公开(公告)号：KR1020100045683A

公开(公告)日：2010-05-04

申请号：KR1020080104744

申请日：2008-10-24

Applicant: 아주대학교산학협력단

Inventor： 김용성 ,  권명희 ,  김동식

IPC: C07K16/42 ,  C07K16/18 ,  C07K16/00

Abstract: PURPOSE: A humanized antibody having nucleic acid hydrolysis ability and cancer cell infiltration ability is provided to specifically bind to and hydrolyze a nucleic acid and to ensure low immune reaction in a human body. CONSTITUTION: An immunoglobulin or single side chain antibody(scFv) fragment contains epitope of heavy chain variable region or light chain variable region. The immunoglobulin is immunoglobulin G, humanized 3D8 antibody. The heavy chain variable region is a protein comprising a sequence of sequence number 15. The VL is a protein comprising a sequence of sequence number 16. A composition for preventing or treating cancer contains the immunoglobulin or single side chain antibody(scFv) fragment as an active ingredient.

Abstract translation: 目的：提供具有核酸水解能力和癌细胞浸润能力的人源化抗体，以特异性结合并水解核酸并确保人体内的低免疫反应。 构成：免疫球蛋白或单侧链抗体（scFv）片段含有重链可变区或轻链可变区的表位。 免疫球蛋白是免疫球蛋白G，人源化3D8抗体。 重链可变区是包含序列号为15的序列的蛋白质.VL是包含序列号16的序列的蛋白质。用于预防或治疗癌症的组合物含有免疫球蛋白或单侧链抗体（scFv）片段，作为 有效成分。

公开(公告)号：KR101075123B1

公开(公告)日：2011-10-19

申请号：KR1020080104744

申请日：2008-10-24

Applicant: 아주대학교산학협력단

Inventor： 김용성 ,  권명희 ,  김동식

IPC: C07K16/42 ,  C07K16/18 ,  C07K16/00

Abstract: 본발명은핵산가수분해능 및암세포내침투능력을갖는인간화된항체및 그용도에관한것이다.