公开(公告)号：KR101076717B1

公开(公告)日：2011-10-26

申请号：KR1020080110187

申请日：2008-11-07

Applicant: 재단법인대구경북과학기술원

Inventor： 이세근 ,  이성준 ,  정상원 ,  김현철 ,  장병욱 ,  최재홍 ,  박재형 ,  염정현

IPC: B82B1/00 ,  B82B3/00 ,  B82Y5/00

Abstract: 티타니아(TiO) 나노입자및 상기티타니아나노입자표면에흡착된광감작제를포함하는광역학치료용나노구조체와그 제조방법이제공된다. 상기광역학치료용나노구조체는중성수용액조건에서분산안정성이우수하며단일항산소발생효율이높다.

公开(公告)号：KR1020100051163A

公开(公告)日：2010-05-17

申请号：KR1020080110187

申请日：2008-11-07

Applicant: 재단법인대구경북과학기술원

Inventor： 이세근 ,  이성준 ,  정상원 ,  김현철 ,  장병욱 ,  최재홍 ,  박재형 ,  염정현

IPC: B82B1/00 ,  B82B3/00 ,  B82Y5/00

Abstract: PURPOSE: A method for manufacturing a nanostructure for photodynamic therapy is provided to ensure dispersion stability and generation efficiency of singlet oxygen. CONSTITUTION: A nanostructure for photodynamic therapy contains titania(TiO_2) nanoparticles and photosensitizer adsorbed on the surface of titania nanoparticle. A polymer dispersing agent is adsorbed on the surface of titania nanoparticles. The polymer dispersing agent is selected from polymethacrylic acid sodium salt, glycol chitosan, polyvinyl alcohol, polyethyleneimine, and polyethylene glycol. The photosensitizer is a phthalocyanine derivative containing copper phthalocyanine, zinc phthalocyanine, and aluminum phthalocyanine, and a porphyrin derivative containing protoporphyrin IX, aminolevulinic acid, and hematoporphyrin. A method for manufacturing the nanostructure comprises: a step of preparing titania sol; a step of inputting polymer dispersing agent to the titania sol to adsorb on the titania surface; and a step of inputting the photosensitizer to titania sol.

Abstract translation: 目的：提供一种用于制造光动力学治疗纳米结构的方法，以确保单线态氧的分散稳定性和发生效率。 构成：用于光动力学治疗的纳米结构包含二氧化钛（TiO_2）纳米颗粒和吸附在二氧化钛纳米颗粒表面上的光敏剂。 聚合物分散剂被吸附在二氧化钛纳米颗粒的表面上。 聚合物分散剂选自聚甲基丙烯酸钠盐，乙二醇壳聚糖，聚乙烯醇，聚乙烯亚胺和聚乙二醇。 光敏剂是含有酞菁铜，酞菁锌和铝酞菁的酞菁衍生物和含有原卟啉IX，氨基乙酰丙酸和血卟啉的卟啉衍生物。 制造纳米结构体的方法包括：制备二氧化钛溶胶的步骤; 将聚合物分散剂输入到二氧化钛溶胶中以吸附在二氧化钛表面上的步骤; 以及将光敏剂输入二氧化钛溶胶的步骤。