公开(公告)号：KR1020080114384A

公开(公告)日：2008-12-31

申请号：KR1020070063888

申请日：2007-06-27

Applicant: 아주대학교산학협력단

Inventor： 이영돈 ,  류재하 ,  이달님 ,  조성국 ,  김성수 ,  서해영 ,  이수환

IPC: A61K31/05 ,  A61K36/57 ,  A61P25/28

Abstract: A glycogen synthase kinase-3-beta activity inhibitor including Magnoliae Cortex extracts is provided to prevent GSK-3beta activity excellent and to prevent or treat effectively diseases including a degenerative brain disease and diabetes generated by the activity of the GSK-3beta. A glycogen synthase kinase-3-beta activity inhibitor composition comprises a honokiol or a magnolol as an active ingredient which is derived from Magnoliae Cortex extracts and is used as treating agent for a degenerative brain disease and diabetes.

Abstract translation: 提供了包括玉兰皮质提取物的糖原合酶激酶-3-β活性抑制剂，以防止GSK-3β活性优异，并有效预防或治疗包括由GSK-3β活性产生的退行性脑病和糖尿病的疾病。 糖原合酶激酶-3-β活性抑制剂组合物包含来自Magnoliae Cortex提取物的作为活性成分的厚朴酚或厚朴酚，并用作退行性脑病和糖尿病的治疗剂。