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    신규한 커큐민 유도체
    2.
    发明公开
    신규한 커큐민 유도체 失效
    新型CURCUMIN衍生物和包含其的抗神经药物组合物

    公开(公告)号：KR1020050010058A

    公开(公告)日：2005-01-26

    申请号：KR1020047020459

    申请日：2002-06-17

    Applicant: 연세대학교 산학협력단

    Inventor： 권호정 ,  심중섭 ,  김진희 ,  최승훈 ,  신종헌 ,  노정래

    IPC: C07C49/248 ,  C07C251/40

    Abstract: PURPOSE: Provided are a novel curcumin derivative having anti-angiogenesis activity and a pharmaceutical composition for preventing or treating unregulated angiogenesis-related diseases, comprising the same as an effective ingredient. CONSTITUTION: The curcumin derivative is represented by the formula I, wherein each of R1 and R4 is H or a C1-C4 alkyl group, each of R2 and R3 is H or a C1-C4 alkoxy group, each of R5 and R6 is nitrogen atom or oxygen atom; in case that both of R5 and R6 are nitrogen atoms, each of R5 and R6 is substituted by OR7(in which, R7 is hydrogen, an alkyl, a cycloalkyl, an aryl, an alkaryl, or an aralkyl) or R5 and R6 form a hydrazine group-containing ring, and R5 and R6 may be non-substituted or independently substituted by an alkyl, a cycloalkyl, an aryl, an alkaryl or an aralkyl; in case that R1 is H, R2 is not methoxy group, R3 is not hydrogen or methoxy group, R4 is not hydrogen, and R5 and R6 are not oxygen. The pharmaceutical composition for preventing or treating unregulated angiogenesis-related diseases comprises an effective amount of the curcumin derivative together with a pharmaceutical acceptable carrier.

    Abstract translation: 目的：提供一种具有抗血管生成活性的新型姜黄素衍生物和用于预防或治疗未调节血管生成相关疾病的药物组合物，其包含其作为有效成分。 构成：姜黄素衍生物由式I表示，其中R 1和R 4各自为H或C 1 -C 4烷基，R 2和R 3各自为H或C 1 -C 4烷氧基，R 5和R 6各自为氮 原子或氧原子; 在R 5和R 6都是氮原子的情况下，R 5和R 6各自被OR 7取代（其中R 7是氢，烷​​基，环烷基，芳基，烷芳基或芳烷基）或R 5和R 6形式 含肼基的环，R 5和R 6可以被烷基，环烷基，芳基，烷芳基或芳烷基取代或独立地取代; 在R1是H的情况下，R2不是甲氧基，R3不是氢或甲氧基，R4不是氢，R5和R6不是氧。 用于预防或治疗未调节血管生成相关疾病的药物组合物包括有效量的姜黄素衍生物和药学上可接受的载体。

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