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公开(公告)号：KR1020090116653A
公开(公告)日：2009-11-11
申请号：KR1020090039472
申请日：2009-05-06
Applicant: 재단법인서울대학교산학협력재단
CPC classification number: G01N21/658 , B82Y30/00 , G01N33/54346 , Y10T428/2991
Abstract: PURPOSE: An Au/Ag core-shell composite for use as bio-sensors is provided to allow Au particles to be stably coupled with organic molecules and to exhibit high optical characteristic of Ag particles and high stability in conditions of high salt density, high temperature, and long-term preservation. CONSTITUTION: An Au/Ag core-shell composite for use as bio-sensors is comprised of Au particles, Ag particles which surrounds the Au particles, and receptor including a target material recognition site which reacts to the target material. One end of the receptor is coupled with Au particles, some parts are inserted into an Ag particle layer, and the target material recognition site is exposed to the Ag particle layer. The receptor includes a spacer portion whose end is coupled with the surface of the Au particles and the other end is coupled with the target material recognition site.
Abstract translation: 目的：提供用作生物传感器的Au / Ag核 - 壳复合材料，以使Au颗粒与有机分子稳定耦合，并显示出Ag颗粒的高光学特性和高盐密度，高温条件下的高稳定性 ，并长期保存。 构成：用作生物传感器的Au / Ag核 - 壳复合材料包括Au颗粒，围绕Au颗粒的Ag颗粒和包含与靶材料反应的靶材料识别位点的受体。 受体的一端与Au颗粒结合，一些部分被插入到Ag颗粒层中，并且靶材料识别位点暴露于Ag颗粒层。 受体包括间隔部分，其末端与Au颗粒的表面结合，另一端与目标材料识别位点结合。
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公开(公告)号：KR1020080093691A
公开(公告)日：2008-10-22
申请号：KR1020070037767
申请日：2007-04-18
Applicant: 재단법인서울대학교산학협력재단
IPC: C12Q1/00
CPC classification number: G01N33/5008 , C12N5/0068 , C12N2533/12 , C12N2535/00 , G01N33/54306
Abstract: A cell-assay method is provided to form various nano-structured matrices for cell culturing similar to in vivo environment easily and analyze influence of various structured three-dimensional surface and functional materials on cells on a chip. A cell-assay method comprises the steps of: (a) arraying nano-particles using a piezo-microarrayer on a glass slide; (b) arraying a functional material using the piezo-microarrayer on a nano-array obtained from the step(a) to modify the nano-particles; and (c) culturing cells on the surface of the nano-array modified by the functional material and analyzing them, wherein the nano-particle is at least one selected from the group consisting of gold nanosphere, gold nanotriangle, gold nanocube, gold nanotetrapod, gold nanohexagon, silver nanosphere, silver nanotriangle and a mixture thereof and the functional material is at least one selected from the group consisting of extracellular matrix(ECM) proteins, medicines for treatment, medicines for diagnosis, and growth factors. Additionally, a step of surface -treating a glass slide with a coating agent selected from silane-polyethyleneglycol and poly(L-lysine)-g-polyethyleneglycol before the step (a) is comprised in the cell-assay method.
Abstract translation: 提供细胞测定方法，容易地形成用于细胞培养的各种纳米结构基质，并分析各种结构的三维表面和功能材料对芯片上的细胞的影响。 细胞分析方法包括以下步骤：（a）使用压电微阵列器在载玻片上排列纳米颗粒; （b）使用压电微阵列器在由步骤（a）获得的纳米阵列上排列功能材料以修饰纳米颗粒; 和（c）在由功能材料修饰的纳米阵列的表面上培养细胞并对其进行分析，其中纳米颗粒是选自金纳米球，金纳米三角，金纳米管，金纳米四面体， 金纳米六角珠，银纳米球，银纳米三角及其混合物，功能材料为选自细胞外基质（ECM）蛋白，治疗药物，诊断用药物和生长因子中的至少一种。 此外，在步骤（a）之前，用选自硅烷 - 聚乙二醇和聚（L-赖氨酸）-g-聚乙二醇的涂层剂在玻璃载片上表面起作用的步骤包括在细胞测定方法中。
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公开(公告)号：KR101153748B1
公开(公告)日：2012-06-14
申请号：KR1020090039472
申请日：2009-05-06
Applicant: 재단법인서울대학교산학협력재단
CPC classification number: G01N21/658 , B82Y30/00 , G01N33/54346 , Y10T428/2991
Abstract: 본 발명은 금 나노입자; 상기 금 나노입자를 둘러싸며 형성된 은 나노입자층; 및 표적물질과 결합 또는 반응할 수 있는 표적물질 인지부위를 포함하는 리셉터를 포함하며, 상기 리셉터는 그 한쪽 말단이 상기 금 나노입자 표면에 결합되어 일부는 상기 은 나노입자층에 삽입되고, 상기 표적물질 인지부위는 상기 은 나노입자층 외부로 노출된 금/은 코어쉘 복합체, 그의 제조방법 및 이를 이용하는 바이오센서에 관한 것이다. 본 발명에 따른 금/은 코어쉘 복합체는 금 나노입자의 바이오 분자와의 안정적인 결합 및 은 나노입자의 우수한 광학적 특성을 모두 발휘할 수 있다. 따라서, 상기 복합체를 이용한 바이오센서는 표적 물질을 효율적으로 검출할 수 있어 의학 및 약학 등의 다양한 분야에 광범위하게 적용될 수 있다.
금/은 코어쉘, 복합체, 바이오센서, 리셉터, 표적물질, 올리고뉴클레오티드, 항체
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