公开(公告)号：KR100340763B1

公开(公告)日：2002-06-20

申请号：KR1019990040571

申请日：1999-09-21

Applicant: 우리켐테크(주)

Inventor： 김권 ,  이학수 ,  정세영 ,  이승용 ,  박무신

IPC: A61K36/73 ,  A61P15/00

Abstract: 본발명은다이옥신등 내분비교란물질(일명환경호르몬)에의한사람을포함한각종동물에있어서의정자수감소, 정자의운동능의저하등과같은각종남성생식기능저하에대한예방및 치료효과를지닌천연페놀및 폴리페놀계화합물의새로운용도및 이러한용도를갖는천연페놀및 폴리페놀을포함하는약제학적조성물에관한것이다. 본발명의천연페놀및 폴리페놀은사과, 배, 복숭아등과같은장미과식물의과실(미숙과포함), 커피두, 카카오두, 포도씨등으로부터얻어지기때문에인체에무해하다.

公开(公告)号：KR1020010028366A

公开(公告)日：2001-04-06

申请号：KR1019990040571

申请日：1999-09-21

Applicant: 우리켐테크(주)

Inventor： 김권 ,  이학수 ,  정세영 ,  이승용 ,  박무신

IPC: A61K36/73 ,  A61P15/00

Abstract: PURPOSE: Provided are natural phenol and polyphenol compounds which have prevention and treatment effects on male dysgenesia by inactivating endocrine disruptors, such as dioxin, that cause male dysgenesia. And methods for extracting and purifying natural phenol and polyphenol compounds and a pharmaceutical composition containing them are also provided . CONSTITUTION: Natural phenol and polyphenol are prepared by using fruits of the family Rosaceae such as apple, peach, pear, and coffee bean, cacao bean and grape seed. A first method of using an apple is characterized by the next steps: i) compressing a clean apple to obtain juice and treating the juice with pectinase; ii) adsorbing filtered juice into columns and cleansing the juice; iii) obtaining condensed solution with 65% ethanol and drying the solution to obtain powdered extract of an apple. A second method of using coffee comprises the steps: i) grinding coffee bean into the size of 5 mm and eliminating foreign substances; and ii) extracting condensed coffee solution with deionized water and drying the solution to obtain powdered coffee extracts. A third method of using cacao bean includes the steps: i) extracting solution from dried cacao beans or their skins with 60% acetone for 24 hours; ii) centrifuging the obtained solution and obtaining supernatant and remnants; iii) adding acetone to the remnants again and repeating the extraction processes four times; iv) condensing and filtering the supernatant and removing chlorophyll from the supernatant; and v) obtaining cacao extracts by using acetone.

Abstract translation: 目的：提供天然苯酚和多酚化合物，通过灭活导致男性发病不良的内分泌干扰物（如二恶英），对男性发病不良有预防和治疗的作用。 还提供了提取和提纯天然酚和多酚化合物的方法和含有它们的药物组合物。 构成：使用苹果，桃，梨，咖啡豆，可可豆和葡萄籽等蔷薇科的果实制备天然酚和多酚。 使用苹果的第一种方法的特征在于以下步骤：i）压缩干净的苹果以获得果汁并用果胶酶处理果汁; ii）将过滤的果汁吸入柱子中并清洗果汁; iii）用65％乙醇获得冷凝溶液并干燥该溶液，得到苹果粉末状提取物。 使用咖啡的第二种方法包括以下步骤：i）将咖啡豆研磨成5mm的尺寸并除去异物; 和ii）用去离子水萃取浓缩咖啡溶液并干燥该溶液以获得粉状咖啡提取物。 使用可可豆的第三种方法包括以下步骤：i）用60％丙酮从干燥的可可豆或其皮肤中提取溶液24小时; ii）离心所得溶液并获得上清液和残留物; iii）再次向剩余物中加入丙酮，重复萃取过程四次; iv）冷凝和过滤上清液并从上清液中除去叶绿素; 和v）通过使用丙酮获得可可提取物。