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公开(公告)号：WO2012091449A2
公开(公告)日：2012-07-05
申请号：PCT/KR2011/010221
申请日：2011-12-28
Applicant: 연세대학교 산학협력단 , 이민구 , 김경환 , 지헌영
CPC classification number: A61K38/1709 , C07K14/47 , G01N33/566 , G01N2800/382
Abstract: 본 발명은 인산화된 GRASP(Golgi reassembly stacking protein)을 포함하는 단백질 폴딩이상으로 인한 질병 치료용 약학 조성물에 관한 것이다. 본 발명에 따른 인산화된 GRASP를 포함하는 약학 조성물을 이용하면, 낭포성섬유증의 치료뿐만 아니라 단백질의 폴딩이상으로 인하여 발생되는 질병을 치료할 수 있어 유용하다.
Abstract translation: 本发明涉及用于治疗由蛋白质折叠异常引起的疾病的药物组合物，其包含磷酸化的GRASP（高尔基体重新组装堆积蛋白）。 与药物组合物，其包含根据本发明一个磷酸化的把握，它是有用的，以及治疗囊性纤维化可以治疗由以上所述蛋白质的折叠引起的疾病。
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公开(公告)号：KR100790226B1
公开(公告)日：2008-01-02
申请号：KR1020050105033
申请日：2005-11-03
Applicant: 연세대학교 산학협력단
IPC: C12Q1/68
Abstract: 본 발명은 엑손 및 인트론을 포함하는 MRP2(multidrug resistance associated protein 2) 유전자 및/또는 MRP2 유전자의 전사 시작점을 기준하여 상부(upstream) 5'비번역영역(5'UTR)의 돌연변이를 검출하여 약물 등에 의한 독성 간염 유발 감수성을 검출하는 방법에 관한 것이다.
MRP2, 유전자 변이, 독성 간염, 일배체형, 프로모터-
公开(公告)号：KR1020070048046A
公开(公告)日：2007-05-08
申请号：KR1020050105033
申请日：2005-11-03
Applicant: 연세대학교 산학협력단
IPC: C12Q1/68
Abstract: 본 발명은 엑손 및 인트론을 포함하는 MRP2(multidrug resistance associated protein 2) 유전자 및/또는 MRP2 유전자의 전사 시작점을 기준하여 상부(upstream) 5'비번역영역(5'UTR)의 돌연변이를 검출하여 약물 등에 의한 독성 간염 유발 감수성을 검출하는 방법에 관한 것이다.
MRP2, 유전자 변이, 독성 간염, 일배체형, 프로모터-
公开(公告)号：KR101078876B1
公开(公告)日：2011-11-01
申请号：KR1020090013496
申请日：2009-02-18
Applicant: 연세대학교 산학협력단
Abstract: 개시된측정장치는, 광원; 상기광원으로부터조사된백색광을제1경로로진행하는제1파장광, 제2경로로진행하는제2파장광, 및제3경로로진행하는제3파장광으로분리시키는광 분리유닛; 상기제1파장광, 제2파장광, 제3파장광을동일한경로로진행하도록하는다이크로익프리즘; 상기제1경로상에배치된제1격자; 상기제2경로상에배치된제2격자; 상기제3경로상에배치된제3격자; 및상기다이크로익프리즘을통과한광에의해피검체에형성된격자무늬영상을촬영하는영상감지부를포함하고, 상기제1격자, 제2격자및 제3격자가격자주기가같고, 상기제2격자의격자배열이상기제1격자에비해 1/3 주기만큼쉬프트되고, 상기제3격자의격자배열이상기제2격자에비해 1/3 주기만큼쉬프트되어있다.
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公开(公告)号：KR1020070041164A
公开(公告)日：2007-04-18
申请号：KR1020050097027
申请日：2005-10-14
Applicant: 연세대학교 산학협력단
CPC classification number: C07K14/4712
Abstract: 본 발명은 세포내 알칼리화를 통해 구조적으로 미스폴딩된(misfolded) 단백질의 세포막 발현을 증가시키는 방법에 관한 것이다.
미스폴딩된 단백질, 알칼리화, 소포체, 골지체, 중탄산나드륨(NaHCO3), 바필로마이신 A-
Patent Agency Ranking
公开(公告)号：KR101294725B1
公开(公告)日：2013-08-08
申请号：KR1020100139522
申请日：2010-12-30
Applicant: 연세대학교 산학협력단
CPC classification number: A61K38/1709 , C07K14/47 , G01N33/566 , G01N2800/382
Abstract: 본 발명은 인산화된 GRASP(Golgi reassembly stacking protein)을 포함하는 단백질 폴딩이상으로 인한 질병 치료용 약학 조성물에 관한 것이다. 본 발명에 따른 인산화된 GRASP를 포함하는 약학 조성물을 이용하면, 낭포성섬유증의 치료뿐만 아니라 단백질의 폴딩이상으로 인하여 발생되는 질병을 치료할 수 있어 유용하다.
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公开(公告)号：KR1020100094184A
公开(公告)日：2010-08-26
申请号：KR1020090013496
申请日：2009-02-18
Applicant: 연세대학교 산학협력단
Abstract: PURPOSE: A 3D geometry-measuring apparatus is provided to rapidly measure three dimensional shape of a target by simultaneously processing phase transition. CONSTITUTION: A 3D geometry-measuring apparatus comprises a light source(50), a beam split unit(51), a dichotic prism, a first lattice(61), a second lattice(62), a third lattice(63) and an image sensing unit(80). The beam split unit disunites white light, from the light source, into first wave length light, second wavelength light and third wavelength light. The dichotic prism guides the first wave length light, the second wavelength light, and the third wavelength light to the same route. The first lattice is arranged on the first route. The second lattice is arranged on the second path. The third lattice is arranged on the third route. The image sensing part is formed with the light passing through the dichotic prism in a subject. The image sensing part takes a photograph of the lattice pattern image formed in the subject. The beam split unit comprises a first dichotic filter, a second dichotic filter and a third dichotic filter.
Abstract translation: 目的：提供3D几何测量装置，通过同时处理相变来快速测量目标的三维形状。 构成：3D几何测量装置包括光源（50），光束分离单元（51），双折射棱镜，第一格子（61），第二格子（62），第三格子（63）和 图像感测单元（80）。 光束分离单元将来自光源的白光分为第一波长光，第二波长光和第三波长光。 双折射棱镜将第一波长光，第二波长光和第三波长光引导到相同的路线。 第一个格子排列在第一个路线上。 第二格子布置在第二路径上。 第三个格子排列在第三个路线上。 图像感测部分形成有通过被摄体中的双焦棱镜的光。 图像感测部拍摄在被摄体中形成的格子图案图像的照片。 光束分离单元包括第一透光滤光器，第二透光滤光片和第三双色滤光片。
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公开(公告)号：KR1020120077533A
公开(公告)日：2012-07-10
申请号：KR1020100139522
申请日：2010-12-30
Applicant: 연세대학교 산학협력단
CPC classification number: A61K38/1709 , C07K14/47 , G01N33/566 , G01N2800/382
Abstract: PURPOSE: A pharmaceutical composition containing phosphorylated GRASP is provided to treat diseases caused by abnormal protein folding as well as cystic fibrosis. CONSTITUTION: A pharmaceutical composition for treating cystic fibrosis contains phosphorylated GRASP(Golgi reassembly stacking protein) and pharmaceutically acceptable carrier. The GRASP is denoted by sequence number 1 or 2. The phosphorylated GRASP recovers misfolding CFTR. A method for screening an agent for treating diseases caused by protein misfolding comprises: a step of contacting a sample with cell containing the phosphorylated GRASP protein; a step of measuring the amount or activity of the protein; and a step of determining the sample is the agent in case the protein amount or activity is up regulated.
Abstract translation: 目的：提供含有磷酸化GRASP的药物组合物，用于治疗异常蛋白质折叠以及囊性纤维化引起的疾病。 构成：用于治疗囊性纤维化的药物组合物含有磷酸化GRASP（高尔基体重组蛋白）和药学上可接受的载体。 GRASP由序列号1或2表示。磷酸化GRASP恢复错误折叠CFTR。 用于筛选用于治疗由蛋白质错误折叠引起的疾病的药剂的方法包括：使样品与含有磷酸化GRASP蛋白的细胞接触的步骤; 测量蛋白质的量或活性的步骤; 并且确定样品的步骤是在蛋白质量或活性被调节的情况下的试剂。
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公开(公告)号：KR1020100094185A
公开(公告)日：2010-08-26
申请号：KR1020090013497
申请日：2009-02-18
Applicant: 연세대학교 산학협력단
Abstract: PURPOSE: A 3D geometry-measuring apparatus is provided to precisely measure a three dimensional shape without physical operation. CONSTITUTION: A 3D geometry-measuring apparatus comprises a light source(50), a beam split unit(57), a first lattice(64), a second lattice(72), a third lattice(84), a fourth lattice(90), a light synthesizing unit(65) and an image sensing unit. The first lattice is arranged on the first route. The second lattice is arranged on the second path. The third lattice is arranged on the third route. The fourth lattice is arranged on the fourth route. The photosynthetic unit guides first wave length light, second wavelength light, third wavelength light and fourth wavelength light to the same route. The image sensing unit takes a lattice pattern image.
Abstract translation: 目的：提供3D几何测量装置，以精确测量三维形状而不进行物理操作。 构造：3D几何测量装置包括光源（50），光束分离单元（57），第一晶格（64），第二晶格（72），第三晶格（84），第四晶格（90 ），光合成单元（65）和图像感测单元。 第一个格子排列在第一个路线上。 第二格子布置在第二路径上。 第三个格子排列在第三个路线上。 第四个格子被布置在第四个路线上。 光合单元将第一波长光，第二波长光，第三波长光和第四波长光引导到相同的路线。 图像感测单元获取格子图案图像。
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公开(公告)号：KR100818126B1
公开(公告)日：2008-03-31
申请号：KR1020070019909
申请日：2007-02-27
Applicant: 연세대학교 산학협력단
CPC classification number: G06K19/0614 , B82Y20/00 , G06K1/123 , G06K7/10722 , G06K7/1408 , G06K2019/06225
Abstract: A color barcode using nano-rods and a detecting system thereof are provided to increase the quantity of information included in a barcode by adding a color code to the nano-rods, which irradiate light having a unique wavelength by resonating with visible light, and expand an application area of the barcode by minimizing the size of the barcode with the nano-rods. Multiple nano-rods have a size by nanometer and generate surface plasmon resonance caused by light reception. A barcode(210) includes at least two nano-rods irradiating the light of the different wavelength by the surface plasmon resonance according to each material. A light source(200) irradiates the light, and the barcode is put on a stage, and a polarizer(203) is placed between the light source and the stage. A spectroscope(240) generates an absorption spectrum of the light output after the surface plasmon resonance generated from the nano-rods receiving the light irradiated from the light source. A CCD(Charge Coupled Device)(230) captures a barcode image, and a color filter(220) is placed between the stage and the CCD.
Abstract translation: 提供使用纳米棒的彩色条形码及其检测系统，以通过向通过与可见光共振来照射具有独特波长的光的纳米棒添加色码来增加条形码中包含的信息量，并且扩展 通过使用纳米棒来最小化条形码的大小来使条形码的应用区域。 多个纳米棒具有纳米尺寸并产生由光接收引起的表面等离子体共振。 条形码（210）包括根据每种材料通过表面等离子体共振照射不同波长的光的至少两个纳米棒。 光源（200）照射光，将条形码放在台上，偏光镜（203）置于光源与台之间。 分光器（240）在从接收从光源照射的光的纳米棒产生的表面等离子体共振之后产生光输出的吸收光谱。 CCD（电荷耦合器件）（230）捕获条形码图像，并且滤色器（220）放置在平台和CCD之间。
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