公开(公告)号：KR100881407B1

公开(公告)日：2009-02-05

申请号：KR1020070091886

申请日：2007-09-11

Applicant: 재단법인서울대학교산학협력재단

Inventor： 이윤우 ,  주준호 ,  리광화 ,  노경호

IPC: C07C233/07 ,  C07C233/01

CPC classification number: Y02P20/544

Abstract: Acetaminophen fine particles are provided to control the crystal polymorphism of drug by diversifying parameters in manufacturing the particles and to be usable for an immediate release analgesic composition due to improved elution rate. A method for manufacturing acetaminophen fine particles comprises (a) a step for preparing the solution by dissolving acetaminophen in ethylacetate or tetrahydrofurane; (b) a step for preparing the acetaminophen fine particles by mixing carbon dioxide of 0-45 °C and 35-200 pressure(atm) and the solution obtained from the (a) step in a precipitator; (c) a step for removing an organic solvent remaining in particles by using the supercritical carbon dioxide of 0-45 °C and 35-200 pressure(atm); and (d) a step for collecting the fine particles generated through the pressure reduction of the inside of the precipitator.

Abstract translation: 提供对乙酰氨基酚微粒以通过使制造颗粒的参数多样化来控制药物的晶体多晶性，并且由于洗脱速率的提高，可用于立即释放止痛组合物。 制备对乙酰氨基酚微粒的方法包括（a）通过将对乙酰氨基酚溶解在乙酸乙酯或四氢呋喃中制备溶液的步骤; （b）通过混合0-45℃和35-200压力（atm）的二氧化碳和从（a）步骤获得的溶液在沉淀器中制备对乙酰氨基酚微粒的步骤; （c）通过使用0-45℃和35-200压力（atm）的超临界二氧化碳除去残留在颗粒中的有机溶剂的步骤; 和（d）用于收集通过除尘器内部的减压产生的微粒子的步骤。