公开(公告)号：KR100874125B1

公开(公告)日：2008-12-15

申请号：KR1020070068895

申请日：2007-07-09

Applicant: 재단법인서울대학교산학협력재단

Inventor： 이윤우 ,  김화용 ,  주준호 ,  신내철

IPC: C07D501/34 ,  C07D501/36 ,  C07D501/12

CPC classification number: Y02P20/544 ,  C07D501/12 ,  C07D501/34

Abstract: A method for preparing cefpodoxime proxetil is provided to remove a remaining solvent nearly or completely by carrying out the drying process by using supercritical and subcritical carbon dioxide. A method for preparing cefpodoxime proxetil comprises the step of drying it by using the supercritical and subcritical carbon dioxide at a temperature of 0-70 deg.C and at a pressure of 35-600 atm. to remove the remaining organic solvent.

Abstract translation: 提供制备头孢泊肟酯的方法，通过使用超临界和亚临界二氧化碳进行干燥过程，几乎或完全地除去残留的溶剂。 制备头孢泊肟原料的方法包括使用超临界和亚临界二氧化碳在0-70℃和35-600atm压力下干燥方法。 以除去剩余的有机溶剂。

公开(公告)号：KR100881407B1

公开(公告)日：2009-02-05

申请号：KR1020070091886

申请日：2007-09-11

Applicant: 재단법인서울대학교산학협력재단

Inventor： 이윤우 ,  주준호 ,  리광화 ,  노경호

IPC: C07C233/07 ,  C07C233/01

CPC classification number: Y02P20/544

Abstract: Acetaminophen fine particles are provided to control the crystal polymorphism of drug by diversifying parameters in manufacturing the particles and to be usable for an immediate release analgesic composition due to improved elution rate. A method for manufacturing acetaminophen fine particles comprises (a) a step for preparing the solution by dissolving acetaminophen in ethylacetate or tetrahydrofurane; (b) a step for preparing the acetaminophen fine particles by mixing carbon dioxide of 0-45 °C and 35-200 pressure(atm) and the solution obtained from the (a) step in a precipitator; (c) a step for removing an organic solvent remaining in particles by using the supercritical carbon dioxide of 0-45 °C and 35-200 pressure(atm); and (d) a step for collecting the fine particles generated through the pressure reduction of the inside of the precipitator.

Abstract translation: 提供对乙酰氨基酚微粒以通过使制造颗粒的参数多样化来控制药物的晶体多晶性，并且由于洗脱速率的提高，可用于立即释放止痛组合物。 制备对乙酰氨基酚微粒的方法包括（a）通过将对乙酰氨基酚溶解在乙酸乙酯或四氢呋喃中制备溶液的步骤; （b）通过混合0-45℃和35-200压力（atm）的二氧化碳和从（a）步骤获得的溶液在沉淀器中制备对乙酰氨基酚微粒的步骤; （c）通过使用0-45℃和35-200压力（atm）的超临界二氧化碳除去残留在颗粒中的有机溶剂的步骤; 和（d）用于收集通过除尘器内部的减压产生的微粒子的步骤。

公开(公告)号：KR100840132B1

公开(公告)日：2008-06-23

申请号：KR1020070037619

申请日：2007-04-17

Applicant: 재단법인서울대학교산학협력재단

Inventor： 주준호 ,  신내철 ,  김화용 ,  이윤우

IPC: C07D501/59 ,  B01D11/00

Abstract: A method for drying cefpodoxime proxetil is provided to obtain the cefpodoxime proxetil with almost no remaining solvent with reduced cost and drying time by performing a drying process using a saturated liquid CO2, which is relatively cheap, harmless to human body and non-reactive with a product. A method for drying cefpodoxime proxetil comprises a step of removing at least one remaining organic solvent selected from the group consisting of diisopropylether, ethyl acetate and dichloromethane by circulating saturated liquid carbon dioxide using a reboiler and a condenser without using a power unit such as a pump during a process of preparing the cefpodoxime proxetil.

Abstract translation: 提供了一种干燥头孢泊肟原料的方法，通过使用相对便宜的对人体无害的并且与人体无反应的饱和液体CO 2进行干燥处理，几乎没有残留的溶剂，几乎没有残留的溶剂，从而获得头孢泊肟几乎没有残留的溶剂 产品。 用于干燥头孢泊肟原料的方法包括通过使用再沸器和冷凝器循环饱和液体二氧化碳除去至少一种选自二异丙醚，乙酸乙酯和二氯甲烷的剩余有机溶剂的步骤，而不使用动力单元如泵 在制备头孢泊肟原料的过程中。