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1.发明授权
公开(公告)号：KR101236198B1
公开(公告)日：2013-02-22
申请号：KR1020110011278
申请日：2011-02-08
Applicant: 아주대학교산학협력단
CPC classification number: A61K47/34 , A61K9/0024 , A61K47/593 , A61K47/60 , A61L31/06 , A61L31/14 , A61L31/145 , A61L31/16 , C08G63/664 , C08G63/912 , C08G2261/126 , C08L71/02 , C08L2205/05 , C08L67/00 , C08L67/04
Abstract: 본 발명은 생체 작용 관능기가 곁사슬에 도입된 온도감응성 폴리에틸렌글리콜/폴리에스터 블록 공중합체의 제조 및 응용에 관한 것으로, 보다 구체적으로는 곁사슬에 벤질 에테르기가 도입된 락타이드 세그먼트를 포함하는 온도감응성 폴리에틸렌글리콜/폴리에스터 블록 공중합체 및 이의 제조방법에 관한 것이다. 본 발명에 따른 생체 작용 관능기가 곁사슬에 도입된 온도감응성 폴리에틸렌글리콜/폴리에스터 블록 공중합체는 곁사슬에 다양한 관능기를 가짐으로써, 약물을 함유하는 약물전달체와 조직공학용 지지체 등 다양한 분야에 사용될 수 있다.
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公开(公告)号：KR1020110093210A
公开(公告)日：2011-08-18
申请号：KR1020100013109
申请日：2010-02-12
Applicant: 아주대학교산학협력단
IPC: A61K9/16 , A61K47/30 , A61K31/573
CPC classification number: A61K9/1641 , A61K9/1682 , A61K31/192 , A61K31/216 , A61K31/573
Abstract: PURPOSE: A drug-containing polymer microsphere and a method for manufacturing the same are provided to enhance molecular motion and to enhance yield of microsphere. CONSTITUTION: A drug-containing polymer microsphere comprises: a hydrophilic part C2-C10 alcohol or polyalkylene glycol; a biodegradable polyester hydrophobic part containing cyclic ester segment and lactide segment; and a drug. A method for manufacturing the microsphere comprises: a step of polymerizing polyalkylene glycol or C2-C10 alcohol with cyclic ester and lactide at 90-150 °C to prepare a polymer having 1,000-100,000 g/mole of molecular weight; a step of adding drug to the polymer; and a step of dispersing drug in an emulsifier to form a microsphere.
Abstract translation: 目的：提供含药聚合物微球及其制造方法，以增强分子运动并提高微球的产量。 构成：含药聚合物微球包含：亲水部分C 2 -C 10醇或聚亚烷基二醇; 含有环酯段和丙交酯链段的可生物降解的聚酯疏水部分; 和一种药物。 微球的制造方法包括：在90-150℃下使环状酯和丙交酯与聚亚烷基二醇或C 2 -C 10醇进行聚合以制备分子量为1,000-100,000g / mol的聚合物的步骤; 向聚合物中加入药物的步骤; 以及将药物分散在乳化剂中以形成微球的步骤。
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3.发明公开
公开(公告)号：KR1020120090709A
公开(公告)日：2012-08-17
申请号：KR1020110011278
申请日：2011-02-08
Applicant: 아주대학교산학협력단
CPC classification number: A61K47/34 , A61K9/0024 , A61K47/593 , A61K47/60 , A61L31/06 , A61L31/14 , A61L31/145 , A61L31/16 , C08G63/664 , C08G63/912 , C08G2261/126 , C08L71/02 , C08L2205/05 , C08G63/08 , A61K47/50 , C08G63/78 , C08G65/48 , C08L67/00 , C08L67/04
Abstract: PURPOSE: A thermo-sensitive polyethylene glycol/polyester block copolymer is provided to easily control thermo-sensitivity by having various functional groups in side chain, and to impart stable drug-dipping performance by deriving interaction with drug. CONSTITUTION: A thermo-sensitive polyethylene glycol/polyester block copolymer comprises lactide segment in which a benzyl ether group is accepted to a side chain, or comprises a hydrophilic portion consisting of polyethylene glycol, and polyester-based hydrophobic portion in which lactide segment is contained into caprolactone segment and side chains. The molar ratio of the caprolactone segment and benzyl ether group-accepted lactide segment is 100:0.01-0.01:100.
Abstract translation: 目的：提供热敏聚乙二醇/聚酯嵌段共聚物以通过在侧链中具有各种官能团来容易地控制热敏感性，并且通过衍生与药物的相互作用来赋予稳定的药物浸渍性能。 构成：热敏聚乙二醇/聚酯嵌段共聚物包含其中苄基醚基团被侧链接受的丙交酯链段，或包含由聚乙二醇组成的亲水部分和其中含有丙交酯链段的聚酯基疏水部分 成为己内酯片段和侧链。 己内酯片段和苄基醚基团接受的丙交酯片段的摩尔比为100：0.01-0.01：100。
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公开(公告)号：KR101270159B1
公开(公告)日：2013-05-31
申请号：KR1020100013109
申请日：2010-02-12
Applicant: 아주대학교산학협력단
IPC: A61K9/16 , A61K47/30 , A61K31/573
Abstract: 본발명은 C~ C의알코올또는분자량이 350 ~ 5,000 g/mole인폴리알킬렌글리콜로구성된친수성부와, 고리형에스터세그먼트와락타이드세그먼트가동시에함유된생분해성폴리에스터계소수성부로구성된중합체에약물이혼입된약물함유고분자미립구및 상기중합체의용융점을제어하여유기용매를적게사용하면서도미립구의수율및 약물의봉입률을증가시킬수 있는상기미립구의제조방법에관한것이다.
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