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公开(公告)号：KR100403051B1
公开(公告)日：2003-10-23
申请号：KR1020000042901
申请日：2000-07-25
Applicant: 일양약품주식회사
IPC: A61K31/568 , A61K9/70
Abstract: PURPOSE: A composition of matrix type patch for transdermal testosterone delivery and a process for preparing the same are provided, therefore the patch can be easily attached on the skin and testosterone is delivered rapidly. CONSTITUTION: The composition contains 2 to 8 wt.% of testosterone or its salts, 25 to 80 wt.% of cohesive polymers, 5 to 15 wt.% of surfactant, 2 to 5 wt.% of melting supplement and 1 to 5 wt.% of absorption promoter, in which the salt of testosterone is testosterone propionate; the cohesive polymer is alkylacrylate or methacrylate; the surfactant is sorbitan monooleate; the melting supplement is selected from propyleneglycol monolaurate, diethyltoluamide, dimethylsulfoxide, poloxamer, N-methylpyrrolidone, cremophor, labrafil, caprylocaproyl macrogol-8-glyceride, hardening castor oil, Gelucire, macrogol-15-hydroxystearate and the mixture thereof. The patch for transdermal testosterone delivery can be monolithic type or laminated type of a reservoir layer.
Abstract translation: 目的：提供了用于经皮睾酮递送的基质型贴剂组合物及其制备方法，因此贴剂可以容易地附着在皮肤上并且睾酮迅速递送。 组成：该组合物含有2至8重量％的睾酮或其盐，25至80重量％的粘性聚合物，5至15重量％的表面活性剂，2至5重量％的熔化添加剂和1至5重量％ ％的吸收促进剂，其中睾酮盐是丙酸睾酮; 粘性聚合物是丙烯酸烷基酯或甲基丙烯酸烷基酯; 表面活性剂是失水山梨糖醇单油酸酯; 所述熔融添加剂选自丙二醇单月桂酸酯，二乙基甲苯酰胺，二甲基亚砜，泊洛沙姆，N-甲基吡咯烷酮，克列莫佛，labrafil，辛酰己酰聚乙二醇-8-甘油酯，硬化蓖麻油，Gelucire，聚乙二醇-15-羟基硬脂酸酯及其混合物。 用于透皮睾酮递送的贴剂可以是整体型或层压型储库层。
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公开(公告)号：KR1020010010664A
公开(公告)日：2001-02-15
申请号：KR1019990029673
申请日：1999-07-21
Applicant: 일양약품주식회사
IPC: A61K9/70
CPC classification number: A61K9/7046 , A61K31/135 , A61K47/12
Abstract: PURPOSE: A plasta composition(a kind of subcutaneous administration system) for soothing itch is provided, which shows good adhesiveness and high absorption rate, is easy to separate, and solves problems of the secondary infection, stickiness of existing skin-administrating preparation. CONSTITUTION: A process for the preparation of plasta composition for soothing itch comprises the steps of: mixing and dissolving diphenhydramine(anti-histamine agent), dibucaine-HCl, and capric acid(absorption-promoting agent) in N-methylpyrolidone; adding the mixed solution into butylacrylate copolymer high-molecular solution(AS-594; a kind of adhesive agents); adding ethylacetate(dissolving adjuvant), mixing for 25minutes, and leaving for 20minutes to remove bubbles; spreading the mixture on a thin sheet in 50-150μ thick, and drying for 5minutes at 80deg.C to prepare drug-reservoir layer(the drug-reservoir layer can be prepared in the form of multi-layer structure); and applying a plastic film on the layer, and cutting into 3.14cm2 size to get the final product.
Abstract translation: 目的：提供舒缓瘙痒的plasta组合物（一种皮下给药系统），具有良好的粘附性和高吸收率，容易分离，并解决了二次感染，现有皮肤给药制剂的粘性问题。 构成：用于制备用于舒缓瘙痒的塑性组合物的方法包括以下步骤：将苯海拉明（抗组胺剂），地布卡宁-HCl和癸酸（吸收促进剂）混合并溶解在N-甲基吡咯烷酮中; 将混合溶液加入到丙烯酸丁酯共聚物高分子溶液（AS-594;一种粘合剂）中; 加入乙酸乙酯（溶解佐剂），混合25分钟，并留下20分钟以除去气泡; 将混合物铺在50-150μ厚的薄片上，在80℃下干燥5分钟，制备药物储层（药层可以以多层结构的形式制备）; 并在该层上涂一层塑料薄膜，切成3.14cm2尺寸以得到最终产品。
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公开(公告)号：KR1020000024702A
公开(公告)日：2000-05-06
申请号：KR1019980041351
申请日：1998-10-01
Applicant: 일양약품주식회사
IPC: A61K9/70
CPC classification number: A61K9/7084 , A61K9/7092 , A61K31/192
Abstract: PURPOSE: A pasting agent containing anti-inflammatory analgesics composition like as Loxoprofen or its salts is provided, which makes prescription effect to be maximum by applying the effective medicine to the skin without causing gastroenteric trouble or peptic ulcer. The cata plasma also can release effective composition like as Loxoprofen or its salts continuously in a fixed amount. CONSTITUTION: A pasting agent containing anti-inflammatory analgesics composition comprises of 0.5-25wt.% of Loxoprofen or its salts, 25-80wt.% of adhesive polymer, 8-70wt.% of dissolving supplemental agent and 0.5-15wt.% of absorption accelerator. The pasting agent containing anti-inflammatory analgesics composition consists of a supporter(1), a removable layer(2) and single of multi layer(3) containing medicine in it.
Abstract translation: 目的：提供含有洛索洛芬或其盐类抗炎止痛剂组合物的粘贴剂，通过将有效药物施用于皮肤而不引起胃肠道疾病或消化性溃疡，使处方效果最大化。 气相等离子体还可以以固定的量连续释放如洛索丙芬或其盐类的有效组合物。 构成：含有消炎止痛剂组合物的糊剂包含0.5-25wt％的洛索丙芬或其盐，25-80wt。％的粘合剂聚合物，8-70wt。％的溶解补充剂和0.5-15wt。％的吸收 加速器。 含有消炎止痛剂组合物的糊剂由其中含有药物的支持体（1），可除去层（2）和单层多层（3）组成。
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Patent Agency Ranking
公开(公告)号：KR1020020008730A
公开(公告)日：2002-01-31
申请号：KR1020000042901
申请日：2000-07-25
Applicant: 일양약품주식회사
IPC: A61K31/568 , A61K9/70
Abstract: PURPOSE: A composition of matrix type patch for transdermal testosterone delivery and a process for preparing the same are provided, therefore the patch can be easily attached on the skin and testosterone is delivered rapidly. CONSTITUTION: The composition contains 2 to 8 wt.% of testosterone or its salts, 25 to 80 wt.% of cohesive polymers, 5 to 15 wt.% of surfactant, 2 to 5 wt.% of melting supplement and 1 to 5 wt.% of absorption promoter, in which the salt of testosterone is testosterone propionate; the cohesive polymer is alkylacrylate or methacrylate; the surfactant is sorbitan monooleate; the melting supplement is selected from propyleneglycol monolaurate, diethyltoluamide, dimethylsulfoxide, poloxamer, N-methylpyrrolidone, cremophor, labrafil, caprylocaproyl macrogol-8-glyceride, hardening castor oil, Gelucire, macrogol-15-hydroxystearate and the mixture thereof. The patch for transdermal testosterone delivery can be monolithic type or laminated type of a reservoir layer.
Abstract translation: 目的：提供用于透皮睾丸激素递送的基质型贴剂的组合物及其制备方法，因此贴剂可以容易地附着在皮肤上，迅速递送睾丸激素。 组成：组合物含有2至8重量％的睾酮或其盐，25至80重量％的粘合聚合物，5至15重量％的表面活性剂，2至5重量％的熔融补充剂和1至5重量％ 吸收促进剂的％，其中睾酮的盐是丙酸睾酮; 内聚聚合物是丙烯酸烷基酯或甲基丙烯酸烷基酯; 表面活性剂是脱水山梨糖醇单油酸酯; 熔融补充剂选自丙二醇单月桂酸酯，二乙基甲酰胺，二甲基亚砜，泊洛沙姆，N-甲基吡咯烷酮，cremophor，labrafil，辛酰己内酰甘油-8-甘油酯，硬化蓖麻油，Gelucire，聚乙炔-15-羟基硬脂酸酯及其混合物。 用于透皮睾丸激素递送的贴剂可以是整体型或层压型储层。
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公开(公告)号：KR1019990064549A
公开(公告)日：1999-08-05
申请号：KR1019990012419
申请日：1999-04-08
Applicant: 일양약품주식회사
IPC: A61K9/70
CPC classification number: A61K9/7061 , A61F7/02 , A61F2007/0204 , A61K31/192 , A61K31/433
Abstract: 본발명은철과공기의산화작용을이용하여자발적으로발열하는발열체가첨부된자기발열성경피투여형제제를이용한첩부제에관한것이다. 본발명에따라자기발열첩부제를사용하게되면종래의흡수촉진제를사용해서주약의경피흡수를촉진함에따른피부손상및 흡수촉진제의전신순환에의한부작용등의단점을보완한국소에열을적용하여확산계수의증가및 혈액순환촉진에의한유효약물의흡수를촉진시킬수 있다.
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公开(公告)号：KR1020020096440A
公开(公告)日：2002-12-31
申请号：KR1020010034884
申请日：2001-06-20
Applicant: 일양약품주식회사
IPC: A61K9/16
CPC classification number: A61K9/5036 , A61K9/1617 , A61K31/435
Abstract: PURPOSE: A process of preparing an apomorphine formulation for oral use by granulation of apomorphine, spraying a coating liquid at low temperature and spraying the coating liquid at high speed while floating the coating liquid at low temperature is provided. Whereby, the formulation is excellent in treatment of erectile dysfunction. CONSTITUTION: An excipient, binder and solvent are added to a mixed powder containing 1 to 10% by weight of apomorphine or acid salts thereof, 20 to 40% by weight of ascorbic acid, 10 to 20% by weight of domperidone to produce apomorphine granules. A coating liquid comprising 1 to 30% by weight of a coating base, 0.1 to 1.0% by weight of a plasticizer and a solvent is coated on 30 to 40% by weight of the granules at 30 to 40deg.C to produce first coated granules. A coating liquid comprising 1 to 30% by weight of a coating base and 0.1 to 1.0% by weight of a plasticizer is coated on 30 to 40% by weight of the first coated granules at 30 to 40deg.C to produce second coated granules. Thereafter, 40 to 50% by weight of apomorphine, 20 to 30% by weight of the first coated granules and 30% by weight of the second coated granules are mixed.
Abstract translation: 目的：提供阿朴吗啡口服制剂的制备方法，通过造粒阿扑吗啡，在低温下喷涂涂液，并在低温下漂浮涂液时高速喷涂涂布液。 因此，该制剂在勃起功能障碍的治疗中是优异的。 构成：将赋形剂，粘合剂和溶剂加入到含有1-10重量％的阿朴吗啡或其酸盐，20-40重量％的抗坏血酸，10-20重量％的多潘立酮的混合粉末中以产生阿扑吗啡颗粒 。 在30〜40℃下，在30〜40重量％的颗粒中涂布1〜30重量％的涂布基质，0.1〜1.0重量％的增塑剂和溶剂的涂布液，制成第1包衣颗粒 。 在30至40℃下，将30至40重量％的第一包衣颗粒涂覆包含1至30重量％的涂层基质和0.1至1.0重量％的增塑剂的涂布液，以制备第二涂布颗粒。 然后，混合40〜50重量％的阿扑吗啡，20〜30重量％的第一包衣颗粒和30重量％的第二包衣颗粒。
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公开(公告)号：KR100322988B1
公开(公告)日：2002-11-01
申请号：KR1019980041351
申请日：1998-10-01
Applicant: 일양약품주식회사
IPC: A61K9/70
Abstract: 본 발명은 록소프로펜 또는 그의 염을 유효성분으로 함유한 소염진통 첩부제 조성물 및 이 조성물을 함유한 약물저장층, 이 저장층상에 첩부된 비투과성 지지체 및 이 저장층 밑에 부착된 박리층으로 구성된 소염진통 첩부제에 관한 것이다.
본 발명에 따라 록소프로펜 또는 그의 염을 경피투여제제에 사용하게 되면 위장장해나 소화성궤양등과 같은 부작용을 일으키지 않고 간편하게 피부에 부착시켜서 유효약물을 경피투여함으로써 그 투여효과를 극대화할 수 있으며, 소화관벽과 간대사 및 위장관내 반응을 피할 수 있다. 또한 본 발명의 소염진통 첩부제는 록소프로펜 또는 그의 염과 같은 유효물질을 지속적으로 일정하게 투여할 수 있다. -
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