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公开(公告)号：KR101024702B1
公开(公告)日：2011-03-25
申请号：KR1020080071619
申请日：2008-07-23
Applicant: 재단법인서울대학교산학협력재단
Abstract: 본 발명은
in
vitro 파지 디스플레이 기법에 의해 선발되어 암세포 표면에 발현되는 수용체를 표적할 수 있는 저분자 결합 유도 펩타이드에 관한 것으로, 본 발명에 따른 펩타이드는 암세포의 표적 및 결합 능력을 획기적으로 증진시킨 효율적인 투약 시스템에 효과적으로 이용될 수 있다.
수용체 리간드 상호작용, 암세포 표적물질, 파지 디스플레이, 세포 특이적 결합 펩타이드-
公开(公告)号：KR1020100010645A
公开(公告)日：2010-02-02
申请号：KR1020080071619
申请日：2008-07-23
Applicant: 재단법인서울대학교산학협력재단
Abstract: PURPOSE: A low molecule-binding induction peptide which is able to target a receptor which is expressed on the surface of cancer cells is provided enhance ability of targeting and binging to cancer cells and use as low molecular peptide drug. CONSTITUTION: A cancer cell-targeting low molecule-binding induction peptide contains one amino acid sequence among sequence numbers 1 to 12. The cancer cell-targeting low molecule-binding induction peptide has amino acid sequence of CTLPHLKMC(sequence number 1), CLYGNSDC(sequence number 2), CQHNHSKQC(sequence number 3), CTKQHTSQC(sequence number 4), CDWTKPQSC(sequence number 5), CNPSLALHC(sequence number 6), CSTGAHTQC(sequence number 7), CTVKNGTLC(sequence number 8), CQEGKMRLC(sequence numb 9), CSEHKTPMC(sequence number 10) CQKQGHPSC(sequence number 11) or CTSTPFRIC(sequence number 12). A receptor of the peptide is a variable region of human immunoglobulin heavy chain. The variable region has 75kDa of band. A pharmaceutical composition for cancer cell targeting contains the low molecule binding induction peptide.
Abstract translation: 目的：提供能够靶向在癌细胞表面表达的受体的低分子结合诱导肽增强了靶向和结合癌细胞的能力并用作低分子肽药物。 构成：癌细胞靶向低分子结合诱导肽在序列号1〜12中含有一个氨基酸序列。癌细胞靶向低分子结合诱导肽具有CTLPHLKMC（序列号1），CLYGNSDC（序列号1） 序列号2），CQHNHSKQC（序列号3），CTKQHTSQC（序列号4），CDWTKPQSC（序列号5），CNPSLALHC（序列号6），CSTGAHTQC（序列号7），CTVKNGTLC（序列号8），CQEGKMRLC 麻醉9），CSEHKTPMC（序列号10）CQKQGHPSC（序列号11）或CTSTPFRIC（序列号12）。 肽的受体是人免疫球蛋白重链的可变区。 可变区具有75kDa的带。 用于癌细胞靶向的药物组合物含有低分子结合诱导肽。
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