생체내 분해기간이 조절 가능한 생체적합성 소장점막하조직 하이드로젤의 제조방법
    2.
    发明公开
    생체내 분해기간이 조절 가능한 생체적합성 소장점막하조직 하이드로젤의 제조방법 有权
    制备体内降解时间可调节的生物降解小细胞亚型的水凝胶的方法

    公开(公告)号:KR1020130028562A

    公开(公告)日:2013-03-19

    申请号:KR1020110092202

    申请日:2011-09-09

    Abstract: PURPOSE: A manufacturing method of small intestine submucosa hydrogel is provided to control the decomposition period by the concentration of a cross-linking agent, and to form gel which is not easily decomposable by forming a bridge using the cross-linking agent. CONSTITUTION: A manufacturing method of bio-compatible small intestine submucosa hygrogel capable of controlling in vivo decomposition comprises: a small intestine submucosa solution manufacturing step mixing an acid solution and pepsin into the small intestine submucosa; a bio-compatible pH controlling step using a basic solution to the obtained solution; a powder manufacturing step cooling and drying the obtained solution; and a cross-link reacting step mixing a chemical cross-linking agent after solubilizing with the obtained powder. The chemical cross-linking agent is selected from an aldehyde group chemical, a water-soluble carboimide chemical, an epoxy chemical, and diisocyanate.

    Abstract translation: 目的:提供小肠粘膜下层水凝胶的制造方法,通过交联剂的浓度控制分解时间,通过使用交联剂形成桥,形成不容易分解的凝胶。 构成:能够控制体内分解的生物相容性小肠粘膜下胶凝胶的制造方法包括:将酸溶液和胃蛋白酶混合到小肠粘膜下层中的小肠粘膜下层溶液制造步骤; 使用所得溶液的碱性溶液的生物相容性pH控制步骤; 粉末制造步骤冷却并干燥所得溶液; 以及在获得的粉末溶解后将化学交联剂混合的交联反应步骤。 化学交联剂选自醛基化学品,水溶性碳酰亚胺化学品,环氧化学品和二异氰酸酯。

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