线的第一曲线部分; 以及第二曲线部分，其连接到第一曲线部分的一侧，并且具有带有第一曲线部分的左右对称形状。 第一曲线部分和第二曲线部分彼此连接以形成一个单元。 单元在水平方向上连接到与其相邻的另一个单元。 在水平方向上连接的多个单元构成一列，然后将其卷绕形成圆柱体。 该结构能够实现具有优异的膨胀力和柔韧性的支架结构。 根据本发明，由于在构成每个电池单元的第一曲线部分和第二曲线部分上形成多个曲线，所以支架的材料密度增加。 随着支架的材料密度增加，插入狭窄区域的支架在中空径向膨胀的程度上是优异的。

公开(公告)号：KR101231197B1

公开(公告)日：2013-02-07

申请号：KR1020120104473

申请日：2012-09-20

Applicant: 썬텍 주식회사

Inventor： 김형일 ,  김소정 ,  신일균 ,  조정애

IPC: A61F2/82 ,  A61L27/14 ,  A61F2/06

CPC classification number: A61F2/90 ,  A61F2/915 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2210/0004 ,  A61F2240/001 ,  Y10T29/49826

Abstract: PURPOSE: A polymer stent is provided to improve mechanical strength and to reduce the thickness of the stent. CONSTITUTION: A polymer stent comprises a first hinge unit who is bent to the inner side of a unit cell, a unit cell(110) which is bent to the outside of the unit cell and faces the first hinge unit, and a repetition unit(300) which comprises a linker unit extended to the outside from the bent portion of the second hinge unit. The repetition unit is arranged to be connected to the bent portion of the first hinge unit.

Abstract translation: 目的：提供聚合物支架以提高机械强度并减少支架的厚度。 构成：聚合物支架包括弯曲到单元电池的内侧的第一铰链单元，弯曲到单元电池的外部并且面向第一铰链单元的单元电池（110）和重复单元（ 300），其包括从第二铰链单元的弯曲部分延伸到外部的连接器单元。 重复单元布置成连接到第一铰链单元的弯曲部分。