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公开(公告)号：KR100275039B1
公开(公告)日：2000-12-15
申请号：KR1019980046559
申请日：1998-10-31
Applicant: 우리켐테크(주)
IPC: C07C49/607
Abstract: 본 발명은 천연사향의 방향성분인 무스콘의 합성에 유용한 중간체인 시클로펜타덱-2-에논의 제조방법에 관한 것으로, 본 발명의 방법은 (a) 촉매량의 산존재하에 시클로펜타데카논에 디페닐셀레나이드와 셀레늄디옥사이드를 반응시켜 2-페닐셀레닐시클로펜타데카논을 생성하는 단계와, (b) 2-페닐셀레닐시클로펜타데카논을 염기의 존재하에서 산화제와 반응시켜 목적화합물인 시클로펜타덱-2-에논을 생성하는 단계로 이루어진다.
본 발명의 방법에 의하면, 간단한 2단계 공정에 의해 분리,정제공정없이도 고순도의 시클로펜타덱-2-에논을 고수율로 제조할 수 있다.-
Patent Agency Ranking2.发明授权남성 생식기능 저하에 대한 예방 및 치료효과를 지닌 천연페놀 및 폴리페놀계 화합물을 포함하는 약제학적 조성물 失效包含天然酚和多酚的药物组合物，用于保护男性生殖系统免受内分泌干扰物诱导的损伤
公开(公告)号：KR100340763B1
公开(公告)日：2002-06-20
申请号：KR1019990040571
申请日：1999-09-21
Applicant: 우리켐테크(주)
Abstract: 본발명은다이옥신등 내분비교란물질(일명환경호르몬)에의한사람을포함한각종동물에있어서의정자수감소, 정자의운동능의저하등과같은각종남성생식기능저하에대한예방및 치료효과를지닌천연페놀및 폴리페놀계화합물의새로운용도및 이러한용도를갖는천연페놀및 폴리페놀을포함하는약제학적조성물에관한것이다. 본발명의천연페놀및 폴리페놀은사과, 배, 복숭아등과같은장미과식물의과실(미숙과포함), 커피두, 카카오두, 포도씨등으로부터얻어지기때문에인체에무해하다.
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公开(公告)号：KR100340761B1
公开(公告)日：2002-06-20
申请号：KR1020000024819
申请日：2000-05-10
Applicant: 우리켐테크(주)
IPC: C07B63/02
Abstract: 본 발명은 3-메칠 시클로펜타데칸-1-온(Ⅱ)에 트레이톨 유도체들을 반응하여
dl -무스콘 케탈 화합물(Ⅲ)을 만든 후 이를 가수분해하여
l -무스콘(I)을 분리 정제하는 방법에 있어서, 순상 크로마토그래피 조건 하에서
dl -무스콘 케탈 화합물(Ⅲ)을 분취한 후 이를 가수분해하여 입체선택적으로
l -무스콘(I)을 분리 정제하는 방법을 제공하는 것이다.
(반응식 1)
상기식에서 R
1 은 아래 구조식의 관능기를 나타낸다.-
4.发明公开
公开(公告)号：KR1020010028366A
公开(公告)日：2001-04-06
申请号：KR1019990040571
申请日：1999-09-21
Applicant: 우리켐테크(주)
Abstract: PURPOSE: Provided are natural phenol and polyphenol compounds which have prevention and treatment effects on male dysgenesia by inactivating endocrine disruptors, such as dioxin, that cause male dysgenesia. And methods for extracting and purifying natural phenol and polyphenol compounds and a pharmaceutical composition containing them are also provided . CONSTITUTION: Natural phenol and polyphenol are prepared by using fruits of the family Rosaceae such as apple, peach, pear, and coffee bean, cacao bean and grape seed. A first method of using an apple is characterized by the next steps: i) compressing a clean apple to obtain juice and treating the juice with pectinase; ii) adsorbing filtered juice into columns and cleansing the juice; iii) obtaining condensed solution with 65% ethanol and drying the solution to obtain powdered extract of an apple. A second method of using coffee comprises the steps: i) grinding coffee bean into the size of 5 mm and eliminating foreign substances; and ii) extracting condensed coffee solution with deionized water and drying the solution to obtain powdered coffee extracts. A third method of using cacao bean includes the steps: i) extracting solution from dried cacao beans or their skins with 60% acetone for 24 hours; ii) centrifuging the obtained solution and obtaining supernatant and remnants; iii) adding acetone to the remnants again and repeating the extraction processes four times; iv) condensing and filtering the supernatant and removing chlorophyll from the supernatant; and v) obtaining cacao extracts by using acetone.
Abstract translation: 目的：提供天然苯酚和多酚化合物，通过灭活导致男性发病不良的内分泌干扰物（如二恶英），对男性发病不良有预防和治疗的作用。 还提供了提取和提纯天然酚和多酚化合物的方法和含有它们的药物组合物。 构成：使用苹果，桃，梨，咖啡豆，可可豆和葡萄籽等蔷薇科的果实制备天然酚和多酚。 使用苹果的第一种方法的特征在于以下步骤：i）压缩干净的苹果以获得果汁并用果胶酶处理果汁; ii）将过滤的果汁吸入柱子中并清洗果汁; iii）用65％乙醇获得冷凝溶液并干燥该溶液，得到苹果粉末状提取物。 使用咖啡的第二种方法包括以下步骤：i）将咖啡豆研磨成5mm的尺寸并除去异物; 和ii）用去离子水萃取浓缩咖啡溶液并干燥该溶液以获得粉状咖啡提取物。 使用可可豆的第三种方法包括以下步骤：i）用60％丙酮从干燥的可可豆或其皮肤中提取溶液24小时; ii）离心所得溶液并获得上清液和残留物; iii）再次向剩余物中加入丙酮，重复萃取过程四次; iv）冷凝和过滤上清液并从上清液中除去叶绿素; 和v）通过使用丙酮获得可可提取物。
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公开(公告)号：KR1020000049980A
公开(公告)日：2000-08-05
申请号：KR1020000024819
申请日：2000-05-10
Applicant: 우리켐테크(주)
IPC: C07B63/02
Abstract: PURPOSE: A stereo-selective method for separating l-muscone is provided which is an effective method for preparing the l-muscone with high purity and high yield. CONSTITUTION: A method for separating l-muscone comprises the steps of: (i) reacting 3-methylcyclopentadecan-1-one of the following formula (II) with a threitol derivative under the condition of current phase chromatography to prepare dl-muscone ketal compound of the following formula (III); and (ii) hydrolyzing the prepared dl-muscone ketal compound to separate the l-muscone of the following formula (I).
Abstract translation: 目的：提供一种立体选择性分离L-肌醇的方法，该方法是制备高纯度和高产率的L-肌醇的有效方法。 构成：分离L-肌醇的方法包括以下步骤：（i）在目前的相色谱条件下，使下式（II）的3-甲基环十五烷-1-酮与苏糖醇衍生物反应以制备dl-肌醇缩酮化合物 的下式（III）; 和（ii）水解制备的dl-肌醇缩酮化合物以分离下式（I）的l-肌醇。
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公开(公告)号：KR1020000028355A
公开(公告)日：2000-05-25
申请号：KR1019980046559
申请日：1998-10-31
Applicant: 우리켐테크(주)
IPC: C07C49/607
Abstract: PURPOSE: A process for producing cyclopentadec-2-enone as a useful intermediate for the synthesis of muscone as an aromatic component of natural musk is provided which can produce the title compound in high purity and yield without purification processes. CONSTITUTION: A process comprises the steps of (a) producing 2-phenyl selenyl cyclopentadecanone by reacting cyclopentadecanone with diphenylselenide and selenium dioxide in the presence of an acid and (b) producing cyclopentadec-2-enone by reacting 2-phenyl selenyl cyclopentadecanone with an oxidant in the presence of a base. The acid is a Lewis acid such as sulfuric acid or trifluoroboron.diethylether(BF3.OEt2), the oxidant is hydrogen peroxide, peroxybenzoate, methachloroperbenzoic acid or oxone and the base is pyridine or imidazole.
Abstract translation: 目的：提供一种生产环戊十烯-2-酮作为天然麝香的芳族成分的肌醇合成有用中间体的方法，可以无需纯化即可生产高纯度和无收率的标题化合物。 构成：一种方法包括以下步骤：（a）在酸存在下使环十五烷酮与二苯基硒和二氧化硒反应制备2-苯基烯丙基环十五烷，和（b）通过2-苯基烯丙基环十五烷与 氧化剂在碱的存在下。 酸是路易斯酸如硫酸或三氟硼烷二乙醚（BF 3 OEt 2），氧化剂是过氧化氢，过氧苯甲酸酯，甲基氯过苯甲酸或丁酮，碱是吡啶或咪唑。
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